17 Latz, Eicke Xiao, T Sam Stutz, Andrea AG Latz Nature reviews / Immunology Nature reviews / Immunology Nature Publ. Group London 1474-1733 10.1038/nri3452 English 397-411 6 13 Inflammasomes are key signalling platforms that detect pathogenic microorganisms and sterile stressors, and that activate the highly pro-inflammatory cytokines interleukin-1β (IL-1β) and IL-18. In this Review, we discuss the complex regulatory mechanisms that facilitate a balanced but effective inflammasome-mediated immune response, and we highlight the similarities to another molecular signalling platform - the apoptosome - that monitors cellular health. Extracellular regulatory mechanisms are discussed, as well as the intracellular control of inflammasome assembly, for example, via ion fluxes, free radicals and autophagy. PUB:(DE-HGF)16, Review Article; 0, ; Autophagy: immunology Carrier Proteins: immunology Carrier Proteins: metabolism Humans Inflammasomes: immunology Inflammasomes: metabolism Inflammation Mediators: immunology Inflammation Mediators: metabolism Interleukin-18: immunology Interleukin-18: metabolism Interleukin-1beta: immunology Interleukin-1beta: metabolism Models, Immunological NLR Family, Pyrin Domain-Containing 3 Protein Receptors, Interleukin-1: immunology Receptors, Interleukin-1: metabolism Signal Transduction: immunology Carrier Proteins Inflammasomes Inflammation Mediators Interleukin-18 Interleukin-1beta NLR Family, Pyrin Domain-Containing 3 Protein NLRP3 protein, human Receptors, Interleukin-1 Journal Article (Review Article) 2013 DZNE-2020-03245 2013 pmc:PMC3807999 pmid:23702978 https://pub.dzne.de/record/136923 https://doi.org/10.1038/nri3452