138658 20240321220458.0 10.1111/ejn.13213 doi pmid:26900934 pmid 0953-816X ISSN 1460-9568 ISSN altmetric:5955284 altmetric DZNE-2020-04980 English 610 Melzer, Juliane P:(DE-2719)2810805 0 First author Nerve-racking - apoptotic and non-apoptotic roles of caspases in the nervous system of Drosophila. Oxford [u.a.] 2016 Blackwell online Crossref Wiley 2016-03-19 print Crossref Wiley 2016-07-01 article DRIVER Output Types/Journal article DataCite Journal Article journal journal PUB:(DE-HGF)16 1590677733_3940 PUB:(DE-HGF) Review Article ARTICLE BibTeX JOURNAL_ARTICLE ORCID Journal Article 0 EndNote Studies using Drosophila as a model system have contributed enormously to our knowledge of caspase function and regulation. Caspases are best known as central executioners of apoptosis but also control essential physiological processes in a non-apoptotic manner. The Drosophila genome codes for seven caspases and in this review we provide an overview of current knowledge about caspase function in the nervous system. Caspases regulate neuronal death at all developmental stages and in various neuronal populations. In contrast, non-apoptotic roles are less well understood. The development of new genetically encoded sensors for caspase activity provides unprecedented opportunities to study caspase function in the nervous system in more detail. In light of these new tools we discuss the potential of Drosophila as a model to discover new apoptotic and non-apoptotic neuronal roles of caspases. 341 - Molecular Signaling (POF3-341) G:(DE-HGF)POF3-341 POF3-341 POF III 0 2015-09-01 Crossref http://doi.wiley.com/10.1002/tdm_license_1.1 Dataset connected to CrossRef, PubMed, Drosophila Proteins NLM Chemicals Caspases EC 3.4.22.- NLM Chemicals Animals MeSH Apoptosis MeSH Caspases: genetics MeSH Caspases: metabolism MeSH Drosophila: genetics MeSH Drosophila: growth & development MeSH Drosophila: metabolism MeSH Drosophila Proteins: genetics MeSH Drosophila Proteins: metabolism MeSH Nervous System: metabolism MeSH Neurogenesis MeSH Brömer, Meike P:(DE-2719)2810307 1 Last author 10.1111/ejn.13213 : Wiley, 2016-03-19 1 1683-1690 journal-article Crossref European Journal of Neuroscience 44 2016 0953-816X 10.1111/ejn.13213 Vol. 44, no. 1, p. 1683 - 1690 PERI:(DE-600)2005178-5 1 44:1<1683 - 1690 1683-1690 European journal of neuroscience 44 2016 0953-816X VDB oai:pub.dzne.de:138658 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 0 P:(DE-2719)2810805 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 1 P:(DE-2719)2810307 DE-HGF Forschungsbereich Gesundheit Erkrankungen des Nervensystems G:(DE-HGF)POF3-340 G:(DE-HGF)POF3-341 G:(DE-HGF)POF3-300 Molecular Signaling 0 2016 Nationallizenz StatID:(DE-HGF)0420 StatID JCR StatID:(DE-HGF)0100 StatID EUR J NEUROSCI : 2017 DBCoverage StatID:(DE-HGF)0200 StatID SCOPUS DBCoverage StatID:(DE-HGF)0300 StatID Medline DBCoverage StatID:(DE-HGF)0310 StatID NCBI Molecular Biology Database DBCoverage StatID:(DE-HGF)0600 StatID Ebsco Academic Search Peer Review StatID:(DE-HGF)0030 StatID ASC DBCoverage StatID:(DE-HGF)0199 StatID Clarivate Analytics Master Journal List WoS StatID:(DE-HGF)0110 StatID Science Citation Index DBCoverage StatID:(DE-HGF)0150 StatID Web of Science Core Collection WoS StatID:(DE-HGF)0111 StatID Science Citation Index Expanded DBCoverage StatID:(DE-HGF)1030 StatID Current Contents - Life Sciences DBCoverage StatID:(DE-HGF)1050 StatID BIOSIS Previews IF < 5 StatID:(DE-HGF)9900 StatID I:(DE-2719)5000021 AG Brömer 1 Ubiquitin-mediated Processes in Neurodegenerative Diseases 0 journal VDB I:(DE-2719)5000021 UNRESTRICTED 10.1016/j.ydbio.2015.05.013 -- missing cx lookup -- Crossref 10.1016/j.ydbio.2015.05.013 10.1242/dev.02332 -- missing cx lookup -- Crossref 10.1242/dev.02332 10.1016/j.neuron.2006.04.027 -- missing cx lookup -- Crossref 10.1016/j.neuron.2006.04.027 10.1073/pnas.0806983105 -- missing cx lookup -- Crossref 10.1073/pnas.0806983105 10.1038/sj.cdd.4402155 -- missing cx lookup -- Crossref 10.1038/sj.cdd.4402155 10.1016/j.cell.2014.07.045 -- missing cx lookup -- Crossref 10.1016/j.cell.2014.07.045 1993 Crossref Brand 1993 10.1038/nature08890 -- missing cx lookup -- Crossref 10.1038/nature08890 10.1038/459927a -- missing cx lookup -- Crossref 10.1038/459927a 10.1016/j.devcel.2004.09.016 -- 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