139389 20240514120212.0 10.1038/s41598-017-06015-3 doi pmid:28720848 pmid pmc:PMC5515846 pmc altmetric:22185497 altmetric DZNE-2020-05711 English 600 Dittrich, Lars P:(DE-2719)2811120 0 First author dzne The natural Disc1-deletion present in several inbred mouse strains does not affect sleep. [London] 2017 Macmillan Publishers Limited, part of Springer Nature online Crossref Springer Science and Business Media LLC 2017-07-18 print Crossref Springer Science and Business Media LLC 2017-12-01 article DRIVER Output Types/Journal article DataCite Journal Article journal journal PUB:(DE-HGF)16 1715604081_2123 PUB:(DE-HGF) ARTICLE BibTeX JOURNAL_ARTICLE ORCID Journal Article 0 EndNote The gene Disrupted in Schizophrenia-1 (DISC1) is linked to a range of psychiatric disorders. Two recent transgenic studies suggest DISC1 is also involved in homeostatic sleep regulation. Several strains of inbred mice commonly used for genome manipulation experiments, including several Swiss and likely all 129 substrains, carry a natural deletion mutation of Disc1. This constitutes a potential confound for studying sleep in genetically modified mice. Since disturbed sleep can also influence psychiatric and neurodegenerative disease models, this putative confound might affect a wide range of studies in several fields. Therefore, we asked to what extent the natural Disc1 deletion affects sleep. To this end, we first compared sleep and electroencephalogram (EEG) phenotypes of 129S4 mice carrying the Disc1 deletion and C57BL/6N mice carrying the full-length version. We then bred Disc1 from C57BL/6N into the 129S4 background, resulting in S4-Disc1 mice. The differences between 129S4 and C57BL/6N were not detected in the 129S4 to S4-Disc1 comparison. We conclude that the mutation has no effect on the measured sleep and EEG characteristics. Thus, it is unlikely the widespread Disc1 deletion has led to spurious results in previous sleep studies or that it alters sleep in mouse models of psychiatric or neurodegenerative diseases. 899H - Addenda (POF3-899H) G:(DE-HGF)POF3-899H POF3-899H POF III 0 2017-07-18 Crossref http://creativecommons.org/licenses/by/4.0 Dataset connected to CrossRef, PubMed, Disc1 protein, mouse NLM Chemicals Nerve Tissue Proteins NLM Chemicals Animals MeSH Breeding MeSH Electroencephalography MeSH Female MeSH Male MeSH Mice MeSH Mice, Inbred C57BL MeSH Mice, Inbred Strains MeSH Nerve Tissue Proteins: genetics MeSH Sequence Deletion MeSH Sleep: genetics MeSH Sleep: physiology MeSH Petese, Alessandro P:(DE-2719)2811366 1 dzne Jackson, Walker S P:(DE-2719)2810253 2 Last author dzne 10.1038/s41598-017-06015-3 : Springer Science and Business Media LLC, 2017-07-18 1 5665 journal-article Crossref Scientific Reports 7 2017 2045-2322 10.1038/s41598-017-06015-3 Vol. 7, no. 1, p. 5665 PERI:(DE-600)2615211-3 1 7:1<5665 5665 Scientific reports 7 2017 2045-2322 OpenAccess http://pub.dzne.de/record/139389/files/DZNE-2020-05711.pdf OpenAccess pdfa http://pub.dzne.de/record/139389/files/DZNE-2020-05711.pdf?subformat=pdfa Pubmed Central http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5515846 oai:pub.dzne.de:139389 openaire open_access VDB driver dnbdelivery Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 0 P:(DE-2719)2811120 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 1 P:(DE-2719)2811366 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 2 P:(DE-2719)2810253 DE-HGF Programmungebundene Forschung ohne Programm G:(DE-HGF)POF3-890 G:(DE-HGF)POF3-899H G:(DE-HGF)POF3 G:(DE-HGF)POF3-800 G:(DE-HGF)POF Addenda 0 2017 DBCoverage StatID:(DE-HGF)0200 StatID SCOPUS 2023-03-30 Creative Commons Attribution CC BY (No Version) LIC:(DE-HGF)CCBYNV V:(DE-HGF) DOAJ DBCoverage StatID:(DE-HGF)1050 StatID BIOSIS Previews 2023-03-30 DBCoverage StatID:(DE-HGF)0600 StatID Ebsco Academic Search 2023-03-30 DBCoverage StatID:(DE-HGF)1040 StatID Zoological Record 2023-03-30 JCR StatID:(DE-HGF)0100 StatID SCI REP-UK : 2021 2023-03-30 DBCoverage StatID:(DE-HGF)0501 StatID DOAJ Seal 2022-08-08T09:38:07Z DBCoverage StatID:(DE-HGF)0500 StatID DOAJ 2022-08-08T09:38:07Z IF < 5 StatID:(DE-HGF)9900 StatID 2023-03-30 OpenAccess StatID:(DE-HGF)0510 StatID DBCoverage StatID:(DE-HGF)0150 StatID Web of Science Core Collection 2023-03-30 Peer Review StatID:(DE-HGF)0030 StatID ASC 2023-03-30 DBCoverage StatID:(DE-HGF)1150 StatID Current Contents - 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