139476 20240321220627.0 10.1016/j.neuron.2017.06.037 doi pmid:28858613 pmid pmc:PMC5659315 pmc 0896-6273 ISSN 1097-4199 ISSN altmetric:24533895 altmetric DZNE-2020-05798 English 610 Lester, Adam W 0 The Aging Navigational System. New York, NY 2017 Elsevier print Crossref Elsevier BV 2017-08-01 article DRIVER Output Types/Journal article DataCite Journal Article journal journal PUB:(DE-HGF)16 1710340148_30568 PUB:(DE-HGF) Review Article ARTICLE BibTeX JOURNAL_ARTICLE ORCID Journal Article 0 EndNote The discovery of neuronal systems dedicated to computing spatial information, composed of functionally distinct cell types such as place and grid cells, combined with an extensive body of human-based behavioral and neuroimaging research has provided us with a detailed understanding of the brain's navigation circuit. In this review, we discuss emerging evidence from rodents, non-human primates, and humans that demonstrates how cognitive aging affects the navigational computations supported by these systems. Critically, we show 1) that navigational deficits cannot solely be explained by general deficits in learning and memory, 2) that there is no uniform decline across different navigational computations, and 3) that navigational deficits might be sensitive markers for impending pathological decline. Following an introduction to the mechanisms underlying spatial navigation and how they relate to general processes of learning and memory, the review discusses how aging affects the perception and integration of spatial information, the creation and storage of memory traces for spatial information, and the use of spatial information during navigational behavior. The closing section highlights the clinical potential of behavioral and neural markers of spatial navigation, with a particular emphasis on neurodegenerative disorders. 344 - Clinical and Health Care Research (POF3-344) G:(DE-HGF)POF3-344 POF3-344 POF III 0 2017-08-01 Crossref https://www.elsevier.com/tdm/userlicense/1.0/ 2018-08-30 Crossref http://www.elsevier.com/open-access/userlicense/1.0/ Dataset connected to CrossRef, PubMed, Aging: physiology MeSH Animals MeSH Humans MeSH Learning: physiology MeSH Neurodegenerative Diseases: physiopathology MeSH Spatial Memory: physiology MeSH Spatial Navigation: physiology MeSH Spatial Processing: physiology MeSH Moffat, Scott D 1 Wiener, Jan M 2 Barnes, Carol A 3 Wolbers, Thomas P:(DE-2719)2810583 4 Last author dzne 10.1016/j.neuron.2017.06.037 : Elsevier BV, 2017-08-01 5 1019-1035 journal-article Crossref Neuron 95 2017 0896-6273 10.1016/j.neuron.2017.06.037 Vol. 95, no. 5, p. 1019 - 1035 PERI:(DE-600)2001944-0 5 95:5<1019 - 1035 1019-1035 Neuron 95 2017 0896-6273 Pubmed Central http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5659315 http://pub.dzne.de/record/139476/files/DZNE-2020-05798_Restricted.pdf http://pub.dzne.de/record/139476/files/DZNE-2020-05798_Restricted.pdf?subformat=pdfa pdfa VDB oai:pub.dzne.de:139476 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 4 P:(DE-2719)2810583 DE-HGF Gesundheit Erkrankungen des Nervensystems G:(DE-HGF)POF3-340 G:(DE-HGF)POF3-344 G:(DE-HGF)POF3 G:(DE-HGF)POF3-300 G:(DE-HGF)POF Clinical and Health Care Research 0 2017 Nationallizenz StatID:(DE-HGF)0420 StatID 2022-11-16 ger DBCoverage StatID:(DE-HGF)0300 StatID Medline 2022-11-16 DBCoverage StatID:(DE-HGF)0199 StatID Clarivate Analytics Master Journal List 2022-11-16 DBCoverage StatID:(DE-HGF)0150 StatID Web of Science Core Collection 2022-11-16 DBCoverage StatID:(DE-HGF)1050 StatID BIOSIS Previews 2022-11-16 DBCoverage StatID:(DE-HGF)1030 StatID Current Contents - Life Sciences 2022-11-16 JCR StatID:(DE-HGF)0100 StatID NEURON : 2021 2022-11-16 DBCoverage StatID:(DE-HGF)0200 StatID SCOPUS 2022-11-16 DBCoverage StatID:(DE-HGF)0600 StatID Ebsco Academic Search 2022-11-16 Peer Review StatID:(DE-HGF)0030 StatID ASC 2022-11-16 IF >= 15 StatID:(DE-HGF)9915 StatID NEURON : 2021 2022-11-16 I:(DE-2719)1310002 AG Wolbers Aging, Cognition and Technology 0 journal VDB I:(DE-2719)1310002 UNRESTRICTED