136923 20250318152217.0 10.1038/nri3452 doi pmid:23702978 pmid pmc:PMC3807999 pmc 1474-1733 ISSN 1474-1741 ISSN altmetric:1505112 altmetric DZNE-2020-03245 English 570 Latz, Eicke P:(DE-2719)2000062 0 First author dzne Activation and regulation of the inflammasomes. London 2013 Nature Publ. Group online Crossref Springer Science and Business Media LLC 2013-05-24 print Crossref Springer Science and Business Media LLC 2013-06-01 article DRIVER Output Types/Journal article DataCite Journal Article journal journal PUB:(DE-HGF)16 1742307682_17414 PUB:(DE-HGF) Review Article ARTICLE BibTeX JOURNAL_ARTICLE ORCID Journal Article 0 EndNote Inflammasomes are key signalling platforms that detect pathogenic microorganisms and sterile stressors, and that activate the highly pro-inflammatory cytokines interleukin-1β (IL-1β) and IL-18. In this Review, we discuss the complex regulatory mechanisms that facilitate a balanced but effective inflammasome-mediated immune response, and we highlight the similarities to another molecular signalling platform - the apoptosome - that monitors cellular health. Extracellular regulatory mechanisms are discussed, as well as the intracellular control of inflammasome assembly, for example, via ion fluxes, free radicals and autophagy. 342 - Disease Mechanisms and Model Systems (POF3-342) G:(DE-HGF)POF3-342 POF3-342 POF III 0 2013-05-24 Crossref http://www.springer.com/tdm Dataset connected to CrossRef, PubMed, Carrier Proteins NLM Chemicals Inflammasomes NLM Chemicals Inflammation Mediators NLM Chemicals Interleukin-18 NLM Chemicals Interleukin-1beta NLM Chemicals NLR Family, Pyrin Domain-Containing 3 Protein NLM Chemicals NLRP3 protein, human NLM Chemicals Receptors, Interleukin-1 NLM Chemicals Autophagy: immunology MeSH Carrier Proteins: immunology MeSH Carrier Proteins: metabolism MeSH Humans MeSH Inflammasomes: immunology MeSH Inflammasomes: metabolism MeSH Inflammation Mediators: immunology MeSH Inflammation Mediators: metabolism MeSH Interleukin-18: immunology MeSH Interleukin-18: metabolism MeSH Interleukin-1beta: immunology MeSH Interleukin-1beta: metabolism MeSH Models, Immunological MeSH NLR Family, Pyrin Domain-Containing 3 Protein MeSH Receptors, Interleukin-1: immunology MeSH Receptors, Interleukin-1: metabolism MeSH Signal Transduction: immunology MeSH Xiao, T Sam P:(DE-HGF)0 1 Stutz, Andrea P:(DE-HGF)0 2 10.1038/nri3452 : Springer Science and Business Media LLC, 2013-05-24 6 397-411 journal-article Crossref Nature Reviews Immunology 13 2013 1474-1733 10.1038/nri3452 Vol. 13, no. 6, p. 397 - 411 PERI:(DE-600)2060551-1 6 13:6<397 - 411 397-411 Nature reviews / Immunology 13 2013 1474-1733 Pubmed Central http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3807999 http://pub.dzne.de/record/136923/files/DZNE-2020-03245_Restricted.pdf http://pub.dzne.de/record/136923/files/DZNE-2020-03245_Restricted.pdf?subformat=pdfa pdfa dnbdelivery VDB oai:pub.dzne.de:136923 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 0 P:(DE-2719)2000062 DE-HGF Gesundheit Erkrankungen des Nervensystems G:(DE-HGF)POF3-340 G:(DE-HGF)POF3-342 G:(DE-HGF)POF3 G:(DE-HGF)POF3-300 G:(DE-HGF)POF Disease Mechanisms and Model Systems 0 2013 DBCoverage StatID:(DE-HGF)0200 StatID SCOPUS IF >= 40 StatID:(DE-HGF)9940 StatID NAT REV IMMUNOL : 2017 DBCoverage