137972 20240321220341.0 10.7554/eLife.06426 doi pmid:26052749 pmid pmc:PMC4458841 pmc altmetric:4115791 altmetric DZNE-2020-04294 English 600 Maaß, Anne P:(DE-2719)2811815 0 First author Functional subregions of the human entorhinal cortex. Cambridge 2015 eLife Sciences Publications online Crossref eLife Sciences Publications, Ltd 2015-06-08 article DRIVER Output Types/Journal article DataCite Journal Article journal journal PUB:(DE-HGF)16 1709718365_11500 PUB:(DE-HGF) ARTICLE BibTeX JOURNAL_ARTICLE ORCID Journal Article 0 EndNote The entorhinal cortex (EC) is the primary site of interactions between the neocortex and hippocampus. Studies in rodents and nonhuman primates suggest that EC can be divided into subregions that connect differentially with perirhinal cortex (PRC) vs parahippocampal cortex (PHC) and with hippocampal subfields along the proximo-distal axis. Here, we used high-resolution functional magnetic resonance imaging at 7 Tesla to identify functional subdivisions of the human EC. In two independent datasets, PRC showed preferential intrinsic functional connectivity with anterior-lateral EC and PHC with posterior-medial EC. These EC subregions, in turn, exhibited differential connectivity with proximal and distal subiculum. In contrast, connectivity of PRC and PHC with subiculum followed not only a proximal-distal but also an anterior-posterior gradient. Our data provide the first evidence that the human EC can be divided into functional subdivisions whose functional connectivity closely parallels the known anatomical connectivity patterns of the rodent and nonhuman primate EC. 344 - Clinical and Health Care Research (POF3-344) G:(DE-HGF)POF3-344 POF3-344 POF III 0 2015-06-08 Crossref http://creativecommons.org/licenses/by/4.0/ Dataset connected to CrossRef, PubMed, Adult MeSH Connectome: methods MeSH Entorhinal Cortex: anatomy & histology MeSH Entorhinal Cortex: physiology MeSH Female MeSH Hippocampus: physiology MeSH Humans MeSH Magnetic Resonance Imaging MeSH Male MeSH Memory: physiology MeSH Neural Pathways: physiology MeSH Species Specificity MeSH Visual Perception: physiology MeSH Berron, David P:(DE-2719)2812972 1 Libby, Laura A P:(DE-HGF)0 2 Ranganath, Charan P:(DE-HGF)0 3 Düzel, Emrah P:(DE-2719)2000005 4 Last author 10.7554/elife.06426 : eLife Sciences Publications, Ltd, 2015-06-08 journal-article Crossref eLife 4 2015 2050-084X 10.7554/eLife.06426 Vol. 4, p. e06426 PERI:(DE-600)2687154-3 4<e06426 e06426 eLife 4 2015 2050-084X https://elifesciences.org/articles/06426#fig1 Pubmed Central http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4458841 http://pub.dzne.de/record/137972/files/656_fig.pdf http://pub.dzne.de/record/137972/files/656.pdf OpenAccess http://pub.dzne.de/record/137972/files/656_fig.pdf?subformat=pdfa pdfa http://pub.dzne.de/record/137972/files/656.pdf?subformat=pdfa pdfa OpenAccess oai:pub.dzne.de:137972 openaire open_access VDB driver dnbdelivery Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 0 P:(DE-2719)2811815 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 1 P:(DE-2719)2812972 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 