Journal Article

DZNE-2020-04268

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Function and developmental origin of a mesocortical inhibitory circuit.

Kabanova, A. ; Pabst, M. ; Lorkowski, M. ; Braganza, O. ; Boehlen, A. ; Nikbakht, N. ; Pothmann, L. ; Vaswani, A. R. ; Musgrove, R.DZNE* ; Di Monte, D. A.DZNE* ; Sauvage, M. ; Beck, H.DZNE* ; Blaess, S. (Corresponding author)

2015
Nature Publ. Group58142 London

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Please use a persistent id in citations: doi:10.1038/nn.4020

Abstract: Midbrain ventral tegmental neurons project to the prefrontal cortex and modulate cognitive functions. Using viral tracing, optogenetics and electrophysiology, we found that mesocortical neurons in the mouse ventrotegmental area provide fast glutamatergic excitation of GABAergic interneurons in the prefrontal cortex and inhibit prefrontal cortical pyramidal neurons in a robust and reliable manner. These mesocortical neurons were derived from a subset of dopaminergic progenitors, which were dependent on prolonged Sonic Hedgehog signaling for their induction. Loss of these progenitors resulted in the loss of the mesocortical inhibitory circuit and an increase in perseverative behavior, whereas mesolimbic and mesostriatal dopaminergic projections, as well as impulsivity and attentional function, were largely spared. Thus, we identified a previously uncharacterized mesocortical circuit contributing to perseverative behaviors and found that the diversity of dopaminergic neurons begins to be established during their progenitor phase.

Keyword(s): Animals (MeSH) ; Attention: physiology (MeSH) ; Behavior, Animal: physiology (MeSH) ; Cognition: physiology (MeSH) ; Conditioning, Operant: physiology (MeSH) ; Dopaminergic Neurons: physiology (MeSH) ; Glutamates: physiology (MeSH) ; Interneurons: physiology (MeSH) ; Mice (MeSH) ; Nerve Net: growth & development (MeSH) ; Nerve Net: physiology (MeSH) ; Neurons: physiology (MeSH) ; Optogenetics (MeSH) ; Prefrontal Cortex: cytology (MeSH) ; Prefrontal Cortex: growth & development (MeSH) ; Prefrontal Cortex: physiology (MeSH) ; Pyramidal Cells: physiology (MeSH) ; Reward (MeSH) ; Ventral Tegmental Area: cytology (MeSH) ; Ventral Tegmental Area: growth & development (MeSH) ; Ventral Tegmental Area: physiology (MeSH) ; gamma-Aminobutyric Acid: physiology (MeSH) ; Glutamates ; gamma-Aminobutyric Acid

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Contributing Institute(s):

1. Neurodegeneration and Neuroprotection in Parkinson´s Disease (AG Di Monte)
2. U Preclinical Researchers - Bonn (U Preclinical Researchers - Bonn)

Research Program(s):

1. 342 - Disease Mechanisms and Model Systems (POF3-342) (POF3-342)

Appears in the scientific report 2015

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Database coverage:
; BIOSIS Previews ; BIOSIS Reviews Reports And Meetings ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; IF >= 15 ; IF >= 30 ; JCR ; NCBI Molecular Biology Database ; Nationallizenz ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Web of Science Core Collection

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