StatID:(DE-HGF)1030 StatID Current Contents - Life Sciences DBCoverage StatID:(DE-HGF)0600 StatID Ebsco Academic Search JCR StatID:(DE-HGF)0100 StatID NAT REV IMMUNOL : 2017 DBCoverage StatID:(DE-HGF)0150 StatID Web of Science Core Collection WoS StatID:(DE-HGF)0110 StatID Science Citation Index WoS StatID:(DE-HGF)0111 StatID Science Citation Index Expanded DBCoverage StatID:(DE-HGF)1120 StatID BIOSIS Reviews Reports And Meetings Peer Review StatID:(DE-HGF)0030 StatID ASC DBCoverage StatID:(DE-HGF)0310 StatID NCBI Molecular Biology Database DBCoverage StatID:(DE-HGF)1050 StatID BIOSIS Previews DBCoverage StatID:(DE-HGF)0300 StatID Medline DBCoverage StatID:(DE-HGF)1110 StatID Current Contents - Clinical Medicine Nationallizenz StatID:(DE-HGF)0420 StatID DBCoverage StatID:(DE-HGF)0199 StatID Clarivate Analytics Master Journal List I:(DE-2719)1013024 AG Latz Innate Immunity in Neurodegeneration 0 journal VDB I:(DE-2719)1013024 UNRESTRICTED -- missing cx lookup -- 10.1016/j.immuni.2011.05.006 Crossref 10.1016/j.immuni.2011.05.006 -- missing cx lookup -- 10.1111/j.1600-065X.2011.01052.x Crossref 10.1111/j.1600-065X.2011.01052.x -- missing cx lookup -- 10.1016/S1097-2765(02)00599-3 Crossref 10.1016/S1097-2765(02)00599-3 -- missing cx lookup -- 10.1111/j.1600-065X.2011.01044.x Crossref 10.1111/j.1600-065X.2011.01044.x -- missing cx lookup -- 10.1074/jbc.M112.381228 Crossref 10.1074/jbc.M112.381228 -- missing cx lookup -- 10.1038/sj.cdd.4402194 Crossref 10.1038/sj.cdd.4402194 -- missing cx lookup -- 10.1042/BJ20121198 Crossref 10.1042/BJ20121198 -- missing cx lookup -- 10.1074/jbc.M708182200 Crossref 10.1074/jbc.M708182200 -- missing cx lookup -- 10.1038/356768a0 Crossref 10.1038/356768a0 -- missing cx lookup -- 10.1126/science.275.5297.206 Crossref 10.1126/science.275.5297.206 -- missing cx lookup -- 10.1146/annurev.immunol.021908.132612 Crossref 10.1146/annurev.immunol.021908.132612 -- missing cx lookup -- 10.1016/j.immuni.2008.02.005 Crossref 10.1016/j.immuni.2008.02.005 -- missing cx lookup -- 10.1016/j.molcel.2007.01.032 Crossref 10.1016/j.molcel.2007.01.032 -- missing cx lookup -- 10.1038/nature02664 Crossref 10.1038/nature02664 -- missing cx lookup -- 10.1038/ni1344 Crossref 10.1038/ni1344 -- missing cx lookup -- 10.1038/ni1346 Crossref 10.1038/ni1346 -- missing cx lookup -- 10.1006/bbrc.2001.4928 Crossref 10.1006/bbrc.2001.4928 -- missing cx lookup -- 10.1038/nri2690 Crossref 10.1038/nri2690 -- missing cx lookup -- 10.1038/ni.1824 Crossref 10.1038/ni.1824 -- missing cx lookup -- 10.4049/jimmunol.1002227 Crossref 10.4049/jimmunol.1002227 -- missing cx lookup -- 10.1016/j.immuni.2012.03.012 Crossref 10.1016/j.immuni.2012.03.012 -- missing cx lookup -- 10.1038/nature11250 Crossref 10.1038/nature11250 -- missing cx lookup -- 10.1038/ni.1932 Crossref 10.1038/ni.1932 -- missing cx lookup -- 10.1111/j.1600-065X.2011.01050.x Crossref 10.1111/j.1600-065X.2011.01050.x -- missing cx lookup -- 10.1016/j.chom.2011.04.008 Crossref 10.1016/j.chom.2011.04.008 -- missing cx lookup -- 10.1016/j.biocel.2010.01.003 Crossref 10.1016/j.biocel.2010.01.003 -- missing cx lookup -- 10.1038/ng1724 Crossref 10.1038/ng1724 -- missing cx lookup -- 10.1016/j.immuni.2012.02.001 Crossref 10.1016/j.immuni.2012.02.001 -- missing cx lookup -- 10.1016/j.cell.2011.04.022 Crossref 