136957 20240614154057.0 10.1016/j.bcp.2012.12.007 doi pmid:23291240 pmid 0006-2952 ISSN 1873-2968 ISSN altmetric:6726000 altmetric DZNE-2020-03279 English 610 Popp, Julius P:(DE-HGF)0 0 Cerebral and extracerebral cholesterol metabolism and CSF markers of Alzheimer's disease. Amsterdam [u.a.] 2013 Elsevier Science print Crossref Elsevier BV 2013-07-01 article DRIVER Output Types/Journal article DataCite Journal Article journal journal PUB:(DE-HGF)16 1718372417_616 PUB:(DE-HGF) ARTICLE BibTeX JOURNAL_ARTICLE ORCID Journal Article 0 EndNote The disturbances of the cholesterol synthesis and metabolism described in Alzheimer's disease (AD) may be both a consequence of the neurodegenerative process and a contributor to the pathogenesis. These putative relationships and their underlying mechanisms are not well understood. The aim of this study was to evaluate the relationship between the cerebral and extracerebral cholesterol synthesis and metabolism, and the AD pathology as reflected by CSF markers in humans. We evaluated the relationships between the plasma and the cerebrospinal fluid (CSF) concentrations of cholesterol, the cholesterol precursors lanosterol, lathosterol and desmosterol, and the cholesterol elimination products 24S-hydroxycholesterol and 27-hydroxycholesterol, and the CSF markers for AD pathology Aβ1-42 and p-tau181 in 86 subjects with normal cognition and in 107 AD patients. CSF desmosterol, cholesterol and 24S-hydroxycholesterol in the AD group, and CSF 24S-hydroxycholesterol in the control group correlated with the p-tau181 levels. Neither CSF nor plasma concentrations of the included compounds correlated with the CSF Aβ1-42 levels. In multivariate regression tests including age, gender, albumin ratio, number of the APOEε4 alleles, and diagnosis, p-tau181 levels independently predicted the CSF desmosterol, cholesterol and 24S-hydroxycholesterol concentrations. The associations remained significant for CSF cholesterol and 24S-hydroxycholesterol when analyses were separately performed in the AD group. The results suggest that alterations of CNS cholesterol de novo genesis and metabolism are related to neurodegeneration and in particular to the cerebral accumulation of phosphorylated tau. 344 - Clinical and Health Care Research (POF3-344) G:(DE-HGF)POF3-344 POF3-344 POF III 0 2013-07-01 Crossref https://www.elsevier.com/tdm/userlicense/1.0/ Dataset connected to CrossRef, PubMed, Amyloid NLM Chemicals Biomarkers NLM Chemicals tau Proteins NLM Chemicals Cholesterol 97C5T2UQ7J NLM Chemicals Aged MeSH Alzheimer Disease: blood MeSH Alzheimer Disease: cerebrospinal fluid MeSH Alzheimer Disease: metabolism MeSH Amyloid: metabolism MeSH Biomarkers: blood MeSH Biomarkers: cerebrospinal fluid MeSH Brain: metabolism MeSH Case-Control Studies MeSH Cholesterol: metabolism MeSH Female MeSH Humans MeSH Male MeSH tau Proteins: metabolism MeSH Meichsner, Sabrina P:(DE-HGF)0 1 Kölsch, Heike P:(DE-HGF)0 2 Lewczuk, Piotr P:(DE-HGF)0 3 Maier, Wolfgang P:(DE-2719)2000015 4 dzne Kornhuber, Johannes P:(DE-HGF)0 5 Jessen, Frank P:(DE-2719)2000032 6 dzne Lütjohann, Dieter P:(DE-HGF)0 7 10.1016/j.bcp.2012.12.007 : Elsevier BV, 2013-07-01 1 37-42 journal-article Crossref Biochemical Pharmacology 86 2013 0006-2952 10.1016/j.bcp.2012.12.007 Vol. 86, no. 1, p. 37 - 42 PERI:(DE-600)1496199-4 1 86:1<37 - 42 37-42 Biochemical pharmacology 86 2013 0006-2952 http://pub.dzne.de/record/136957/files/DZNE-2020-03279_Restricted.pdf http://pub.dzne.de/record/136957/files/DZNE-2020-03279_Restricted.pdf?subformat=pdfa pdfa VDB oai:pub.dzne.de:136957 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 4 P:(DE-2719)2000015 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 6 P:(DE-2719)2000032 DE-HGF Gesundheit Erkrankungen des Nervensystems G:(DE-HGF)POF3-340 G:(DE-HGF)POF3-344 G:(DE-HGF)POF3 G:(DE-HGF)POF3-300 G:(DE-HGF)POF Clinical and Health Care Research 0 2013 Nationallizenz StatID:(DE-HGF)0420 StatID DBCoverage StatID:(DE-HGF)0300 StatID Medline DBCoverage StatID:(DE-HGF)0310 StatID NCBI Molecular Biology Database JCR StatID:(DE-HGF)0100 StatID BIOCHEM PHARMACOL : 2017 DBCoverage StatID:(DE-HGF)0200 StatID SCOPUS DBCoverage StatID:(DE-HGF)0600 StatID Ebsco Academic Search Peer Review StatID:(DE-HGF)0030 StatID ASC DBCoverage StatID:(DE-HGF)0199 StatID Clarivate Analytics Master Journal List WoS StatID:(DE-HGF)0110 StatID Science Citation Index DBCoverage StatID:(DE-HGF)0150 StatID Web of Science Core Collection WoS StatID:(DE-HGF)0111 StatID Science Citation Index Expanded DBCoverage StatID:(DE-HGF)1030 StatID Current Contents - Life Sciences DBCoverage StatID:(DE-HGF)1050 StatID BIOSIS Previews IF < 5 StatID:(DE-HGF)9900 StatID I:(DE-2719)999999 Pre 2020 DZNE before 2020 0 I:(DE-2719)7000001 U Clinical Researchers - Bonn U Clinical Researchers - Bonn 1 I:(DE-2719)1011102 AG Jessen Clinical Alzheimer’s Disease Research 2 journal VDB I:(DE-2719)999999 I:(DE-2719)7000001 I:(DE-2719)1011102 UNRESTRICTED