137143 20240321220210.0 10.1371/journal.pone.0081093 doi pmid:24278382 pmid pmc:PMC3836742 pmc altmetric:1938181 altmetric DZNE-2020-03465 English 610 Acosta-Cabronero, Julio P:(DE-2719)2810751 0 First author dzne In vivo quantitative susceptibility mapping (QSM) in Alzheimer's disease. San Francisco, California, US 2013 PLOS online Crossref Public Library of Science (PLoS) 2013-11-21 article DRIVER Output Types/Journal article DataCite Journal Article journal journal PUB:(DE-HGF)16 1709713541_11501 PUB:(DE-HGF) ARTICLE BibTeX JOURNAL_ARTICLE ORCID Journal Article 0 EndNote This study explores the magnetostatic properties of the Alzheimer's disease brain using a recently proposed, magnetic resonance imaging, postprocessed contrast mechanism. Quantitative susceptibility mapping (QSM) has the potential to monitor in vivo iron levels by reconstructing magnetic susceptibility sources from field perturbations. However, with phase data acquired at a single head orientation, the technique relies on several theoretical approximations and requires fast-evolving regularisation strategies.In this context, the present study describes a complete methodological framework for magnetic susceptibility measurements with a review of its theoretical foundations.The regional and whole-brain cross-sectional comparisons between Alzheimer's disease subjects and matched controls indicate that there may be significant magnetic susceptibility differences for deep brain nuclei--particularly the putamen--as well as for posterior grey and white matter regions. The methodology and findings described suggest that the QSM method is ready for larger-scale clinical studies. 344 - Clinical and Health Care Research (POF3-344) G:(DE-HGF)POF3-344 POF3-344 POF III 0 2013-11-21 Crossref http://creativecommons.org/licenses/by/3.0/ Dataset connected to CrossRef, PubMed, Adult MeSH Aged MeSH Alzheimer Disease: diagnosis MeSH Brain: pathology MeSH Brain Mapping MeSH Case-Control Studies MeSH Female MeSH Humans MeSH Image Interpretation, Computer-Assisted: methods MeSH Image Processing, Computer-Assisted: methods MeSH Magnetic Resonance Imaging: methods MeSH Male MeSH Reproducibility of Results MeSH Williams, Guy B 1 Cardenas-Blanco, Arturo P:(DE-2719)2810750 2 dzne Arnold, Robert J 3 Lupson, Victoria 4 Nestor, Peter J P:(DE-2719)2810673 5 Last author dzne 10.1371/journal.pone.0081093 : Public Library of Science (PLoS), 2013-11-21 11 e81093 journal-article Crossref PLoS ONE 8 2013 1932-6203 10.1371/journal.pone.0081093 Vol. 8, no. 11, p. e81093 - PERI:(DE-600)2267670-3 11 8:11<e81093 - e81093 PLOS ONE 8 2013 1932-6203 https://journals.plos.org/plosone/article/figure?id=10.1371/journal.pone.0081093.g001 Pubmed Central http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3836742 http://pub.dzne.de/record/137143/files/1942.PDF OpenAccess http://pub.dzne.de/record/137143/files/1942.gif?subformat=icon icon OpenAccess http://pub.dzne.de/record/137143/files/1942.jpg?subformat=icon-1440 icon-1440 OpenAccess http://pub.dzne.de/record/137143/files/1942.jpg?subformat=icon-180 icon-180 OpenAccess http://pub.dzne.de/record/137143/files/1942.jpg?subformat=icon-640 icon-640 OpenAccess oai:pub.dzne.de:137143 openaire open_access VDB driver dnbdelivery Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 0 P:(DE-2719)2810751 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 2 P:(DE-2719)2810750 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 5 P:(DE-2719)2810673 DE-HGF Gesundheit Erkrankungen des Nervensystems G:(DE-HGF)POF3-340 G:(DE-HGF)POF3-344 G:(DE-HGF)POF3 G:(DE-HGF)POF3-300 G:(DE-HGF)POF Clinical and Health Care Research 0 2013 DBCoverage StatID:(DE-HGF)0200 StatID SCOPUS Creative Commons Attribution CC BY (No Version) LIC:(DE-HGF)CCBYNV V:(DE-HGF) DOAJ DBCoverage StatID:(DE-HGF)1050 StatID BIOSIS Previews DBCoverage StatID:(DE-HGF)0600 StatID Ebsco Academic Search DBCoverage StatID:(DE-HGF)1040 StatID Zoological Record JCR StatID:(DE-HGF)0100 StatID PLOS ONE : 2017 DBCoverage StatID:(DE-HGF)0501 StatID DOAJ Seal DBCoverage StatID:(DE-HGF)0500 StatID DOAJ WoS StatID:(DE-HGF)0111 StatID Science Citation Index Expanded DBCoverage StatID:(DE-HGF)0150 StatID Web of Science Core Collection IF < 5 StatID:(DE-HGF)9900 StatID OpenAccess StatID:(DE-HGF)0510 StatID Peer Review StatID:(DE-HGF)0030 StatID ASC DBCoverage StatID:(DE-HGF)0310 StatID NCBI Molecular Biology Database DBCoverage StatID:(DE-HGF)0300 StatID Medline DBCoverage StatID:(DE-HGF)0320 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