10.1016/j.cell.2011.04.022 -- missing cx lookup -- 10.4049/jimmunol.1100412 Crossref 10.4049/jimmunol.1100412 -- missing cx lookup -- 10.1016/j.immuni.2012.07.006 Crossref 10.1016/j.immuni.2012.07.006 -- missing cx lookup -- 10.1073/pnas.0802726105 Crossref 10.1073/pnas.0802726105 -- missing cx lookup -- 10.1002/eji.200737103 Crossref 10.1002/eji.200737103 -- missing cx lookup -- 10.1038/nature10394 Crossref 10.1038/nature10394 -- missing cx lookup -- 10.1038/nature10510 Crossref 10.1038/nature10510 -- missing cx lookup -- 10.4049/jimmunol.180.10.6808 Crossref 10.4049/jimmunol.180.10.6808 -- missing cx lookup -- 10.4049/jimmunol.0901363 Crossref 10.4049/jimmunol.0901363 -- missing cx lookup -- 10.4049/jimmunol.0900173 Crossref 10.4049/jimmunol.0900173 -- missing cx lookup -- 10.1126/science.1217141 Crossref 10.1126/science.1217141 -- missing cx lookup -- 10.1016/j.immuni.2012.01.009 Crossref 10.1016/j.immuni.2012.01.009 -- missing cx lookup -- 10.1038/nature10558 Crossref 10.1038/nature10558 -- missing cx lookup -- 10.1016/j.cell.2012.07.007 Crossref 10.1016/j.cell.2012.07.007 -- missing cx lookup -- 10.1074/jbc.M112.401406 Crossref 10.1074/jbc.M112.401406 -- missing cx lookup -- 10.1038/nature10072 Crossref 10.1038/nature10072 -- missing cx lookup -- 10.1016/j.immuni.2012.05.001 Crossref 10.1016/j.immuni.2012.05.001 -- missing cx lookup -- 10.1038/nature11419 Crossref 10.1038/nature11419 -- missing cx lookup -- 10.1126/science.1230751 Crossref 10.1126/science.1230751 -- missing cx lookup -- 10.1371/journal.ppat.1003144 Crossref 10.1371/journal.ppat.1003144 -- missing cx lookup -- 10.4049/jimmunol.0904189 Crossref 10.4049/jimmunol.0904189 -- missing cx lookup -- 10.4049/jimmunol.1004062 Crossref 10.4049/jimmunol.1004062 -- missing cx lookup -- 10.4049/jimmunol.1200136 Crossref 10.4049/jimmunol.1200136 -- missing cx lookup -- 10.1016/j.immuni.2012.01.018 Crossref 10.1016/j.immuni.2012.01.018 -- missing cx lookup -- 10.1038/ni.2222 Crossref 10.1038/ni.2222 -- missing cx lookup -- 10.1038/nature07965 Crossref 10.1038/nature07965 -- missing cx lookup -- 10.1084/jem.20071632 Crossref 10.1084/jem.20071632 -- missing cx lookup -- 10.1016/j.immuni.2012.01.012 Crossref 10.1016/j.immuni.2012.01.012 -- missing cx lookup -- 10.1016/j.immuni.2012.09.015 Crossref 10.1016/j.immuni.2012.09.015 -- missing cx lookup -- 10.1016/j.immuni.2011.10.016 Crossref 10.1016/j.immuni.2011.10.016 -- missing cx lookup -- 10.1038/3276 Crossref 10.1038/3276 -- missing cx lookup -- 10.4049/jimmunol.1202121 Crossref 10.4049/jimmunol.1202121 -- missing cx lookup -- 10.1093/intimm/dxq058 Crossref 10.1093/intimm/dxq058 -- missing cx lookup -- 10.1074/jbc.M112.407130 Crossref 10.1074/jbc.M112.407130 -- missing cx lookup -- 10.1016/j.molcel.2012.11.009 Crossref 10.1016/j.molcel.2012.11.009 -- missing cx lookup -- 10.1016/j.imbio.2012.07.020 Crossref 10.1016/j.imbio.2012.07.020 -- missing cx lookup -- 10.1038/ni.1702 Crossref 10.1038/ni.1702 -- missing cx lookup -- 10.1038/sj.onc.1201206 Crossref 10.1038/sj.onc.1201206 -- missing cx lookup -- 10.1038/nature11429 Crossref 10.1038/nature11429 -- missing cx lookup -- 10.1038/ni.1636 Crossref 10.1038/ni.1636 -- missing cx lookup -- 10.1038/gene.2008.66 Crossref 10.1038/gene.2008.66 -- missing cx lookup -- 10.1038/nature08100 Crossref 10.1038/nature08100 -- missing cx lookup -- 10.1038/ni.2474 Crossref 10.1038/ni.2474 -- missing cx lookup -- 10.1016/j.immuni.2011.02.006 Crossref 10.1016/j.immuni.2011.02.006 -- missing cx lookup -- 10.4049/jimmunol.1202479 Crossref 10.4049/jimmunol.1202479 -- missing cx lookup -- 10.4049/jimmunol.1200312 Crossref 10.4049/jimmunol.1200312 -- missing cx lookup -- 10.4049/jimmunol.1201516 Crossref 10.4049/jimmunol.1201516 -- missing cx lookup -- 10.1038/ni.1631 Crossref 10.1038/ni.1631 -- missing cx lookup -- 10.1074/jbc.M107419200 Crossref 10.1074/jbc.M107419200 -- missing cx lookup -- 10.1073/pnas.220416197 Crossref 10.1073/pnas.220416197 -- missing cx lookup -- 10.1038/sj.cdd.4402195 Crossref 10.1038/sj.cdd.4402195 -- missing cx lookup -- 10.1038/ni.1859 Crossref 10.1038/ni.1859 -- missing cx lookup -- 10.1074/jbc.M109.067298 Crossref 10.1074/jbc.M109.067298 -- missing cx lookup -- 10.1074/jbc.M610351200 Crossref 10.1074/jbc.M610351200 -- missing cx lookup -- 10.1038/sj.emboj.7601378 Crossref 10.1038/sj.emboj.7601378 -- missing cx lookup -- 10.1016/j.febslet.2005.12.004 Crossref 10.1016/j.febslet.2005.12.004 -- missing cx lookup -- 10.4049/jimmunol.1100478 Crossref 10.4049/jimmunol.1100478 -- missing cx lookup -- 10.1016/j.immuni.2012.06.013 Crossref 10.1016/j.immuni.2012.06.013 -- missing cx lookup -- 10.1038/cr.2010.135 Crossref 10.1038/cr.2010.135 -- missing cx lookup -- 10.1038/ncomms2608 Crossref 10.1038/ncomms2608 -- missing cx lookup -- 10.1073/pnas.1117765109 Crossref 10.1073/pnas.1117765109 -- missing cx lookup -- 10.1038/cddis.2011.132 Crossref 10.1038/cddis.2011.132 -- missing cx lookup -- 10.1038/nature11588 Crossref 10.1038/nature11588 -- missing cx lookup -- 10.1038/ncomms2339 Crossref 10.1038/ncomms2339 -- missing cx lookup -- 10.1038/cr.2009.19 Crossref 10.1038/cr.2009.19 -- missing cx lookup -- 10.1042/bj20021720 Crossref 10.1042/bj20021720 1998 Crossref YM Kim 1998 -- missing cx lookup -- 10.1074/jbc.M608083200 Crossref 10.1074/jbc.M608083200 -- missing cx lookup -- 10.1126/science.1156995 Crossref 10.1126/science.1156995 -- missing cx lookup -- 10.1073/pnas.0803933105 Crossref 10.1073/pnas.0803933105 -- missing cx lookup -- 10.1073/pnas.0914795107 Crossref 10.1073/pnas.0914795107 -- missing cx lookup -- 10.1182/blood-2010-01-264218 Crossref 10.1182/blood-2010-01-264218 -- missing cx lookup -- 10.1182/blood-2009-10-250803 Crossref 10.1182/blood-2009-10-250803 -- missing cx lookup -- 10.1038/nature09663 Crossref 10.1038/nature09663 -- missing cx lookup -- 10.4049/jimmunol.1100613 Crossref 10.4049/jimmunol.1100613 -- missing cx lookup -- 10.1007/s13238-011-1127-x Crossref 10.1007/s13238-011-1127-x -- missing cx lookup -- 10.1038/nature07383 Crossref 10.1038/nature07383 -- missing cx lookup -- 10.1038/ni.2215 Crossref 10.1038/ni.2215 -- missing cx lookup -- 10.1074/jbc.M110.202911 Crossref 10.1074/jbc.M110.202911 -- missing cx lookup -- 10.1016/S1074-7613(04)00046-9 Crossref 10.1016/S1074-7613(04)00046-9 -- missing cx lookup -- 10.1074/jbc.M100433200 Crossref 10.1074/jbc.M100433200 -- missing cx lookup -- 10.1038/nature04656 Crossref 10.1038/nature04656 -- missing cx lookup -- 10.1038/nature02451 Crossref 10.1038/nature02451 -- missing cx lookup -- 10.4049/jimmunol.179.12.7993 Crossref 10.4049/jimmunol.179.12.7993 -- missing cx lookup -- 10.1038/sj.cdd.4400881 