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| 001 | 137946 | ||
| 005 | 20240321220338.0 | ||
| 024 | 7 | _ | |a 10.1038/nn.4020 |2 doi |
| 024 | 7 | _ | |a pmid:25961790 |2 pmid |
| 024 | 7 | _ | |a 1097-6256 |2 ISSN |
| 024 | 7 | _ | |a 1471-003X |2 ISSN |
| 024 | 7 | _ | |a 1471-0048 |2 ISSN |
| 024 | 7 | _ | |a 1546-1726 |2 ISSN |
| 024 | 7 | _ | |a altmetric:3985847 |2 altmetric |
| 037 | _ | _ | |a DZNE-2020-04268 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 570 |
| 100 | 1 | _ | |a Kabanova, Anna |b 0 |
| 245 | _ | _ | |a Function and developmental origin of a mesocortical inhibitory circuit. |
| 260 | _ | _ | |a London |c 2015 |b Nature Publ. Group58142 |
| 264 | _ | 1 | |3 online |2 Crossref |b Springer Science and Business Media LLC |c 2015-05-11 |
| 264 | _ | 1 | |3 print |2 Crossref |b Springer Science and Business Media LLC |c 2015-06-01 |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1590670726_3940 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Midbrain ventral tegmental neurons project to the prefrontal cortex and modulate cognitive functions. Using viral tracing, optogenetics and electrophysiology, we found that mesocortical neurons in the mouse ventrotegmental area provide fast glutamatergic excitation of GABAergic interneurons in the prefrontal cortex and inhibit prefrontal cortical pyramidal neurons in a robust and reliable manner. These mesocortical neurons were derived from a subset of dopaminergic progenitors, which were dependent on prolonged Sonic Hedgehog signaling for their induction. Loss of these progenitors resulted in the loss of the mesocortical inhibitory circuit and an increase in perseverative behavior, whereas mesolimbic and mesostriatal dopaminergic projections, as well as impulsivity and attentional function, were largely spared. Thus, we identified a previously uncharacterized mesocortical circuit contributing to perseverative behaviors and found that the diversity of dopaminergic neurons begins to be established during their progenitor phase. |
| 536 | _ | _ | |a 342 - Disease Mechanisms and Model Systems (POF3-342) |0 G:(DE-HGF)POF3-342 |c POF3-342 |f POF III |x 0 |
| 542 | _ | _ | |i 2015-05-11 |2 Crossref |u http://www.springer.com/tdm |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, |
| 650 | _ | 7 | |a Glutamates |2 NLM Chemicals |
| 650 | _ | 7 | |a gamma-Aminobutyric Acid |0 56-12-2 |2 NLM Chemicals |
| 650 | _ | 2 | |a Animals |2 MeSH |
| 650 | _ | 2 | |a Attention: physiology |2 MeSH |
| 650 | _ | 2 | |a Behavior, Animal: physiology |2 MeSH |
| 650 | _ | 2 | |a Cognition: physiology |2 MeSH |
| 650 | _ | 2 | |a Conditioning, Operant: physiology |2 MeSH |
| 650 | _ | 2 | |a Dopaminergic Neurons: physiology |2 MeSH |
| 650 | _ | 2 | |a Glutamates: physiology |2 MeSH |
| 650 | _ | 2 | |a Interneurons: physiology |2 MeSH |
| 650 | _ | 2 | |a Mice |2 MeSH |
| 650 | _ | 2 | |a Nerve Net: growth & development |2 MeSH |
| 650 | _ | 2 | |a Nerve Net: physiology |2 MeSH |
| 650 | _ | 2 | |a Neurons: physiology |2 MeSH |
| 650 | _ | 2 | |a Optogenetics |2 MeSH |
| 650 | _ | 2 | |a Prefrontal Cortex: cytology |2 MeSH |
| 650 | _ | 2 | |a Prefrontal Cortex: growth & development |2 MeSH |
| 650 | _ | 2 | |a Prefrontal Cortex: physiology |2 MeSH |
| 650 | _ | 2 | |a Pyramidal Cells: physiology |2 MeSH |
| 650 | _ | 2 | |a Reward |2 MeSH |
| 650 | _ | 2 | |a Ventral Tegmental Area: cytology |2 MeSH |
| 650 | _ | 2 | |a Ventral Tegmental Area: growth & development |2 MeSH |
| 650 | _ | 2 | |a Ventral Tegmental Area: physiology |2 MeSH |
| 650 | _ | 2 | |a gamma-Aminobutyric Acid: physiology |2 MeSH |
| 700 | 1 | _ | |a Pabst, Milan |b 1 |
| 700 | 1 | _ | |a Lorkowski, Markus |b 2 |
| 700 | 1 | _ | |a Braganza, Oliver |b 3 |
| 700 | 1 | _ | |a Boehlen, Anne |b 4 |
| 700 | 1 | _ | |a Nikbakht, Negar |b 5 |
| 700 | 1 | _ | |a Pothmann, Leonie |b 6 |
| 700 | 1 | _ | |a Vaswani, Ankita R |b 7 |
| 700 | 1 | _ | |a Musgrove, Ruth |0 P:(DE-2719)2810507 |b 8 |u dzne |
| 700 | 1 | _ | |a Di Monte, Donato A |0 P:(DE-2719)2481741 |b 9 |u dzne |
| 700 | 1 | _ | |a Sauvage, Magdalena |b 10 |
| 700 | 1 | _ | |a Beck, Heinz |0 P:(DE-2719)2000044 |b 11 |u dzne |
| 700 | 1 | _ | |a Blaess, Sandra |0 P:(DE-HGF)0 |b 12 |e Corresponding author |
| 773 | 1 | 8 | |a 10.1038/nn.4020 |b : Springer Science and Business Media LLC, 2015-05-11 |n 6 |p 872-882 |3 journal-article |2 Crossref |t Nature Neuroscience |v 18 |y 2015 |x 1097-6256 |
| 773 | _ | _ | |a 10.1038/nn.4020 |g Vol. 18, no. 6, p. 872 - 882 |0 PERI:(DE-600)2028902-9 |n 6 |q 18:6<872 - 882 |p 872-882 |t Nature reviews / Neuroscience |v 18 |y 2015 |x 1097-6256 |
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