engLatz, EickeXiao, T SamStutz, AndreaActivation and regulation of the inflammasomes.info:eu-repo/classification/ddc/570Autophagy: immunologyCarrier Proteins: immunologyCarrier Proteins: metabolismHumansInflammasomes: immunologyInflammasomes: metabolismInflammation Mediators: immunologyInflammation Mediators: metabolismInterleukin-18: immunologyInterleukin-18: metabolismInterleukin-1beta: immunologyInterleukin-1beta: metabolismModels, ImmunologicalNLR Family, Pyrin Domain-Containing 3 ProteinReceptors, Interleukin-1: immunologyReceptors, Interleukin-1: metabolismSignal Transduction: immunologyCarrier ProteinsInflammasomesInflammation MediatorsInterleukin-18Interleukin-1betaNLR Family, Pyrin Domain-Containing 3 ProteinNLRP3 protein, humanReceptors, Interleukin-1Inflammasomes are key signalling platforms that detect pathogenic microorganisms and sterile stressors, and that activate the highly pro-inflammatory cytokines interleukin-1β (IL-1β) and IL-18. In this Review, we discuss the complex regulatory mechanisms that facilitate a balanced but effective inflammasome-mediated immune response, and we highlight the similarities to another molecular signalling platform - the apoptosome - that monitors cellular health. Extracellular regulatory mechanisms are discussed, as well as the intracellular control of inflammasome assembly, for example, via ion fluxes, free radicals and autophagy.Nature reviews / Immunology 13(6), 397-411 (2013). doi:10.1038/nri3452info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionNature Publ. Group2013info:eu-repo/semantics/closedAccessDEhttps://pub.dzne.de/record/136923https://pub.dzne.de/search?p=id:%22DZNE-2020-03245%22Researchersinfo:eu-repo/semantics/altIdentifier/issn/1474-1741info:eu-repo/semantics/altIdentifier/doi/10.1038/nri3452info:eu-repo/semantics/altIdentifier/issn/1474-1733info:eu-repo/semantics/altIdentifier/pmid/pmid:23702978