138043 20240321220348.0 10.1016/j.neurobiolaging.2015.05.013 doi pmid:26170132 pmid 0197-4580 ISSN 1558-1497 ISSN altmetric:4278911 altmetric DZNE-2020-04365 English 610 Schmitz, Matthias P:(DE-2719)9000287 0 Cytokine profiles and the role of cellular prion protein in patients with vascular dementia and vascular encephalopathy. Amsterdam [u.a.] 2015 Elsevier Science print Crossref Elsevier BV 2015-09-01 article DRIVER Output Types/Journal article DataCite Journal Article journal journal PUB:(DE-HGF)16 1707925981_4694 PUB:(DE-HGF) ARTICLE BibTeX JOURNAL_ARTICLE ORCID Journal Article 0 EndNote Understanding inflammatory mechanisms in vascular dementia (VD) is pivotal for achieving better insights into changes in brain metabolism. We performed cytokine profiling and measured levels of the cellular prion protein (PrP(C)) in serum and cerebrospinal fluid (CSF) samples from patients with VD and with vascular encephalopathy (VE). Significant changes were observed for interleukin (IL)-1β, IL-4, IL-5, tumor necrosis factor alpha, interferon gamma, granulocyte-colony stimulating factor, monocyte chemotactic protein 1, and macrophage inflammatory protein 1 beta in serum and for IL-6 and granulocyte macrophage colony-stimulating factor in CSF of VD and VE patients, suggesting that most of immune markers depend on vascular lesions, while only IL-6 was related to dementia. In VD patients, the severity of dementia as defined by the Mini-Mental Status Test or Cambridge Cognitive Examination battery test was significantly correlated with the levels of IL-8 (CSF) and macrophage inflammatory protein 1 beta (serum and CSF). Additionally, in CSF of VD patients, our data revealed a correlation between immune and neurodegenerative marker proteins. Both indicate an association of neuroinflammation and cognitive decline. Levels of PrP(C) were regulated differentially in VD and VE patients compared with Alzheimer's disease patients and controls. Moreover, we observed a significant negative correlation between cytokine levels and PrP(C) in VD patients in CSF and serum, as well as a correlation between PrP(C) expression with levels of neurodegenerative marker proteins in CSF (in VD and VE patients). Our data suggest that immunological modifiers play a role in VD and VE patients and provide evidence for an association of PrP(C) with immune and neurodegenerative markers. 344 - Clinical and Health Care Research (POF3-344) G:(DE-HGF)POF3-344 POF3-344 POF III 0 2015-09-01 Crossref https://www.elsevier.com/tdm/userlicense/1.0/ Dataset connected to CrossRef, PubMed, Amyloid beta-Peptides NLM Chemicals Cytokines NLM Chemicals Peptide Fragments NLM Chemicals Prions NLM Chemicals amyloid beta-protein (1-40) NLM Chemicals amyloid beta-protein (1-42) NLM Chemicals tau Proteins NLM Chemicals Adult MeSH Aged MeSH Aged, 80 and over MeSH Amyloid beta-Peptides: cerebrospinal fluid MeSH Cerebrovascular Disorders: cerebrospinal fluid MeSH Cohort Studies MeSH Cytokines: cerebrospinal fluid MeSH Dementia, Vascular: cerebrospinal fluid MeSH Enzyme-Linked Immunosorbent Assay MeSH Female MeSH Humans MeSH Linear Models MeSH Male MeSH Mental Status Schedule MeSH Middle Aged MeSH Neuropsychological Tests MeSH Peptide Fragments: cerebrospinal fluid MeSH Prions: cerebrospinal fluid MeSH tau Proteins: cerebrospinal fluid MeSH Hermann, Peter P:(DE-2719)2812183 1 Oikonomou, Panteleimon P:(DE-2719)9000239 2 Stoeck, Katharina P:(DE-2719)9000304 3 Ebert, Elisabeth P:(DE-2719)9000063 4 Poliakova, Tatjana P:(DE-HGF)0 5 Schmidt, Christian P:(DE-2719)9000950 6 dzne Llorens, Franc P:(DE-2719)2811280 7 Zafar, Saima P:(DE-2719)9000358 8 Zerr, Inga P:(DE-2719)2000058 9 Last author 10.1016/j.neurobiolaging.2015.05.013 : Elsevier BV, 2015-09-01 9 2597-2606 journal-article Crossref Neurobiology of Aging 36 2015 0197-4580 10.1016/j.neurobiolaging.2015.05.013 Vol. 36, no. 9, p. 2597 - 2606 PERI:(DE-600)1498414-3 9 36:9<2597 - 2606 2597-2606 Neurobiology of aging 36 2015 0197-4580 http://pub.dzne.de/record/138043/files/DZNE-2020-04365_Restricted.pdf http://pub.dzne.de/record/138043/files/DZNE-2020-04365_Restricted.pdf?subformat=pdfa pdfa VDB oai:pub.dzne.de:138043 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 0 P:(DE-2719)9000287 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 1 P:(DE-2719)2812183 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 2 P:(DE-2719)9000239 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 3 P:(DE-2719)9000304 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 4 P:(DE-2719)9000063 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 6 P:(DE-2719)9000950 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 7 P:(DE-2719)2811280 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 8 P:(DE-2719)9000358 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 9 P:(DE-2719)2000058 DE-HGF Gesundheit Erkrankungen des Nervensystems G:(DE-HGF)POF3-340 G:(DE-HGF)POF3-344 G:(DE-HGF)POF3 G:(DE-HGF)POF3-300 G:(DE-HGF)POF Clinical and Health Care Research 0 2015 Nationallizenz StatID:(DE-HGF)0420 StatID DBCoverage StatID:(DE-HGF)0300 StatID Medline DBCoverage StatID:(DE-HGF)0310 StatID NCBI Molecular Biology Database JCR StatID:(DE-HGF)0100 StatID NEUROBIOL AGING : 2017 DBCoverage StatID:(DE-HGF)0200 StatID SCOPUS DBCoverage StatID:(DE-HGF)0600 StatID Ebsco Academic Search Peer Review StatID:(DE-HGF)0030 StatID ASC DBCoverage StatID:(DE-HGF)0199 StatID Clarivate Analytics Master Journal List WoS StatID:(DE-HGF)0110 StatID Science Citation Index DBCoverage StatID:(DE-HGF)0150 StatID Web of Science Core Collection WoS StatID:(DE-HGF)0111 StatID Science Citation Index Expanded DBCoverage StatID:(DE-HGF)1030 StatID Current Contents - Life Sciences DBCoverage StatID:(DE-HGF)1050 StatID BIOSIS Previews IF < 5 StatID:(DE-HGF)9900 StatID I:(DE-2719)1440011-1 AG Zerr Translational Studies and Biomarker 0 I:(DE-2719)5000037 Ext UMG Zerr Ext UMG Zerr 1 journal VDB I:(DE-2719)1440011-1 I:(DE-2719)5000037 UNRESTRICTED