TY  - JOUR
AU  - Kabanova, Anna
AU  - Pabst, Milan
AU  - Lorkowski, Markus
AU  - Braganza, Oliver
AU  - Boehlen, Anne
AU  - Nikbakht, Negar
AU  - Pothmann, Leonie
AU  - Vaswani, Ankita R
AU  - Musgrove, Ruth
AU  - Di Monte, Donato A
AU  - Sauvage, Magdalena
AU  - Beck, Heinz
AU  - Blaess, Sandra
TI  - Function and developmental origin of a mesocortical inhibitory circuit.
JO  - Nature reviews / Neuroscience
VL  - 18
IS  - 6
SN  - 1097-6256
CY  - London
PB  - Nature Publ. Group58142
M1  - DZNE-2020-04268
SP  - 872-882
PY  - 2015
AB  - Midbrain ventral tegmental neurons project to the prefrontal cortex and modulate cognitive functions. Using viral tracing, optogenetics and electrophysiology, we found that mesocortical neurons in the mouse ventrotegmental area provide fast glutamatergic excitation of GABAergic interneurons in the prefrontal cortex and inhibit prefrontal cortical pyramidal neurons in a robust and reliable manner. These mesocortical neurons were derived from a subset of dopaminergic progenitors, which were dependent on prolonged Sonic Hedgehog signaling for their induction. Loss of these progenitors resulted in the loss of the mesocortical inhibitory circuit and an increase in perseverative behavior, whereas mesolimbic and mesostriatal dopaminergic projections, as well as impulsivity and attentional function, were largely spared. Thus, we identified a previously uncharacterized mesocortical circuit contributing to perseverative behaviors and found that the diversity of dopaminergic neurons begins to be established during their progenitor phase.
KW  - Animals
KW  - Attention: physiology
KW  - Behavior, Animal: physiology
KW  - Cognition: physiology
KW  - Conditioning, Operant: physiology
KW  - Dopaminergic Neurons: physiology
KW  - Glutamates: physiology
KW  - Interneurons: physiology
KW  - Mice
KW  - Nerve Net: growth & development
KW  - Nerve Net: physiology
KW  - Neurons: physiology
KW  - Optogenetics
KW  - Prefrontal Cortex: cytology
KW  - Prefrontal Cortex: growth & development
KW  - Prefrontal Cortex: physiology
KW  - Pyramidal Cells: physiology
KW  - Reward
KW  - Ventral Tegmental Area: cytology
KW  - Ventral Tegmental Area: growth & development
KW  - Ventral Tegmental Area: physiology
KW  - gamma-Aminobutyric Acid: physiology
KW  - Glutamates (NLM Chemicals)
KW  - gamma-Aminobutyric Acid (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:25961790
DO  - DOI:10.1038/nn.4020
UR  - https://pub.dzne.de/record/137946
ER  -