138469 20240321220435.0 10.1002/hipo.22502 doi pmid:26235141 pmid 1050-9631 ISSN 1098-1063 ISSN altmetric:4359814 altmetric DZNE-2020-04791 English 610 Craig, Michael P:(DE-HGF)0 0 Corresponding author Wakeful rest promotes the integration of spatial memories into accurate cognitive maps. New York, NY [u.a.] 2016 Wiley online Crossref Wiley 2015-10-01 print Crossref Wiley 2016-02-01 article DRIVER Output Types/Journal article DataCite Journal Article journal journal PUB:(DE-HGF)16 1702373961_1338 PUB:(DE-HGF) ARTICLE BibTeX JOURNAL_ARTICLE ORCID Journal Article 0 EndNote Flexible spatial navigation, e.g. the ability to take novel shortcuts, is contingent upon accurate mental representations of environments-cognitive maps. These cognitive maps critically depend on hippocampal place cells. In rodents, place cells replay recently travelled routes, especially during periods of behavioural inactivity (sleep/wakeful rest). This neural replay is hypothesised to promote not only the consolidation of specific experiences, but also their wider integration, e.g. into accurate cognitive maps. In humans, rest promotes the consolidation of specific experiences, but the effect of rest on the wider integration of memories remained unknown. In the present study, we examined the hypothesis that cognitive map formation is supported by rest-related integration of new spatial memories. We predicted that if wakeful rest supports cognitive map formation, then rest should enhance knowledge of overarching spatial relations that were never experienced directly during recent navigation. Forty young participants learned a route through a virtual environment before either resting wakefully or engaging in an unrelated perceptual task for 10 min. Participants in the wakeful rest condition performed more accurately in a delayed cognitive map test, requiring the pointing to landmarks from a range of locations. Importantly, the benefit of rest could not be explained by active rehearsal, but can be attributed to the promotion of consolidation-related activity. These findings (i) resonate with the demonstration of hippocampal replay in rodents, and (ii) provide the first evidence that wakeful rest can improve the integration of new spatial memories in humans, a function that has, hitherto, been associated with sleep. 344 - Clinical and Health Care Research (POF3-344) G:(DE-HGF)POF3-344 POF3-344 POF III 0 2015-09-01 Crossref http://doi.wiley.com/10.1002/tdm_license_1.1 Dataset connected to CrossRef, PubMed, Cognition: physiology MeSH Female MeSH Humans MeSH Male MeSH Photic Stimulation: methods MeSH Psychomotor Performance: physiology MeSH Reaction Time: physiology MeSH Rest: physiology MeSH Spatial Memory: physiology MeSH Spatial Navigation: physiology MeSH Wakefulness: physiology MeSH Young Adult MeSH Dewar, Michaela P:(DE-HGF)0 1 Harris, Mathew A P:(DE-HGF)0 2 Della Sala, Sergio P:(DE-HGF)0 3 Wolbers, Thomas P:(DE-2719)2810583 4 Last author 10.1002/hipo.22502 : Wiley, 2015-10-01 2 185-193 journal-article Crossref Hippocampus 26 2015 1050-9631 10.1002/hipo.22502 Vol. 26, no. 2, p. 185 - 193 PERI:(DE-600)1498049-6 2 26:2<185 - 193 185-193 Hippocampus 26 2016 1050-9631 http://pub.dzne.de/record/138469/files/DZNE-2020-04791_GreenOAExternal.pdf http://pub.dzne.de/record/138469/files/DZNE-2020-04791_Restricted.pdf http://pub.dzne.de/record/138469/files/DZNE-2020-04791_GreenOAExternal.pdf?subformat=pdfa pdfa http://pub.dzne.de/record/138469/files/DZNE-2020-04791_Restricted.pdf?subformat=pdfa pdfa VDB oai:pub.dzne.de:138469 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 4 P:(DE-2719)2810583 DE-HGF Gesundheit Erkrankungen des Nervensystems G:(DE-HGF)POF3-340 G:(DE-HGF)POF3-344 G:(DE-HGF)POF3 G:(DE-HGF)POF3-300 G:(DE-HGF)POF Clinical and Health Care Research 0 2016 Nationallizenz StatID:(DE-HGF)0420 StatID JCR StatID:(DE-HGF)0100 StatID HIPPOCAMPUS : 2017 DBCoverage StatID:(DE-HGF)0200 StatID SCOPUS DBCoverage StatID:(DE-HGF)0300 StatID Medline DBCoverage StatID:(DE-HGF)0310 StatID NCBI Molecular Biology Database DBCoverage StatID:(DE-HGF)0199 StatID Clarivate Analytics Master Journal List WoS StatID:(DE-HGF)0110 StatID Science Citation Index DBCoverage StatID:(DE-HGF)0150 StatID Web of Science Core Collection WoS StatID:(DE-HGF)0111 StatID Science Citation Index Expanded DBCoverage StatID:(DE-HGF)1030 StatID Current Contents - 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