137404 20240615120622.0 10.1002/embj.201387637 doi pmid:24719207 pmid pmc:PMC4193930 pmc 0261-4189 ISSN 1460-2075 ISSN altmetric:2272692 altmetric DZNE-2020-03726 English 570 Fischer, Andre P:(DE-2719)2000047 0 First author dzne Epigenetic memory: the Lamarckian brain. Hoboken, NJ [u.a.] 2014 Wiley online Crossref Wiley 2014-04-09 print Crossref Wiley 2014-05-02 article DRIVER Output Types/Journal article DataCite Journal Article journal journal PUB:(DE-HGF)16 1718374988_615 PUB:(DE-HGF) Review Article ARTICLE BibTeX JOURNAL_ARTICLE ORCID Journal Article 0 EndNote Recent data support the view that epigenetic processes play a role in memory consolidation and help to transmit acquired memories even across generations in a Lamarckian manner. Drugs that target the epigenetic machinery were found to enhance memory function in rodents and ameliorate disease phenotypes in models for brain diseases such as Alzheimer's disease, Chorea Huntington, Depression or Schizophrenia. In this review, I will give an overview on the current knowledge of epigenetic processes in memory function and brain disease with a focus on Morbus Alzheimer as the most common neurodegenerative disease. I will address the question whether an epigenetic therapy could indeed be a suitable therapeutic avenue to treat brain diseases and discuss the necessary steps that should help to take neuroepigenetic research to the next level. 342 - Disease Mechanisms and Model Systems (POF3-342) G:(DE-HGF)POF3-342 POF3-342 POF III 0 2015-09-01 Crossref http://doi.wiley.com/10.1002/tdm_license_1.1 Dataset connected to CrossRef, PubMed, Histones NLM Chemicals RNA, Untranslated NLM Chemicals Alzheimer Disease: genetics MeSH Alzheimer Disease: physiopathology MeSH Animals MeSH Brain: physiopathology MeSH Epigenesis, Genetic MeSH Gene Expression Regulation MeSH Histones: metabolism MeSH Humans MeSH Memory MeSH RNA, Untranslated: physiology MeSH 10.1002/embj.201387637 : Wiley, 2014-04-09 9 945-967 journal-article Crossref The EMBO Journal 33 2014 0261-4189 10.1002/embj.201387637 Vol. 33, no. 9, p. 945 - 967 PERI:(DE-600)1467419-1 9 33:9<945 - 967 945-967 The EMBO journal 33 2014 0261-4189 OpenAccess http://pub.dzne.de/record/137404/files/DZNE-2020-03726.pdf OpenAccess pdfa http://pub.dzne.de/record/137404/files/DZNE-2020-03726.pdf?subformat=pdfa Pubmed Central http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4193930 oai:pub.dzne.de:137404 openaire open_access VDB driver dnbdelivery Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 0 P:(DE-2719)2000047 DE-HGF Gesundheit Erkrankungen des Nervensystems G:(DE-HGF)POF3-340 G:(DE-HGF)POF3-342 G:(DE-HGF)POF3 G:(DE-HGF)POF3-300 G:(DE-HGF)POF Disease Mechanisms and Model Systems 0 2014 Creative Commons Attribution-NonCommercial-NoDerivs CC BY-NC-ND 3.0 LIC:(DE-HGF)CCBYNCND3 HGFVOC DBCoverage StatID:(DE-HGF)0200 StatID SCOPUS DBCoverage StatID:(DE-HGF)1030 StatID Current Contents - Life Sciences DBCoverage StatID:(DE-HGF)0600 StatID Ebsco Academic Search JCR StatID:(DE-HGF)0100 StatID EMBO J : 2017 IF >= 10 StatID:(DE-HGF)9910 StatID EMBO J : 2017 DBCoverage StatID:(DE-HGF)0150 StatID Web of Science Core Collection WoS StatID:(DE-HGF)0110 StatID Science Citation Index WoS StatID:(DE-HGF)0111 StatID Science Citation Index Expanded OpenAccess StatID:(DE-HGF)0510 StatID Peer Review StatID:(DE-HGF)0030 StatID ASC DBCoverage StatID:(DE-HGF)0310 StatID NCBI Molecular Biology Database DBCoverage StatID:(DE-HGF)1050 StatID BIOSIS Previews DBCoverage StatID:(DE-HGF)0300 StatID Medline DBCoverage StatID:(DE-HGF)0320 StatID PubMed Central DBCoverage StatID:(DE-HGF)0199 StatID Clarivate Analytics Master Journal List I:(DE-2719)1410002 AG Fischer Epigenetics and Systems Medicine in Neurodegenerative Diseases 0 journal VDB UNRESTRICTED I:(DE-2719)1410002 FullTexts