Crossref 10.1038/sj.cdd.4400881 -- missing cx lookup -- 10.1074/jbc.M407891200 Crossref 10.1074/jbc.M407891200 -- missing cx lookup -- 10.1042/bj20030304 Crossref 10.1042/bj20030304 -- missing cx lookup -- 10.1128/IAI.01315-06 Crossref 10.1128/IAI.01315-06 -- missing cx lookup -- 10.4049/jimmunol.178.6.3837 Crossref 10.4049/jimmunol.178.6.3837 -- missing cx lookup -- 10.1186/1476-9255-7-23 Crossref 10.1186/1476-9255-7-23 -- missing cx lookup -- 10.4049/jimmunol.0900779 Crossref 10.4049/jimmunol.0900779 -- missing cx lookup -- 10.1093/intimm/dxh081 Crossref 10.1093/intimm/dxh081 -- missing cx lookup -- 10.1038/nature11012 Crossref 10.1038/nature11012 -- missing cx lookup -- 10.4049/jimmunol.1201715 Crossref 10.4049/jimmunol.1201715 -- missing cx lookup -- 10.1074/jbc.M410057200 Crossref 10.1074/jbc.M410057200 -- missing cx lookup -- 10.1371/journal.pone.0051105 Crossref 10.1371/journal.pone.0051105 -- missing cx lookup -- 10.1016/j.immuni.2011.02.020 Crossref 10.1016/j.immuni.2011.02.020 -- missing cx lookup -- 10.1371/journal.pone.0036044 Crossref 10.1371/journal.pone.0036044 -- missing cx lookup -- 10.1038/nature11290 Crossref 10.1038/nature11290 -- missing cx lookup -- 10.1002/eji.201243187 Crossref 10.1002/eji.201243187 -- missing cx lookup -- 10.1038/ni1459 Crossref 10.1038/ni1459 -- missing cx lookup -- 10.1016/j.immuni.2012.02.014 Crossref 10.1016/j.immuni.2012.02.014 -- missing cx lookup -- 10.1371/journal.pone.0027396 Crossref 10.1371/journal.pone.0027396 -- missing cx lookup -- 10.1371/journal.ppat.1002659 Crossref 10.1371/journal.ppat.1002659 -- missing cx lookup -- 10.1074/jbc.M112.378323 Crossref 10.1074/jbc.M112.378323 -- missing cx lookup -- 10.1074/jbc.M209369200 Crossref 10.1074/jbc.M209369200 -- missing cx lookup -- 10.1248/bpb.30.15 Crossref 10.1248/bpb.30.15 -- missing cx lookup -- 10.1371/journal.ppat.1002638 Crossref 10.1371/journal.ppat.1002638 -- missing cx lookup -- 10.1016/S1097-2765(02)00442-2 Crossref 10.1016/S1097-2765(02)00442-2 -- missing cx lookup -- 10.1016/j.gde.2010.12.001 Crossref 10.1016/j.gde.2010.12.001 -- missing cx lookup -- 10.1016/j.cell.2007.01.045 Crossref 10.1016/j.cell.2007.01.045 -- missing cx lookup -- 10.1073/pnas.0809414106 Crossref 10.1073/pnas.0809414106 -- missing cx lookup -- 10.1016/j.cell.2012.02.035 Crossref 10.1016/j.cell.2012.02.035 -- missing cx lookup -- 10.1074/jbc.R112.378877 Crossref 10.1074/jbc.R112.378877 -- missing cx lookup -- 10.1038/ni.2550 Crossref 10.1038/ni.2550 -- missing cx lookup -- 10.1016/j.cell.2013.02.054 Crossref 10.1016/j.cell.2013.02.054 -- missing cx lookup -- 10.1038/nature11986 Crossref 10.1038/nature11986 -- missing cx lookup -- 10.1073/pnas.0507900102 Crossref 10.1073/pnas.0507900102 -- missing cx lookup -- 10.1073/pnas.0611496104 Crossref 10.1073/pnas.0611496104 -- missing cx lookup -- 10.1016/j.str.2010.04.001 Crossref 10.1016/j.str.2010.04.001 -- missing cx lookup -- 10.1016/j.cell.2010.03.017 Crossref 10.1016/j.cell.2010.03.017 -- missing cx lookup -- 10.1523/JNEUROSCI.4088-10.2010 Crossref 10.1523/JNEUROSCI.4088-10.2010 -- missing cx lookup -- 10.1126/scisignal.2002767 Crossref 10.1126/scisignal.2002767 -- missing cx lookup -- 10.1083/jcb.200903124 Crossref 10.1083/jcb.200903124 -- missing cx lookup -- 10.1074/jbc.M109.082305 Crossref 10.1074/jbc.M109.082305