4 P:(DE-2719)2000005 DE-HGF Gesundheit Erkrankungen des Nervensystems G:(DE-HGF)POF3-340 G:(DE-HGF)POF3-344 G:(DE-HGF)POF3 G:(DE-HGF)POF3-300 G:(DE-HGF)POF Clinical and Health Care Research 0 DE-HGF Programmungebundene Forschung ohne Programm G:(DE-HGF)POF4-890 G:(DE-HGF)POF4-899 G:(DE-HGF)POF4 G:(DE-HGF)POF4-800 G:(DE-HGF)POF ohne Topic 0 2015 DBCoverage StatID:(DE-HGF)0200 StatID SCOPUS Creative Commons Attribution CC BY (No Version) LIC:(DE-HGF)CCBYNV V:(DE-HGF) DOAJ DBCoverage StatID:(DE-HGF)1050 StatID BIOSIS Previews DBCoverage StatID:(DE-HGF)0600 StatID Ebsco Academic Search DBCoverage StatID:(DE-HGF)1040 StatID Zoological Record JCR StatID:(DE-HGF)0100 StatID ELIFE : 2017 DBCoverage StatID:(DE-HGF)0501 StatID DOAJ Seal DBCoverage StatID:(DE-HGF)0500 StatID DOAJ WoS StatID:(DE-HGF)0111 StatID Science Citation Index Expanded DBCoverage StatID:(DE-HGF)0150 StatID Web of Science Core Collection OpenAccess StatID:(DE-HGF)0510 StatID Peer Review StatID:(DE-HGF)0030 StatID ASC IF >= 5 StatID:(DE-HGF)9905 StatID ELIFE : 2017 DBCoverage StatID:(DE-HGF)0310 StatID NCBI Molecular Biology Database DBCoverage StatID:(DE-HGF)0300 StatID Medline DBCoverage StatID:(DE-HGF)0320 StatID PubMed Central DBCoverage StatID:(DE-HGF)0199 StatID Clarivate Analytics Master Journal List I:(DE-2719)5000006 AG Düzel Clinical Neurophysiology and Memory 0 journal VDB I:(DE-2719)5000006 UNRESTRICTED FullTexts -- missing cx lookup -- 10.1016/j.bbr.2013.07.005 Crossref 10.1016/j.bbr.2013.07.005 -- missing cx lookup -- 10.1016/j.neuroimage.2010.09.025 Crossref 10.1016/j.neuroimage.2010.09.025 -- missing cx lookup -- 10.1016/j.neuroimage.2009.09.062 Crossref 10.1016/j.neuroimage.2009.09.062 -- missing cx lookup -- 10.1073/pnas.1504394112 Crossref 10.1073/pnas.1504394112 -- missing cx lookup -- 10.1111/j.1750-3639.1991.tb00661.x Crossref 10.1111/j.1750-3639.1991.tb00661.x -- missing cx lookup -- 10.1016/j.neurobiolaging.2003.12.015 Crossref 10.1016/j.neurobiolaging.2003.12.015 -- missing cx lookup -- 10.1111/j.1749-6632.2000.tb06717.x Crossref 10.1111/j.1749-6632.2000.tb06717.x -- missing cx lookup -- 10.1093/cercor/6.2.81 Crossref 10.1093/cercor/6.2.81 -- missing cx lookup -- 10.1145/1961189.1961199 Crossref 10.1145/1961189.1961199 -- missing cx lookup -- 10.1016/j.pneurobio.2004.08.005 Crossref 10.1016/j.pneurobio.2004.08.005 -- missing cx lookup -- 10.1146/annurev.neuro.30.051606.094328 Crossref 10.1146/annurev.neuro.30.051606.094328 -- missing cx lookup -- 10.1016/j.neuroimage.2006.11.051 Crossref 10.1016/j.neuroimage.2006.11.051 -- missing cx lookup -- 10.1016/j.neuroimage.2009.04.033 Crossref 10.1016/j.neuroimage.2009.04.033 -- missing cx lookup -- 10.1038/nrn2201 Crossref 10.1038/nrn2201 -- missing cx lookup -- 10.1038/nn1616 Crossref 10.1038/nn1616 -- missing cx lookup -- 10.1007/s12021-008-9041-y Crossref 10.1007/s12021-008-9041-y -- missing cx lookup -- 10.1016/j.neuron.2010.08.042 Crossref 10.1016/j.neuron.2010.08.042 -- missing cx lookup -- 10.1002/hipo.22097 Crossref 10.1002/hipo.22097 -- missing cx lookup -- 10.1007/s10334-011-0275-6 Crossref 10.1007/s10334-011-0275-6 