137332 20240321220230.0 10.1523/JNEUROSCI.4342-13.2014 doi pmid:24672009 pmid pmc:PMC6608122 pmc 0270-6474 ISSN 1529-2401 ISSN altmetric:2214768 altmetric DZNE-2020-03654 English 610 Ritter, Christoph P:(DE-HGF)0 0 Corresponding author Representation of spatial information in key areas of the descending pain modulatory system. Washington, DC 2014 Soc.57413 online Crossref Society for Neuroscience 2014-03-26 print Crossref Society for Neuroscience 2014-03-26 article DRIVER Output Types/Journal article DataCite Journal Article journal journal PUB:(DE-HGF)16 1588080386_27436 PUB:(DE-HGF) ARTICLE BibTeX JOURNAL_ARTICLE ORCID Journal Article 0 EndNote Behavioral studies have demonstrated that descending pain modulation can be spatially specific, as is evident in placebo analgesia, which can be limited to the location at which pain relief is expected. This suggests that higher-order cortical structures of the descending pain modulatory system carry spatial information about the site of stimulation. Here, we used functional magnetic resonance imaging and multivariate pattern analysis in 15 healthy human volunteers to test whether spatial information of painful stimuli is represented in areas of the descending pain modulatory system. We show that the site of nociceptive stimulation (arm or leg) can be successfully decoded from local patterns of brain activity during the anticipation and receipt of painful stimulation in the rostral anterior cingulate cortex, the dorsolateral prefrontal cortices, and the contralateral parietal operculum. These results demonstrate that information regarding the site of nociceptive stimulation is represented in these brain regions. Attempts to predict arm and leg stimulation from the periaqueductal gray, control regions (e.g., white matter) or the control time interval in the intertrial phase did not allow for classifications above chance level. This finding represents an important conceptual advance in the understanding of endogenous pain control mechanisms by bridging the gap between previous behavioral and neuroimaging studies, suggesting a spatial specificity of endogenous pain control. 344 - Clinical and Health Care Research (POF3-344) G:(DE-HGF)POF3-344 POF3-344 POF III 0 2014-09-26 Crossref https://creativecommons.org/licenses/by-nc-sa/4.0/ Dataset connected to CrossRef, PubMed, Adult MeSH Arm: innervation MeSH Brain: blood supply MeSH Brain: physiopathology MeSH Brain Mapping MeSH Cues MeSH Female MeSH Functional Laterality MeSH Healthy Volunteers MeSH Humans MeSH Leg: innervation MeSH Male MeSH Neural Pathways: blood supply MeSH Neural Pathways: physiopathology MeSH Nociception: physiology MeSH Pain: pathology MeSH Pain: physiopathology MeSH Pain Measurement MeSH Pain Threshold: physiology MeSH Time Factors MeSH Young Adult MeSH Hebart, Martin N P:(DE-HGF)0 1 Wolbers, Thomas P:(DE-2719)2810583 2 dzne Bingel, Ulrike P:(DE-HGF)0 3 10.1523/jneurosci.4342-13.2014 Society for Neuroscience 2014-03-26 13 4634-4639 journal-article Crossref The Journal of Neuroscience 34 2014 0270-6474 10.1523/JNEUROSCI.4342-13.2014 Vol. 34, no. 13, p. 4634 - 4639 PERI:(DE-600)1475274-8 13 34:13<4634 - 4639 4634-4639 The journal of neuroscience 34 2014 0270-6474 Pubmed Central http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6608122 oai:pub.dzne.de:137332 VDB Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 2 P:(DE-2719)2810583 DE-HGF