138297 20240321220417.0 10.1038/nn.4194 doi pmid:26656643 pmid 1097-6256 ISSN 1471-003X ISSN 1471-0048 ISSN 1546-1726 ISSN altmetric:4875359 altmetric DZNE-2020-04619 English 570 Halder, Rashi P:(DE-2719)2810512 0 First author DNA methylation changes in plasticity genes accompany the formation and maintenance of memory. London 2016 Nature Publ. Group58142 online Crossref Springer Science and Business Media LLC 2015-12-14 print Crossref Springer Science and Business Media LLC 2016-01-01 article DRIVER Output Types/Journal article DataCite Journal Article journal journal PUB:(DE-HGF)16 1709307856_5353 PUB:(DE-HGF) ARTICLE BibTeX JOURNAL_ARTICLE ORCID Journal Article 0 EndNote The ability to form memories is a prerequisite for an organism's behavioral adaptation to environmental changes. At the molecular level, the acquisition and maintenance of memory requires changes in chromatin modifications. In an effort to unravel the epigenetic network underlying both short- and long-term memory, we examined chromatin modification changes in two distinct mouse brain regions, two cell types and three time points before and after contextual learning. We found that histone modifications predominantly changed during memory acquisition and correlated surprisingly little with changes in gene expression. Although long-lasting changes were almost exclusive to neurons, learning-related histone modification and DNA methylation changes also occurred in non-neuronal cell types, suggesting a functional role for non-neuronal cells in epigenetic learning. Finally, our data provide evidence for a molecular framework of memory acquisition and maintenance, wherein DNA methylation could alter the expression and splicing of genes involved in functional plasticity and synaptic wiring. 342 - Disease Mechanisms and Model Systems (POF3-342) G:(DE-HGF)POF3-342 POF3-342 POF III 0 2015-12-14 Crossref http://www.springer.com/tdm Dataset connected to CrossRef, PubMed, Chromatin NLM Chemicals Histones NLM Chemicals Animals MeSH Behavior, Animal: physiology MeSH CA1 Region, Hippocampal: metabolism MeSH Chromatin: chemistry MeSH Conditioning, Psychological MeSH DNA Methylation: genetics MeSH DNA Methylation: physiology MeSH Epigenesis, Genetic: genetics MeSH Epigenesis, Genetic: physiology MeSH Fear MeSH Gene Expression: genetics MeSH Gene Expression: physiology MeSH Gyrus Cinguli: metabolism MeSH Histones: metabolism MeSH Male MeSH Memory, Long-Term: physiology MeSH Memory, Short-Term: physiology MeSH Mice MeSH Mice, Inbred C57BL MeSH Neuronal Plasticity: genetics MeSH Neuronal Plasticity: physiology MeSH Hennion, Magali P:(DE-2719)2810666 1 Vidal, Ramon O P:(DE-2719)9000325 2 Shomroni, Orr P:(DE-2719)2810755 3 Rahman, Raza-Ur P:(DE-2719)2811127 4 Rajput, Ashish P:(DE-2719)2811012 5 Pena Centeno, Tonatiuh P:(DE-2719)2811063 6 dzne van Bebber, Frauke P:(DE-2719)9000319 7 Capece, Vincenzo P:(DE-2719)2810626 8 Garcia Vizcaino, Julio C P:(DE-2719)2810949 9 Schütz, Anna-Lena P:(DE-2719)2810585 10 Burkhardt, Susanne P:(DE-2719)2810773 11 Benito, Eva P:(DE-2719)2810482 12 Navarro-Sala, Magdalena P:(DE-2719)9000229 13 Javan, Sanaz Bahari P:(DE-2719)9000144 14 Haass, Christian P:(DE-2719)2202037 15 Schmid, Bettina P:(DE-2719)2241638 16 Fischer, Andre P:(DE-2719)2000047 17 Corresponding author Bonn, Stefan P:(DE-2719)2810547 18 Last author 10.1038/nn.4194 : Springer Science and Business Media LLC, 2015-12-14 1 102-110 journal-article Crossref Nature Neuroscience 19 2015 1097-6256 10.1038/nn.4194 Vol. 19, no. 1, p. 102 - 110 PERI:(DE-600)2028902-9 1 19:1<102 - 110 102-110 Nature reviews / Neuroscience 19 2016 1097-6256 VDB oai:pub.dzne.de:138297 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 0 P:(DE-2719)2810512 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 1 P:(DE-2719)2810666 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 2 P:(DE-2719)9000325 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 3 P:(DE-2719)2810755 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 4 P:(DE-2719)2811127 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 5 P:(DE-2719)2811012 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 6 P:(DE-2719)2811063 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 7 P:(DE-2719)9000319 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 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I:(DE-588)1065079516 DZNE 18 P:(DE-2719)2810547 DE-HGF Gesundheit Erkrankungen des Nervensystems G:(DE-HGF)POF3-340 G:(DE-HGF)POF3-342 G:(DE-HGF)POF3 G:(DE-HGF)POF3-300 G:(DE-HGF)POF Disease Mechanisms and Model Systems 0 2016 Nationallizenz StatID:(DE-HGF)0420 StatID JCR StatID:(DE-HGF)0100 StatID NAT REV NEUROSCI : 2017 DBCoverage StatID:(DE-HGF)0200 StatID SCOPUS DBCoverage StatID:(DE-HGF)0300 StatID Medline DBCoverage StatID:(DE-HGF)0310 StatID NCBI Molecular Biology Database DBCoverage StatID:(DE-HGF)0600 StatID Ebsco Academic Search Peer Review StatID:(DE-HGF)0030 StatID ASC DBCoverage StatID:(DE-HGF)0199 StatID Clarivate Analytics Master Journal List WoS StatID:(DE-HGF)0110 StatID Science Citation Index DBCoverage StatID:(DE-HGF)0150 StatID Web of Science Core Collection WoS StatID:(DE-HGF)0111 StatID Science Citation Index Expanded DBCoverage StatID:(DE-HGF)1030 StatID Current Contents - Life Sciences DBCoverage StatID:(DE-HGF)1050 StatID BIOSIS Previews DBCoverage 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