1998 Crossref Insausti 1998 -- missing cx lookup -- 10.1016/S1361-8415(01)00036-6 Crossref 10.1016/S1361-8415(01)00036-6 -- missing cx lookup -- 10.1152/jn.00077.2008 Crossref 10.1152/jn.00077.2008 -- missing cx lookup -- 10.1038/nn.3606 Crossref 10.1038/nn.3606 -- missing cx lookup -- 10.1038/nature11587 Crossref 10.1038/nature11587 -- missing cx lookup -- 10.1016/j.neuroimage.2008.12.037 Crossref 10.1016/j.neuroimage.2008.12.037 -- missing cx lookup -- 10.1101/lm.224606 Crossref 10.1101/lm.224606 -- missing cx lookup -- 10.1098/rstb.2013.0369 Crossref 10.1098/rstb.2013.0369 -- missing cx lookup -- 10.1016/j.neuron.2014.01.026 Crossref 10.1016/j.neuron.2014.01.026 -- missing cx lookup -- 10.1002/hipo.22047 Crossref 10.1002/hipo.22047 -- missing cx lookup -- 10.1002/1098-1063(2000)10:4<420::AID-HIPO8>3.0.CO;2-5 Crossref 10.1002/1098-1063(2000)10:4<420::AID-HIPO8>3.0.CO;2-5 -- missing cx lookup -- 10.1523/JNEUROSCI.3711-11.2012 Crossref 10.1523/JNEUROSCI.3711-11.2012 -- missing cx lookup -- 10.1038/ncomms6547 Crossref 10.1038/ncomms6547 -- missing cx lookup -- 10.1016/j.neuron.2013.09.043 Crossref 10.1016/j.neuron.2013.09.043 -- missing cx lookup -- 10.1002/hipo.1029 Crossref 10.1002/hipo.1029 -- missing cx lookup -- 10.1046/j.1460-9568.1999.00835.x Crossref 10.1046/j.1460-9568.1999.00835.x -- missing cx lookup -- 10.7554/eLife.06738 Crossref 10.7554/eLife.06738 -- missing cx lookup -- 10.1002/hbm.1058 Crossref 10.1002/hbm.1058 -- missing cx lookup -- 10.1002/cne.23417 Crossref 10.1002/cne.23417 -- missing cx lookup -- 10.1038/nrn3338 Crossref 10.1038/nrn3338 -- missing cx lookup -- 10.1073/pnas.1411250111 Crossref 10.1073/pnas.1411250111 -- missing cx lookup -- 10.1016/bs.pbr.2015.04.001 Crossref 10.1016/bs.pbr.2015.04.001 -- missing cx lookup -- 10.1523/JNEUROSCI.5126-11.2012 Crossref 10.1523/JNEUROSCI.5126-11.2012 -- missing cx lookup -- 10.1038/nrn3085 Crossref 10.1038/nrn3085 -- missing cx lookup -- 10.1016/j.neuroimage.2004.07.051 Crossref 10.1016/j.neuroimage.2004.07.051 -- missing cx lookup -- 10.1523/JNEUROSCI.14-03-01856.1994 Crossref 10.1523/JNEUROSCI.14-03-01856.1994 -- missing cx lookup -- 10.1111/j.1749-6632.2000.tb06726.x Crossref 10.1111/j.1749-6632.2000.tb06726.x -- missing cx lookup -- 10.1038/nrn2614 Crossref 10.1038/nrn2614 -- missing cx lookup -- 10.1089/brain.2012.0073 Crossref 10.1089/brain.2012.0073 -- missing cx lookup -- 10.1016/j.neuroimage.2012.03.023 Crossref 10.1016/j.neuroimage.2012.03.023 -- missing cx lookup -- 10.1016/j.bbr.2006.06.022 Crossref 10.1016/j.bbr.2006.06.022 -- missing cx lookup -- 10.1002/cne.903070308 Crossref 10.1002/cne.903070308 -- missing cx lookup -- 10.1098/rstb.2012.0515 Crossref 10.1098/rstb.2012.0515 -- missing cx lookup -- 10.1002/1098-1063(2000)10:4<398::AID-HIPO6>3.0.CO;2-K Crossref 10.1002/1098-1063(2000)10:4<398::AID-HIPO6>3.0.CO;2-K -- missing cx lookup -- 10.1111/j.1749-6632.2000.tb06716.x Crossref 10.1111/j.1749-6632.2000.tb06716.x -- missing cx lookup -- 10.1016/j.neuroimage.2008.09.016 Crossref 10.1016/j.neuroimage.2008.09.016 -- missing cx lookup -- 10.1002/ar.1061 Crossref 10.1002/ar.1061