Forschungsbereich Gesundheit Erkrankungen des Nervensystems G:(DE-HGF)POF3-340 G:(DE-HGF)POF3-344 G:(DE-HGF)POF3-300 Clinical and Health Care Research 0 2014 JCR StatID:(DE-HGF)0100 StatID J NEUROSCI : 2017 DBCoverage StatID:(DE-HGF)0200 StatID SCOPUS DBCoverage StatID:(DE-HGF)0300 StatID Medline DBCoverage StatID:(DE-HGF)0310 StatID NCBI Molecular Biology Database DBCoverage StatID:(DE-HGF)0320 StatID PubMed Central DBCoverage StatID:(DE-HGF)0600 StatID Ebsco Academic Search Peer Review StatID:(DE-HGF)0030 StatID ASC DBCoverage StatID:(DE-HGF)0199 StatID Clarivate Analytics Master Journal List WoS StatID:(DE-HGF)0110 StatID Science Citation Index DBCoverage StatID:(DE-HGF)0150 StatID Web of Science Core Collection WoS StatID:(DE-HGF)0111 StatID Science Citation Index Expanded DBCoverage StatID:(DE-HGF)1030 StatID Current Contents - Life Sciences DBCoverage StatID:(DE-HGF)1050 StatID BIOSIS Previews IF >= 5 StatID:(DE-HGF)9905 StatID J NEUROSCI : 2017 I:(DE-2719)1310002 AG Wolbers Aging & Cognition 0 journal VDB I:(DE-2719)1310002 UNRESTRICTED 10.1016/j.neuroimage.2006.06.030 -- missing cx lookup -- Crossref 10.1523/JNEUROSCI.19-09-03639.1999 -- missing cx lookup -- Benedetti 3639 - Crossref J Neurosci 19 1999 10.1152/physiol.00024.2008 -- missing cx lookup -- Crossref 10.1016/j.neuroimage.2004.05.021 -- missing cx lookup -- Crossref 10.1016/j.neuroimage.2012.08.035 -- missing cx lookup -- Crossref 10.1016/j.neuroimage.2005.03.041 -- missing cx lookup -- Crossref 10.1016/S1364-6613(00)01483-2 -- missing cx lookup -- Crossref 10.1145/1961189.1961199 -- missing cx lookup -- Chang 27:21 - Crossref ACM Transactions on Intelligent Systems and Technology 2 2011 10.1126/science.1180142 -- missing cx lookup -- Crossref 10.1016/B0-443-07287-6/50012-6 -- missing cx lookup -- Crossref Fields HL Basbaum AI Heinricher MM (2006) in Wall and Melzack's textbook of pain, Central nervous system mechanisms of pain modulation, eds McMahon SB Koltzenburg M (Elsevier, London), pp 125–152. 10.1016/S0140-6736(00)47063-7 -- missing cx lookup -- Crossref 10.1136/jnnp.39.11.1071 -- missing cx lookup -- Crossref 10.1080/0964704X.2012.757965 -- missing cx lookup -- Crossref 10.1371/journal.pbio.0060187 -- missing cx lookup -- Crossref 10.1038/nrn1931 -- missing cx lookup -- Crossref 10.1016/j.brainresrev.2008.12.009 -- missing cx lookup -- Crossref 10.1016/j.cub.2006.04.003 -- missing cx lookup -- Crossref 10.1016/0006-8993(86)90025-9 -- missing cx lookup -- Crossref 10.1016/j.pain.2009.09.033 -- missing cx lookup -- Crossref 10.1016/S0301-0082(02)00009-6 -- missing cx lookup -- Crossref 10.1111/j.1467-9280.1996.tb00352.x -- missing cx lookup -- Crossref 10.1016/j.pain.2012.11.008 -- missing cx lookup -- Crossref 10.1016/j.tics.2006.07.005 -- missing cx lookup -- Crossref 10.1016/j.neuroimage.2009.02.047 -- missing cx lookup -- Crossref 10.1093/brain/60.4.389 -- missing cx lookup -- Crossref 10.1016/j.neuroimage.2008.11.007 -- missing cx lookup -- Crossref 10.1016/j.pain.2006.01.041 -- missing cx lookup -- Crossref 10.1016/j.neuroimage.2010.04.011 -- missing cx lookup -- Crossref 10.1016/0006-8993(82)90747-8 -- missing cx lookup -- Crossref 10.1016/j.pain.2012.07.010 -- missing cx lookup -- Crossref 10.1016/j.cell.2012.03.004 -- missing cx lookup -- Crossref 10.1016/j.neuron.2007.07.012 -- missing cx lookup -- Crossref 10.1016/j.tics.2008.05.005 -- missing cx lookup -- Crossref