Journal Article

DZNE-2020-05470

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Left frontal cortex connectivity underlies cognitive reserve in prodromal Alzheimer disease.

Franzmeier, N. ; Duering, M. ; Weiner, M. ; Dichgans, M.DZNE* ; Ewers, M. (Corresponding author) ; Initiative, A. D. N.

2017
Ovid [S.l.]

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Please use a persistent id in citations: doi:10.1212/WNL.0000000000003711

Abstract: To test whether higher global functional connectivity of the left frontal cortex (LFC) in Alzheimer disease (AD) is associated with more years of education (a proxy of cognitive reserve [CR]) and mitigates the association between AD-related fluorodeoxyglucose (FDG)-PET hypometabolism and episodic memory.Forty-four amyloid-PET-positive patients with amnestic mild cognitive impairment (MCI-Aβ+) and 24 amyloid-PET-negative healthy controls (HC) were included. Voxel-based linear regression analyses were used to test the association between years of education and FDG-PET in MCI-Aβ+, controlled for episodic memory performance. Global LFC (gLFC) connectivity was computed through seed-based resting-state fMRI correlations between the LFC (seed) and each voxel in the gray matter. In linear regression analyses, education as a predictor of gLFC connectivity and the interaction of gLFC connectivity × FDG-PET hypometabolism on episodic memory were tested.FDG-PET metabolism in the precuneus was reduced in MCI-Aβ+ compared to HC (p = 0.028), with stronger reductions observed in MCI-Aβ+ with more years of education (p = 0.006). In MCI-Aβ+, higher gLFC connectivity was associated with more years of education (p = 0.021). At higher levels of gLFC connectivity, the association between precuneus FDG-PET hypometabolism and lower memory performance was attenuated (p = 0.027).Higher gLFC connectivity is a functional substrate of CR that helps to maintain episodic memory relatively well in the face of emerging FDG-PET hypometabolism in early-stage AD.

Keyword(s): Alzheimer Disease: complications (MeSH) ; Alzheimer Disease: diagnostic imaging (MeSH) ; Alzheimer Disease: pathology (MeSH) ; Chi-Square Distribution (MeSH) ; Cognition Disorders: etiology (MeSH) ; Cognitive Reserve: physiology (MeSH) ; Epilepsy: diagnostic imaging (MeSH) ; Epilepsy: etiology (MeSH) ; Female (MeSH) ; Fluorodeoxyglucose F18: metabolism (MeSH) ; Frontal Lobe: diagnostic imaging (MeSH) ; Frontal Lobe: pathology (MeSH) ; Functional Laterality: physiology (MeSH) ; Humans (MeSH) ; Magnetic Resonance Imaging (MeSH) ; Male (MeSH) ; Nerve Net: pathology (MeSH) ; Neuropsychological Tests (MeSH) ; Oxygen: blood (MeSH) ; Positron-Emission Tomography (MeSH) ; Prodromal Symptoms (MeSH) ; Fluorodeoxyglucose F18 ; Oxygen

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Contributing Institute(s):

1. Clinical Dementia Research München (Clinical Dementia Research München)

Research Program(s):

1. 344 - Clinical and Health Care Research (POF3-344) (POF3-344)

Appears in the scientific report 2017

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Database coverage:
; Allianz-Lizenz ; BIOSIS Previews ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; IF >= 10 ; JCR ; SCOPUS ; Web of Science Core Collection

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