138664 20240410133151.0 2192-5917 ISSN 10.1007/s00441-016-2406-x doi pmid:27115420 pmid 0044-3794 ISSN 0302-766X ISSN 0340-0336 ISSN 0373-031X ISSN 1432-0878 ISSN altmetric:7101566 altmetric 0340-0387 ISSN DZNE-2020-04986 English 610 Machado, Venissa P:(DE-HGF)0 0 Gdf-15 deficiency does not alter vulnerability of nigrostriatal dopaminergic system in MPTP-intoxicated mice. Heidelberg 2016 Springer online Crossref Springer Science and Business Media LLC 2016-04-26 print Crossref Springer Science and Business Media LLC 2016-08-01 article DRIVER Output Types/Journal article DataCite Journal Article journal journal PUB:(DE-HGF)16 1712748656_11350 PUB:(DE-HGF) ARTICLE BibTeX JOURNAL_ARTICLE ORCID Journal Article 0 EndNote Growth/differentiation factor-15 (Gdf-15) is a member of the transforming growth factor-β (Tgf-β) superfamily and has been shown to be a potent neurotrophic factor for midbrain dopaminergic (DAergic) neurons both in vitro and in vivo. Gdf-15 has also been shown to be involved in inflammatory processes. The aim of this study was to identify the role of endogenous Gdf-15 in the MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) mouse model of Parkinson's disease (PD) by comparing Gdf-15 (+/+) and Gdf-15 (-/-) mice. At 4 days and 14 days post-MPTP administration, both Gdf-15 (+/+) and Gdf-15 (-/-) mice showed a similar decline in DAergic neuron numbers and in striatal dopamine (DA) levels. This was followed by a comparable restorative phase at 90 days and 120 days, indicating that the absence of Gdf-15 does not affect the susceptibility or the recovery capacity of the nigrostriatal system after MPTP administration. The MPTP-induced microglial and astrocytic response was not significantly altered between the two genotypes. However, pro-inflammatory and anti-inflammatory cytokine profiling revealed the differential expression of markers in Gdf-15 (+/+) and Gdf-15 (-/-) mice after MPTP administration. Thus, the MPTP mouse model fails to uncover a major role of endogenous Gdf-15 in the protection of MPTP-lesioned nigrostriatal DAergic neurons, in contrast to its capacity to protect the 6-hydroxydopamine-intoxicated nigrostriatal system. 341 - Molecular Signaling (POF3-341) G:(DE-HGF)POF3-341 POF3-341 POF III 0 2016-04-26 Crossref http://www.springer.com/tdm Dataset connected to CrossRef, PubMed, Biomarkers NLM Chemicals Cytokines NLM Chemicals Gdf15 protein, mouse NLM Chemicals Growth Differentiation Factor 15 NLM Chemicals Inflammation Mediators NLM Chemicals RNA, Messenger NLM Chemicals 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 9P21XSP91P NLM Chemicals 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine: administration & dosage MeSH Animals MeSH Biomarkers: metabolism MeSH Cell Proliferation MeSH Cytokines: metabolism MeSH Dopaminergic Neurons: metabolism MeSH Growth Differentiation Factor 15: deficiency MeSH Growth Differentiation Factor 15: metabolism MeSH Inflammation Mediators: metabolism MeSH Mice MeSH Neostriatum: metabolism MeSH Neostriatum: pathology MeSH Neuroglia: metabolism MeSH RNA, Messenger: genetics MeSH RNA, Messenger: metabolism MeSH Substantia Nigra: metabolism MeSH Substantia Nigra: pathology MeSH Gilsbach, Ralf P:(DE-HGF)0 1 Das, Richa P:(DE-2719)2811341 2 dzne Schober, Andreas P:(DE-HGF)0 3 Bogatyreva, Lioudmila P:(DE-HGF)0 4 Hauschke, Dieter P:(DE-2719)9000119 5 dzne Krieglstein, Kerstin P:(DE-HGF)0 6 Unsicker, Klaus P:(DE-HGF)0 7 Corresponding author Spittau, Björn P:(DE-HGF)0 8 10.1007/s00441-016-2406-x : Springer Science and Business Media LLC, 2016-04-26 2 209-223 journal-article Crossref Cell and Tissue Research 365 2016 0302-766X 10.1007/s00441-016-2406-x Vol. 365, no. 2, p. 209 - 223 PERI:(DE-600)1458496-7 2 365:2<209 - 223 209-223 Cell & tissue research 365 2016 0302-766X http://pub.dzne.de/record/138664/files/DZNE-2020-04986_Restricted.pdf http://pub.dzne.de/record/138664/files/DZNE-2020-04986_Restricted.pdf?subformat=pdfa pdfa VDB oai:pub.dzne.de:138664 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 2 P:(DE-2719)2811341 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 5 P:(DE-2719)9000119 DE-HGF Gesundheit Erkrankungen des Nervensystems G:(DE-HGF)POF3-340 G:(DE-HGF)POF3-341 G:(DE-HGF)POF3 G:(DE-HGF)POF3-300 G:(DE-HGF)POF Molecular Signaling 0 2016 Nationallizenz StatID:(DE-HGF)0420 StatID JCR StatID:(DE-HGF)0100 StatID CELL TISSUE RES : 2017 DBCoverage StatID:(DE-HGF)0200 StatID SCOPUS DBCoverage StatID:(DE-HGF)0300 StatID Medline DBCoverage StatID:(DE-HGF)0310 StatID NCBI Molecular Biology Database DBCoverage StatID:(DE-HGF)0600 StatID Ebsco Academic Search Peer Review StatID:(DE-HGF)0030 StatID ASC DBCoverage StatID:(DE-HGF)0199 StatID Clarivate Analytics Master Journal List WoS StatID:(DE-HGF)0110 StatID Science Citation Index DBCoverage StatID:(DE-HGF)0150 StatID Web of Science Core Collection WoS StatID:(DE-HGF)0111 StatID Science Citation Index 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