137719 20240321220312.0 10.1016/j.neurobiolaging.2014.04.003 doi pmid:24952995 pmid 0197-4580 ISSN 1558-1497 ISSN altmetric:2488415 altmetric DZNE-2020-04041 English 610 Bates, Sarah P:(DE-2719)2810641 0 First author How cognitive aging affects multisensory integration of navigational cues. Amsterdam [u.a.] 2014 Elsevier Science print Crossref Elsevier BV 2014-12-01 article DRIVER Output Types/Journal article DataCite Journal Article journal journal PUB:(DE-HGF)16 1707926545_4695 PUB:(DE-HGF) ARTICLE BibTeX JOURNAL_ARTICLE ORCID Journal Article 0 EndNote Entorhinal grid cells and hippocampal place cells are key systems for mammalian navigation. By combining information from different sensory modalities, they provide abstract representations of space. Given that both structures are among the earliest to undergo age-related neurodegenerative changes, we asked whether age-related navigational impairments are related to deficient integration of navigational cues. Younger and older adults performed a homing task that required using visual landmarks, self-motion information, or a combination of both. Further, a conflict between cues assessed the influence of each sensory domain. Our findings revealed performance impairments in the older adults, suggestive of a higher noise in the underlying spatial representations. In addition, even though both groups integrated visual and self-motion information to become more accurate and precise, older adults did not place as much influence on visual information as would have been optimal. As these findings were unrelated to potential changes in balance or spatial working memory, this study provides the first evidence that increasing noise and a suboptimal weighting of navigational cues might contribute to the common problems with spatial representations experienced by many older adults. These findings are discussed in the context of the known age-related changes in the entorhinal-hippocampal network. 344 - Clinical and Health Care Research (POF3-344) G:(DE-HGF)POF3-344 POF3-344 POF III 0 2014-12-01 Crossref https://www.elsevier.com/tdm/userlicense/1.0/ Dataset connected to CrossRef, PubMed, Adult MeSH Aged MeSH Aged, 80 and over MeSH Aging: pathology MeSH Aging: physiology MeSH Aging: psychology MeSH Animals MeSH Cognition: physiology MeSH Cues MeSH Entorhinal Cortex: cytology MeSH Entorhinal Cortex: pathology MeSH Entorhinal Cortex: physiology MeSH Female MeSH Hippocampus: cytology MeSH Hippocampus: pathology MeSH Hippocampus: physiology MeSH Homing Behavior: physiology MeSH Humans MeSH Male MeSH Middle Aged MeSH Noise MeSH Sensation: physiology MeSH Spatial Memory: physiology MeSH Spatial Navigation: physiology MeSH Visual Perception: physiology MeSH Young Adult MeSH Wolbers, Thomas P:(DE-2719)2810583 1 Last author 10.1016/j.neurobiolaging.2014.04.003 : Elsevier BV, 2014-12-01 12 2761-2769 journal-article Crossref Neurobiology of Aging 35 2014 0197-4580 10.1016/j.neurobiolaging.2014.04.003 Vol. 35, no. 12, p. 2761 - 2769 PERI:(DE-600)1498414-3 12 35:12<2761 - 2769 2761-2769 Neurobiology of aging 35 2014 0197-4580 http://pub.dzne.de/record/137719/files/DZNE-2020-04041_Restricted.pdf http://pub.dzne.de/record/137719/files/DZNE-2020-04041_Restricted.pdf?subformat=pdfa pdfa VDB oai:pub.dzne.de:137719 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 0 P:(DE-2719)2810641 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 1 P:(DE-2719)2810583 DE-HGF Gesundheit Erkrankungen des Nervensystems G:(DE-HGF)POF3-340 G:(DE-HGF)POF3-344 G:(DE-HGF)POF3 G:(DE-HGF)POF3-300 G:(DE-HGF)POF Clinical and Health Care Research 0 2014 Nationallizenz StatID:(DE-HGF)0420 StatID DBCoverage StatID:(DE-HGF)0300 StatID Medline DBCoverage StatID:(DE-HGF)0310 StatID NCBI Molecular Biology Database JCR StatID:(DE-HGF)0100 StatID NEUROBIOL AGING : 2017 DBCoverage StatID:(DE-HGF)0200 StatID SCOPUS DBCoverage StatID:(DE-HGF)0600 StatID Ebsco Academic Search Peer Review StatID:(DE-HGF)0030 StatID ASC DBCoverage StatID:(DE-HGF)0199 StatID Clarivate Analytics Master Journal List WoS StatID:(DE-HGF)0110 StatID Science Citation Index DBCoverage StatID:(DE-HGF)0150 StatID Web of Science Core Collection WoS StatID:(DE-HGF)0111 StatID Science Citation Index Expanded DBCoverage StatID:(DE-HGF)1030 StatID Current Contents - Life Sciences DBCoverage StatID:(DE-HGF)1050 StatID BIOSIS Previews IF < 5 StatID:(DE-HGF)9900 StatID I:(DE-2719)1310002 AG Wolbers Aging, Cognition and Technology 0 journal VDB I:(DE-2719)1310002 UNRESTRICTED