Journal Article

DZNE-2020-05244

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png In vivo Patterns of Tau Pathology, Amyloid-β Burden, and Neuronal Dysfunction in Clinical Variants of Alzheimer's Disease.

Dronse, J. (Corresponding author) ; Fliessbach, K.DZNE* ; Bischof, G. N. ; von Reutern, B. ; Faber, J.DZNE* ; Hammes, J. ; Kuhnert, G. ; Neumaier, B. ; Onur, O. A. ; Kukolja, J. ; Eimeren, T.DZNE* ; Jessen, F.DZNE* ; Fink, G. R. ; Klockgether, T.DZNE* ; Drzezga, A. (Last author)DZNE*

2017
IOS Press Amsterdam

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Please use a persistent id in citations: doi:10.3233/JAD-160316

Abstract: The clinical heterogeneity of Alzheimer's disease is not reflected in the rather diffuse cortical deposition of amyloid-β. We assessed the relationship between clinical symptoms, in vivo tau pathology, amyloid distribution, and hypometabolism in variants of Alzheimer's disease using novel multimodal PET imaging techniques. Tau pathology was primarily observed in brain regions related to clinical symptoms and overlapped with areas of hypometabolism. In contrast, amyloid-β deposition was diffusely distributed over the entire cortex. Tau PET imaging may thus serve as a valuable biomarker for the localization of neuronal injury in vivo and may help to validate atypical subtypes of Alzheimer's disease.

Keyword(s): Alzheimer Disease: complications (MeSH) ; Alzheimer Disease: diagnostic imaging (MeSH) ; Alzheimer Disease: pathology (MeSH) ; Amyloid beta-Peptides: metabolism (MeSH) ; Atrophy: etiology (MeSH) ; Brain: diagnostic imaging (MeSH) ; Brain: metabolism (MeSH) ; Brain: pathology (MeSH) ; Carbolines: metabolism (MeSH) ; Cognition Disorders: diagnostic imaging (MeSH) ; Cognition Disorders: etiology (MeSH) ; Corticomedial Nuclear Complex: pathology (MeSH) ; Executive Function (MeSH) ; Female (MeSH) ; Fluorodeoxyglucose F18: metabolism (MeSH) ; Humans (MeSH) ; Language Disorders: etiology (MeSH) ; Male (MeSH) ; Neuropsychological Tests (MeSH) ; Positron-Emission Tomography (MeSH) ; tau Proteins: metabolism (MeSH) ; Amyloid beta-Peptides ; Carbolines ; tau Proteins ; Fluorodeoxyglucose F18 ; 7-(6-fluoropyridin-3-yl)-5H-pyrido(4,3-b)indole

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Contributing Institute(s):

1. Clinical Alzheimer’s Disease Research (AG Jessen)
2. Positron Emissions Tomography (PET) (AG Boecker)

Research Program(s):

1. 344 - Clinical and Health Care Research (POF3-344) (POF3-344)

Appears in the scientific report 2017

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Database coverage:
; BIOSIS Previews ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; IF < 5 ; JCR ; SCOPUS ; Web of Science Core Collection

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