TY  - JOUR
AU  - Förster, Stefan
AU  - Buschert, Verena C
AU  - Teipel, Stefan
AU  - Friese, Uwe
AU  - Buchholz, Hans-Georg
AU  - Drzezga, Alexander
AU  - Hampel, Harald
AU  - Bartenstein, Peter
AU  - Buerger, Katharina
TI  - Effects of a 6-month cognitive intervention on brain metabolism in patients with amnestic MCI and mild Alzheimer's disease.
JO  - Journal of Alzheimer's disease
VL  - 26
IS  - s3
SN  - 1875-8908
CY  - Amsterdam
PB  - IOS Press
M1  - DZNE-2020-02689
SP  - 337-348
PY  - 2011
AB  - The effect of cognitive intervention on brain metabolism in AD is largely unexplored. Therefore, we aimed to investigate cognitive parameters and 18FDG PET to test for effects of a cognitive intervention in patients with aMCI or mild AD. Patients with aMCI (N = 24) or mild AD (N = 15) were randomly assigned either to cognitive intervention groups (IGs), receiving weekly sessions of group-based multicomponent cognitive intervention, or active control groups (CGs), receiving pencil-paper exercises for self-study. We obtained resting-state FDG-PET scans and neuropsychological testing at baseline and after six-months. Normalized FDG-PET images were analyzed using voxel-based SPM5 approaches to determine longitudinal changes, group-by-time interactions and correlations with neuropsychological outcome parameters. Primary global cognitive outcome was determined by analyses of covariance with MMSE and ADAS-cog scores as dependent measures. Both, aMCI and AD subgroups of CGs showed widespread bilateral cortical declines in FDG uptake, while the AD subgroup of IGs showed discrete decline or rather no decline in case of the aMCI subgroup. Group by time analyses revealed strongest attenuation of metabolic decline in the aMCI subgroup of the IGs, involving left anterior temporal pole and anterior cingulate gyrus. However, correlation analyses revealed only weak non-significant associations between increased FDG uptake and improvement in primary or secondary outcome parameters. Concurrently, there was significant improvement in global cognitive status in the aMCI subgroup of the IGs. A six-month cognitive intervention imparted cognitive benefits in patients with aMCI, which were concurrent with an attenuated decline of glucose metabolism in cortical regions affected by neurodegenerative AD.
KW  - Aged
KW  - Aged, 80 and over
KW  - Alzheimer Disease: diagnostic imaging
KW  - Alzheimer Disease: pathology
KW  - Alzheimer Disease: rehabilitation
KW  - Amnesia: complications
KW  - Brain Mapping
KW  - Cerebral Cortex: diagnostic imaging
KW  - Cerebral Cortex: metabolism
KW  - Cognitive Behavioral Therapy: methods
KW  - Cognitive Dysfunction: diagnostic imaging
KW  - Cognitive Dysfunction: etiology
KW  - Cognitive Dysfunction: pathology
KW  - Cognitive Dysfunction: rehabilitation
KW  - Female
KW  - Fluorodeoxyglucose F18
KW  - Follow-Up Studies
KW  - Humans
KW  - Male
KW  - Middle Aged
KW  - Neuropsychological Tests
KW  - Positron-Emission Tomography: methods
KW  - Treatment Outcome
KW  - Fluorodeoxyglucose F18 (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:21971473
DO  - DOI:10.3233/JAD-2011-0025
UR  - https://pub.dzne.de/record/136367
ER  -