139722 20240826163725.0 10.15252/emmm.201707825 doi pmid:29208638 pmid pmc:PMC5760857 pmc 1715-4684 ISSN 1757-4676 ISSN 1757-4684 ISSN altmetric:30031306 altmetric DZNE-2020-06044 English 610 Martinez Hernandez, Ana P:(DE-2719)2810770 0 First author dzne The diphenylpyrazole compound anle138b blocks Aβ channels and rescues disease phenotypes in a mouse model for amyloid pathology. Heidelberg 2018 EMBO Press online Crossref EMBO 2017-12-05 print Crossref EMBO 2018-01-01 article DRIVER Output Types/Journal article DataCite Journal Article journal journal PUB:(DE-HGF)16 1724675292_22476 PUB:(DE-HGF) ARTICLE BibTeX JOURNAL_ARTICLE ORCID Journal Article 0 EndNote Alzheimer's disease is a devastating neurodegenerative disease eventually leading to dementia. An effective treatment does not yet exist. Here we show that oral application of the compound anle138b restores hippocampal synaptic and transcriptional plasticity as well as spatial memory in a mouse model for Alzheimer's disease, when given orally before or after the onset of pathology. At the mechanistic level, we provide evidence that anle138b blocks the activity of conducting Aβ pores without changing the membrane embedded Aβ-oligomer structure. In conclusion, our data suggest that anle138b is a novel and promising compound to treat AD-related pathology that should be investigated further. 342 - Disease Mechanisms and Model Systems (POF3-342) G:(DE-HGF)POF3-342 POF3-342 POF III 0 344 - Clinical and Health Care Research (POF3-344) G:(DE-HGF)POF3-344 POF3-344 POF III 1 2017-12-05 Crossref http://creativecommons.org/licenses/by/4.0/ 2017-12-05 Crossref http://doi.wiley.com/10.1002/tdm_license_1.1 Dataset connected to CrossRef, PubMed, 3-(1,3-benzodioxol-5-yl)-5-(3-bromophenyl)-1H-pyrazole NLM Chemicals Amyloid beta-Peptides NLM Chemicals Benzodioxoles NLM Chemicals Pyrazoles NLM Chemicals Alzheimer Disease: drug therapy MeSH Alzheimer Disease: genetics MeSH Alzheimer Disease: metabolism MeSH Alzheimer Disease: physiopathology MeSH Amyloid beta-Peptides: genetics MeSH Amyloid beta-Peptides: metabolism MeSH Animals MeSH Benzodioxoles: pharmacology MeSH Benzodioxoles: therapeutic use MeSH Disease Models, Animal MeSH Hippocampus: drug effects MeSH Hippocampus: metabolism MeSH Hippocampus: physiopathology MeSH Male MeSH Mice MeSH Mice, Inbred C57BL MeSH Neuronal Plasticity: drug effects MeSH Phenotype MeSH Pyrazoles: pharmacology MeSH Pyrazoles: therapeutic use MeSH Spatial Memory: drug effects MeSH Transcriptome: drug effects MeSH Urbanke, Hendrik P:(DE-2719)2811034 1 dzne Gillman, Alan L 2 Lee, Joon 3 Ryazanov, Sergey 4 Agbemenyah, Hope Y 5 Benito, Eva P:(DE-2719)2810482 6 dzne Jain, Gaurav P:(DE-2719)2811223 7 dzne Kaurani, Lalit 8 Grigorian, Gayane 9 Leonov, Andrei 10 Rezaei-Ghaleh, Nasrollah P:(DE-2719)9000418 11 dzne Wilken, Petra P:(DE-2719)2814028 12 dzne Arce, Fernando Teran 13 Wagner, Jens P:(DE-2719)2662292 14 dzne Fuhrmann, Martin P:(DE-2719)2679991 15 dzne Caruana, Mario 16 Camilleri, Angelique 17 Vassallo, Neville 18 Zweckstetter, Markus P:(DE-2719)2810591 19 dzne Benz, Roland 20 Giese, Armin P:(DE-HGF)0 21 Schneider, Anja P:(DE-2719)2812035 22 dzne Korte, Martin P:(DE-HGF)0 23 Corresponding author Lal, