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@ARTICLE{Zimmer:138708,
      author       = {Zimmer, P. and Oberste, M. and Bloch, W. and Schenk, A. and
                      Joisten, N. and Hartig, P. and Wolf, F. and Baumann, F. T.
                      and Garthe, A. and Hallek, M. and Elter, T.},
      title        = {{I}mpact of aerobic exercise training during chemotherapy
                      on cancer related cognitive impairments in patients
                      suffering from acute myeloid leukemia or myelodysplastic
                      syndrome - {S}tudy protocol of a randomized
                      placebo-controlled trial.},
      journal      = {Contemporary clinical trials},
      volume       = {49},
      issn         = {1551-7144},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {DZNE-2020-05030},
      pages        = {1-5},
      year         = {2016},
      abstract     = {Cancer related cognitive impairments (CRCI) are frequently
                      reported by patients prior to, during and after medical
                      treatment. Although this cognitive decline severely affects
                      patients' quality of life, little is known about effective
                      treatments. Exercise programs represent a promising
                      supportive strategy in this field. However, evidence is
                      sparse and existing studies display methodological
                      limitations. In the planned study, 83 men and women newly
                      diagnosed with acute myeloid leukemia (AML) or
                      myelodysplastic syndrome (MDS) will be randomized into one
                      of three treatment groups. During 4weeks of induction
                      chemotherapy with Anthracycline and Cytarabin patients
                      allocated to exercise group will cycle 3×/week for 30min at
                      moderate to vigorous intensity on an ergometer. Patients
                      allocated to placebo group will receive a supervised
                      myofascial release training (3×/week, approx. 30min) and
                      patients at control group will get usual care. As primary
                      endpoints a cognitive test battery will be conducted
                      measuring performances depending on verbal/spatial memory
                      and executive functioning. Secondary endpoints will be
                      self-perceived cognitive functioning, as well as
                      neurotrophic and inflammatory serum markers. All assessments
                      will be conducted immediately after hospitalization and
                      before chemotherapy is commenced, immediately before
                      discharge of hospital after 4-5weeks as well as before
                      continuing medical treatment 3-4weeks after discharge. This
                      will be the first study investigating the impact of an
                      aerobic exercise training on CRCI in AML/MDS patients. We
                      hope that the study design and the state-of-the-art
                      assessments will help to increase knowledge about CRCI in
                      general and exercise as potential treatment option in this
                      under investigated population.},
      keywords     = {Anthracyclines: administration $\&$ dosage / Antineoplastic
                      Combined Chemotherapy Protocols: adverse effects / Bicycling
                      / Cognitive Dysfunction: etiology / Cognitive Dysfunction:
                      prevention $\&$ control / Cognitive Dysfunction: psychology
                      / Cognitive Dysfunction: rehabilitation / Cytarabine:
                      administration $\&$ dosage / Executive Function / Exercise
                      Therapy: methods / Humans / Leukemia, Myeloid, Acute:
                      complications / Leukemia, Myeloid, Acute: drug therapy /
                      Leukemia, Myeloid, Acute: psychology / Myelodysplastic
                      Syndromes: complications / Myelodysplastic Syndromes: drug
                      therapy / Myelodysplastic Syndromes: psychology /
                      Neuropsychological Tests / Spatial Memory / Treatment
                      Outcome / Anthracyclines (NLM Chemicals) / Cytarabine (NLM
                      Chemicals)},
      cin          = {AG Garthe},
      ddc          = {610},
      cid          = {I:(DE-2719)1740001},
      pnm          = {342 - Disease Mechanisms and Model Systems (POF3-342)},
      pid          = {G:(DE-HGF)POF3-342},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:27261170},
      doi          = {10.1016/j.cct.2016.05.007},
      url          = {https://pub.dzne.de/record/138708},
}