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000137946 0247_ $$2ISSN$$a1471-003X
000137946 0247_ $$2ISSN$$a1471-0048
000137946 0247_ $$2ISSN$$a1546-1726
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000137946 041__ $$aEnglish
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000137946 1001_ $$aKabanova, Anna$$b0
000137946 245__ $$aFunction and developmental origin of a mesocortical inhibitory circuit.
000137946 260__ $$aLondon$$bNature Publ. Group58142$$c2015
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000137946 520__ $$aMidbrain ventral tegmental neurons project to the prefrontal cortex and modulate cognitive functions. Using viral tracing, optogenetics and electrophysiology, we found that mesocortical neurons in the mouse ventrotegmental area provide fast glutamatergic excitation of GABAergic interneurons in the prefrontal cortex and inhibit prefrontal cortical pyramidal neurons in a robust and reliable manner. These mesocortical neurons were derived from a subset of dopaminergic progenitors, which were dependent on prolonged Sonic Hedgehog signaling for their induction. Loss of these progenitors resulted in the loss of the mesocortical inhibitory circuit and an increase in perseverative behavior, whereas mesolimbic and mesostriatal dopaminergic projections, as well as impulsivity and attentional function, were largely spared. Thus, we identified a previously uncharacterized mesocortical circuit contributing to perseverative behaviors and found that the diversity of dopaminergic neurons begins to be established during their progenitor phase.
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000137946 650_7 $$2NLM Chemicals$$aGlutamates
000137946 650_7 $$056-12-2$$2NLM Chemicals$$agamma-Aminobutyric Acid
000137946 650_2 $$2MeSH$$aAnimals
000137946 650_2 $$2MeSH$$aAttention: physiology
000137946 650_2 $$2MeSH$$aBehavior, Animal: physiology
000137946 650_2 $$2MeSH$$aCognition: physiology
000137946 650_2 $$2MeSH$$aConditioning, Operant: physiology
000137946 650_2 $$2MeSH$$aDopaminergic Neurons: physiology
000137946 650_2 $$2MeSH$$aGlutamates: physiology
000137946 650_2 $$2MeSH$$aInterneurons: physiology
000137946 650_2 $$2MeSH$$aMice
000137946 650_2 $$2MeSH$$aNerve Net: growth & development
000137946 650_2 $$2MeSH$$aNerve Net: physiology
000137946 650_2 $$2MeSH$$aNeurons: physiology
000137946 650_2 $$2MeSH$$aOptogenetics
000137946 650_2 $$2MeSH$$aPrefrontal Cortex: cytology
000137946 650_2 $$2MeSH$$aPrefrontal Cortex: growth & development
000137946 650_2 $$2MeSH$$aPrefrontal Cortex: physiology
000137946 650_2 $$2MeSH$$aPyramidal Cells: physiology
000137946 650_2 $$2MeSH$$aReward
000137946 650_2 $$2MeSH$$aVentral Tegmental Area: cytology
000137946 650_2 $$2MeSH$$aVentral Tegmental Area: growth & development
000137946 650_2 $$2MeSH$$aVentral Tegmental Area: physiology
000137946 650_2 $$2MeSH$$agamma-Aminobutyric Acid: physiology
000137946 7001_ $$aPabst, Milan$$b1
000137946 7001_ $$aLorkowski, Markus$$b2
000137946 7001_ $$aBraganza, Oliver$$b3
000137946 7001_ $$aBoehlen, Anne$$b4
000137946 7001_ $$aNikbakht, Negar$$b5
000137946 7001_ $$aPothmann, Leonie$$b6
000137946 7001_ $$aVaswani, Ankita R$$b7
000137946 7001_ $$0P:(DE-2719)2810507$$aMusgrove, Ruth$$b8$$udzne
000137946 7001_ $$0P:(DE-2719)2481741$$aDi Monte, Donato A$$b9$$udzne
000137946 7001_ $$aSauvage, Magdalena$$b10
000137946 7001_ $$0P:(DE-2719)2000044$$aBeck, Heinz$$b11$$udzne
000137946 7001_ $$0P:(DE-HGF)0$$aBlaess, Sandra$$b12$$eCorresponding author
000137946 77318 $$2Crossref$$3journal-article$$a10.1038/nn.4020$$b : Springer Science and Business Media LLC, 2015-05-11$$n6$$p872-882$$tNature Neuroscience$$v18$$x1097-6256$$y2015
000137946 773__ $$0PERI:(DE-600)2028902-9$$a10.1038/nn.4020$$gVol. 18, no. 6, p. 872 - 882$$n6$$p872-882$$q18:6<872 - 882$$tNature reviews / Neuroscience$$v18$$x1097-6256$$y2015
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000137946 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.neuron.2013.08.023$$o10.1016/j.neuron.2013.08.023
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