138393 20240826140117.0 10.1002/ana.24545 doi pmid:26505629 pmid 0364-5134 ISSN 1531-8249 ISSN altmetric:4680521 altmetric DZNE-2020-04715 English 610 Castillo-Gomez, Esther 0 The brain as immunoprecipitator of serum autoantibodies against N-Methyl-D-aspartate receptor subunit NR1. Hoboken, NJ 2016 Wiley-Blackwell online Crossref Wiley 2015-12-02 print Crossref Wiley 2016-01-01 article DRIVER Output Types/Journal article DataCite Journal Article journal journal PUB:(DE-HGF)16 1724673655_18923 PUB:(DE-HGF) ARTICLE BibTeX JOURNAL_ARTICLE ORCID Journal Article 0 EndNote Autoantibodies (AB) against N-methyl-D-aspartate receptor subunit NR1 (NMDAR1) are highly seroprevalent in health and disease. Symptomatic relevance may arise upon compromised blood-brain barrier (BBB). However, it remained unknown whether circulating NMDAR1 AB appear in the cerebrospinal fluid (CSF). Of n = 271 subjects with CSF-serum pairs, 26 were NMDAR1 AB seropositive, but only 1 was CSF positive. Contrariwise, tetanus AB (non-brain-binding) were present in serum and CSF of all subjects, with CSF levels higher upon BBB dysfunction. Translational mouse experiments proved the hypothesis that the brain acts as an 'immunoprecipitator'; simultaneous injection of NMDAR1 AB and the non-brain-binding green fluorescent protein AB resulted in high detectability of the former in brain and the latter in CSF. 344 - Clinical and Health Care Research (POF3-344) G:(DE-HGF)POF3-344 POF3-344 POF III 0 2015-09-01 Crossref http://doi.wiley.com/10.1002/tdm_license_1.1 Dataset connected to CrossRef, PubMed, Autoantibodies NLM Chemicals NR1 NMDA receptor NLM Chemicals Receptors, N-Methyl-D-Aspartate NLM Chemicals Adult MeSH Animals MeSH Autoantibodies: blood MeSH Autoantibodies: cerebrospinal fluid MeSH Blood-Brain Barrier: physiopathology MeSH Brain: immunology MeSH Female MeSH Humans MeSH Male MeSH Mice MeSH Mice, Inbred C57BL MeSH Middle Aged MeSH Multiple Sclerosis: blood MeSH Multiple Sclerosis: cerebrospinal fluid MeSH Receptors, N-Methyl-D-Aspartate: immunology MeSH Seroepidemiologic Studies MeSH Kästner, Anne 1 Steiner, Johann 2 Schneider, Anja P:(DE-2719)2812035 3 dzne Hettling, Bilke 4 Poggi, Giulia 5 Ostehr, Kristin 6 Uhr, Manfred 7 Asif, Abdul R 8 Matzke, Mike 9 Schmidt, Ulrike 10 Pfander, Viktoria 11 Hammer, Christian 12 Schulz, Thomas F 13 Binder, Lutz 14 Stöcker, Winfried 15 Weber, Frank 16 Ehrenreich, Hannelore P:(DE-HGF)0 17 Corresponding author 10.1002/ana.24545 : Wiley, 2015-12-02 1 144-151 journal-article Crossref Annals of Neurology 79 2015 0364-5134 10.1002/ana.24545 Vol. 79, no. 1, p. 144 - 151 PERI:(DE-600)2037912-2 1 79:1<144 - 151 144-151 Annals of neurology 79 2016 0364-5134 VDB oai:pub.dzne.de:138393 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 3 P:(DE-2719)2812035 DE-HGF Gesundheit Erkrankungen des Nervensystems G:(DE-HGF)POF3-340 G:(DE-HGF)POF3-344 G:(DE-HGF)POF3 G:(DE-HGF)POF3-300 G:(DE-HGF)POF Clinical and Health Care Research 0 2016 Nationallizenz StatID:(DE-HGF)0420 StatID DBCoverage StatID:(DE-HGF)0200 StatID SCOPUS DBCoverage StatID:(DE-HGF)0300 StatID Medline DBCoverage StatID:(DE-HGF)0310 StatID NCBI Molecular Biology Database JCR StatID:(DE-HGF)0100 StatID ANN NEUROL : 2017 DBCoverage StatID:(DE-HGF)0199 StatID Clarivate Analytics Master Journal List WoS StatID:(DE-HGF)0110 StatID Science Citation Index DBCoverage StatID:(DE-HGF)0150 StatID Web of Science Core Collection WoS StatID:(DE-HGF)0111 StatID Science Citation Index Expanded DBCoverage StatID:(DE-HGF)1110 StatID Current Contents - Clinical Medicine DBCoverage StatID:(DE-HGF)1030 StatID Current Contents - Life Sciences DBCoverage StatID:(DE-HGF)1050 StatID BIOSIS Previews IF >= 10 StatID:(DE-HGF)9910 StatID ANN NEUROL : 2017 I:(DE-2719)1440011 AG Schneider Göttingen Translational Dementia Research Göttingen 0 journal VDB I:(DE-2719)1440011 UNRESTRICTED -- missing cx lookup -- 10.1002/ana.24189 Crossref 10.1002/ana.24189 -- missing cx lookup -- 10.1038/mp.2013.110 Crossref 10.1038/mp.2013.110 -- missing cx lookup -- 10.1038/mp.2014.52 Crossref 10.1038/mp.2014.52 -- missing cx lookup -- 10.1016/S0022-510X(00)00501-3 Crossref 10.1016/S0022-510X(00)00501-3 -- missing cx lookup -- 10.1016/S1474-4422(08)70224-2 Crossref 10.1016/S1474-4422(08)70224-2 -- missing cx lookup -- 10.1016/j.jneuroim.2010.09.012 Crossref 10.1016/j.jneuroim.2010.09.012 -- missing cx lookup -- 10.1073/pnas.89.10.4471 Crossref 10.1073/pnas.89.10.4471 -- missing cx lookup -- 10.1161/STROKEAHA.114.008323 Crossref 10.1161/STROKEAHA.114.008323 -- missing cx lookup -- 10.1002/cne.901660302 Crossref 10.1002/cne.901660302 -- missing cx lookup -- 10.1016/S0959-4388(00)00215-4 Crossref 10.1016/S0959-4388(00)00215-4 -- missing cx lookup -- 10.1038/nrn2911 Crossref 10.1038/nrn2911 -- missing cx lookup -- 10.1038/nrn3504 Crossref 10.1038/nrn3504 -- missing cx lookup -- 10.1016/j.neuron.2014.12.032 Crossref 10.1016/j.neuron.2014.12.032 -- missing cx lookup -- 10.1002/acn3.120 Crossref 10.1002/acn3.120 -- missing cx lookup -- 10.1016/S1474-4422(13)70282-5 Crossref 10.1016/S1474-4422(13)70282-5 -- missing cx lookup -- 10.1093/brain/awu310 Crossref 10.1093/brain/awu310