136185 20250411151432.0 10.4161/auto.7.3.14348 doi pmid:21187721 pmid 1554-8627 ISSN 1554-8635 ISSN altmetric:3466127 altmetric DZNE-2020-02507 English 570 Springer, Wolfdieter P:(DE-2719)2380511 0 First author dzne Regulation of PINK1-Parkin-mediated mitophagy. Abingdon, Oxon 2011 Taylor & Francis online Crossref Informa UK Limited 2014-10-27 print Crossref Informa UK Limited 2011-03-01 article DRIVER Output Types/Journal article DataCite Journal Article journal journal PUB:(DE-HGF)16 1744377232_23681 PUB:(DE-HGF) Review Article ARTICLE BibTeX JOURNAL_ARTICLE ORCID Journal Article 0 EndNote Parkinson disease (PD) is a devastating disorder of the nervous system for which no cure exists. Although the exact mechanisms involved in the pathogenesis of PD are unclear, very recently, a novel cellular process has been identified that promises great future potential. Two PD-associated genes have been found to converge on the emerging mitophagy pathway that links the two major cellular dysfunctions implicated in the pathogenesis of PD. Thereby, PINK1 and Parkin physically associate and functionally cooperate to identify and label damaged mitochondria for selective degradation via autophagy. PD-associated mutations in both genes disrupt mitophagy although through different mechanisms, revealing a sequential multistep process. Further key players that tie into this process have been identified and provide the framework for future research aiming at a complete dissection of this neuroprotective pathway. This may not only yield novel targets for therapeutic intervention in PD, but possibly for other neurodegenerative disorders as well. 345 - Population Studies and Genetics (POF3-345) G:(DE-HGF)POF3-345 POF3-345 POF III 0 Dataset connected to CrossRef, PubMed, Ubiquitin-Protein Ligases EC 2.3.2.27 NLM Chemicals parkin protein EC 2.3.2.27 NLM Chemicals Protein Kinases EC 2.7.- NLM Chemicals PTEN-induced putative kinase EC 2.7.11.1 NLM Chemicals Animals MeSH Autophagy MeSH Humans MeSH Mitochondria: enzymology MeSH Parkinson Disease: enzymology MeSH Parkinson Disease: pathology MeSH Protein Kinases: metabolism MeSH Proteolysis MeSH Ubiquitin-Protein Ligases: metabolism MeSH Kahle, Philipp J P:(DE-2719)2810803 1 Last author dzne 10.4161/auto.7.3.14348 : Informa UK Limited, 2011-03-01 3 266-278 journal-article Crossref Autophagy 7 2011 1554-8627 10.4161/auto.7.3.14348 Vol. 7, no. 3, p. 266 - 278 PERI:(DE-600)2262043-6 3 7:3<266 - 278 266-278 Autophagy 7 2011 1554-8627 http://pub.dzne.de/record/136185/files/DZNE-2020-02507_Restricted.pdf http://pub.dzne.de/record/136185/files/DZNE-2020-02507_Restricted.pdf?subformat=pdfa pdfa VDB oai:pub.dzne.de:136185 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 0 P:(DE-2719)2380511 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 1 P:(DE-2719)2810803 DE-HGF Gesundheit Erkrankungen des Nervensystems G:(DE-HGF)POF3-340 G:(DE-HGF)POF3-345 G:(DE-HGF)POF3 G:(DE-HGF)POF3-300 G:(DE-HGF)POF Population Studies and Genetics 0 2011 DBCoverage StatID:(DE-HGF)0300 StatID Medline DBCoverage StatID:(DE-HGF)0310 StatID NCBI Molecular Biology Database DBCoverage StatID:(DE-HGF)0320 StatID PubMed Central JCR StatID:(DE-HGF)0100 StatID AUTOPHAGY : 2017 DBCoverage StatID:(DE-HGF)0200 StatID SCOPUS DBCoverage StatID:(DE-HGF)0199 StatID Clarivate Analytics Master Journal List WoS StatID:(DE-HGF)0111 StatID Science Citation Index Expanded DBCoverage StatID:(DE-HGF)0150 StatID Web of Science Core Collection DBCoverage StatID:(DE-HGF)1050 StatID BIOSIS Previews IF >= 10 StatID:(DE-HGF)9910 StatID AUTOPHAGY : 2017 I:(DE-2719)1210000-4 AG Kahle Functional Neurogenetics 0 journal VDB I:(DE-2719)1210000-4 UNRESTRICTED