137830 20240321220326.0 10.1016/j.cortex.2014.12.007 doi pmid:25597525 pmid pmc:PMC4884644 pmc 0010-9452 ISSN 1973-8102 ISSN altmetric:3037261 altmetric DZNE-2020-04152 English 610 Vieweg, Paula P:(DE-2719)2810529 0 First author dzne Changes in pattern completion--a key mechanism to explain age-related recognition memory deficits? New York, NY 2015 Elsevier print Crossref Elsevier BV 2015-03-01 article DRIVER Output Types/Journal article DataCite Journal Article journal journal PUB:(DE-HGF)16 1710430196_24480 PUB:(DE-HGF) ARTICLE BibTeX JOURNAL_ARTICLE ORCID Journal Article 0 EndNote Accurate memory retrieval from partial or degraded input requires the reactivation of memory traces, a hippocampal mechanism termed pattern completion. Age-related changes in hippocampal integrity have been hypothesized to shift the balance of memory processes in favor of the retrieval of already stored information (pattern completion), to the detriment of encoding new events (pattern separation). Using a novel behavioral paradigm, we investigated the impact of cognitive aging (1) on recognition performance across different levels of stimulus completeness, and (2) on potential response biases. Participants were required to identify previously learned scenes among new ones. Additionally, all stimuli were presented in gradually masked versions to alter stimulus completeness. Both young and older adults performed increasingly poorly as the scenes became less complete, and this decline in performance was more pronounced in elderly participants indicative of a pattern completion deficit. Intriguingly, when novel scenes were shown, only the older adults showed an increased tendency to identify these as familiar scenes. In line with theoretical models, we argue that this reflects an age-related bias towards pattern completion. 344 - Clinical and Health Care Research (POF3-344) G:(DE-HGF)POF3-344 POF3-344 POF III 0 2015-03-01 Crossref https://www.elsevier.com/tdm/userlicense/1.0/ Dataset connected to CrossRef, PubMed, Adult MeSH Aged MeSH Aging: physiology MeSH Attention: physiology MeSH Female MeSH Humans MeSH Male MeSH Memory: physiology MeSH Memory Disorders: physiopathology MeSH Mental Recall: physiology MeSH Middle Aged MeSH Neuropsychological Tests MeSH Photic Stimulation MeSH Reaction Time: physiology MeSH Young Adult MeSH Stangl, Matthias P:(DE-2719)2810620 1 dzne Howard, Lorelei R P:(DE-2719)2810709 2 dzne Wolbers, Thomas P:(DE-2719)2810583 3 Last author dzne 10.1016/j.cortex.2014.12.007 : Elsevier BV, 2015-03-01 343-351 journal-article Crossref Cortex 64 2015 0010-9452 10.1016/j.cortex.2014.12.007 Vol. 64, p. 343 - 351 PERI:(DE-600)2080335-7 64<343 - 351 343-351 Cortex 64 2015 0010-9452 Pubmed Central http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4884644 http://pub.dzne.de/record/137830/files/DZNE-2020-04152_Restricted.pdf http://pub.dzne.de/record/137830/files/DZNE-2020-04152_Restricted.pdf?subformat=pdfa pdfa VDB oai:pub.dzne.de:137830 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 0 P:(DE-2719)2810529 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 1 P:(DE-2719)2810620 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 2 P:(DE-2719)2810709 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 3 P:(DE-2719)2810583 DE-HGF Gesundheit Erkrankungen des Nervensystems G:(DE-HGF)POF3-340 G:(DE-HGF)POF3-344 G:(DE-HGF)POF3 G:(DE-HGF)POF3-300 G:(DE-HGF)POF Clinical and Health Care Research 0 2015 DBCoverage StatID:(DE-HGF)0300 StatID Medline DBCoverage StatID:(DE-HGF)0310 StatID NCBI Molecular Biology Database JCR StatID:(DE-HGF)0100 StatID CORTEX : 2017 DBCoverage StatID:(DE-HGF)0200 StatID SCOPUS DBCoverage StatID:(DE-HGF)0199 StatID Clarivate Analytics Master Journal List WoS StatID:(DE-HGF)0110 StatID Science Citation Index DBCoverage StatID:(DE-HGF)0150 StatID Web of Science Core Collection WoS StatID:(DE-HGF)0111 StatID Science Citation Index Expanded DBCoverage StatID:(DE-HGF)1030 StatID Current Contents - Life Sciences DBCoverage StatID:(DE-HGF)1050 StatID BIOSIS Previews IF < 5 StatID:(DE-HGF)9900 StatID I:(DE-2719)1310002 AG Wolbers Aging, Cognition and Technology 0 journal VDB I:(DE-2719)1310002 UNRESTRICTED