136134 20250325111549.0 10.1002/mds.23318 doi pmid:20623690 pmid pmc:PMC2989455 pmc 0885-3185 ISSN 1531-8257 ISSN altmetric:542759 altmetric DZNE-2020-02456 English 610 Minnerop, Martina P:(DE-HGF)0 0 Corresponding author Callosal tissue loss in multiple system atrophy--a one-year follow-up study. New York, NY 2010 Wiley online Crossref Wiley 2010-07-08 print Crossref Wiley 2010-11-15 article DRIVER Output Types/Journal article DataCite Journal Article journal journal PUB:(DE-HGF)16 1742897712_24043 PUB:(DE-HGF) ARTICLE BibTeX JOURNAL_ARTICLE ORCID Journal Article 0 EndNote Multiple system atrophy (MSA) is a neurodegenerative disease not only affecting the basal ganglia, brainstem, cerebellum, and intermediolateral cell columns of the spinal cord but also the cerebral cortex. Clinically, cerebellar (MSA-C) and parkinsonian variants of MSA (MSA-P) are distinguished. We investigated 14 MSA patients (10 MSA-C, 4 MSA-P, men: 7, women: 7; age: 61.1 ± 3.3 years) and 14 matched controls (men: 7, women: 7; age: 58.6 ± 5.1 years) with voxel-based morphometry (VBM) to analyze gray and white matter differences both at baseline and at follow-up, 1 year later. Baseline comparisons between patients and controls confirmed significantly less gray matter in MSA in the cerebellum and cerebral cortex, and significantly less white matter in the cerebellar peduncles and brainstem. Comparisons of tissue-loss profiles (i.e., baseline versus follow-up) between patients and controls, revealed white matter reduction in MSA along the middle cerebellar peduncles, reflecting degeneration of the ponto-cerebellar tract as a particularly prominent and progressive morphological alteration in MSA. Comparisons between baseline and follow-up, separately performed in patients and controls, revealed additional white matter reduction in MSA along the corpus callosum at follow-up. This was replicated through additional shape-based analyses indicating a reduced callosal thickness in the anterior and posterior midbody, extending posteriorly into the isthmus. Callosal atrophy may possibly reflect a disease-specific pattern of neurodegeneration and cortical atrophy, fitting well with the predominant impairment of motor functions in the MSA patients. 344 - Clinical and Health Care Research (POF3-344) G:(DE-HGF)POF3-344 POF3-344 POF III 0 2015-09-01 Crossref http://doi.wiley.com/10.1002/tdm_license_1.1 Dataset connected to CrossRef, PubMed, Aged MeSH Atrophy: pathology MeSH Brain Stem: pathology MeSH Cerebellum: pathology MeSH Corpus Callosum: pathology MeSH Female MeSH Follow-Up Studies MeSH Humans MeSH Image Processing, Computer-Assisted MeSH Magnetic Resonance Imaging MeSH Male MeSH Middle Aged MeSH Multiple System Atrophy: pathology MeSH Lüders, Eileen P:(DE-HGF)0 1 Specht, Karsten P:(DE-HGF)0 2 Ruhlmann, Jürgen P:(DE-HGF)0 3 Schimke, Nicole P:(DE-HGF)0 4 Thompson, Paul M P:(DE-HGF)0 5 Chou, Yi Y P:(DE-HGF)0 6 Toga, Arthur W P:(DE-HGF)0 7 Abele, Michael P:(DE-HGF)0 8 Wüllner, Ullrich P:(DE-HGF)0 9 Klockgether, Thomas P:(DE-2719)2810314 10 Last author 10.1002/mds.23318 : Wiley, 2010-07-08 15 2613-2620 journal-article Crossref Movement Disorders 25 2010 0885-3185 10.1002/mds.23318 Vol. 25, no. 15, p. 2613 - 2620 PERI:(DE-600)2041249-6 15 25:15<2613 - 2620 2613-2620 Movement disorders 25 2010 0885-3185 Pubmed Central http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2989455 http://pub.dzne.de/record/136134/files/DZNE-2020-02456_Restricted.pdf http://pub.dzne.de/record/136134/files/DZNE-2020-02456_Restricted.pdf?subformat=pdfa pdfa VDB oai:pub.dzne.de:136134 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 10 P:(DE-2719)2810314 DE-HGF Gesundheit Erkrankungen des Nervensystems G:(DE-HGF)POF3-340 G:(DE-HGF)POF3-344 G:(DE-HGF)POF3 G:(DE-HGF)POF3-300 G:(DE-HGF)POF Clinical and Health Care Research 0 2010 Nationallizenz StatID:(DE-HGF)0420 StatID JCR StatID:(DE-HGF)0100 StatID MOVEMENT DISORD : 2017 DBCoverage StatID:(DE-HGF)0200 StatID SCOPUS DBCoverage StatID:(DE-HGF)0300 StatID Medline DBCoverage StatID:(DE-HGF)0310 StatID NCBI Molecular Biology Database DBCoverage StatID:(DE-HGF)0199 StatID Clarivate Analytics Master Journal List WoS StatID:(DE-HGF)0110 StatID Science Citation Index DBCoverage StatID:(DE-HGF)0150 StatID Web of Science Core Collection WoS StatID:(DE-HGF)0111 StatID Science Citation Index Expanded DBCoverage StatID:(DE-HGF)1110 StatID Current Contents - 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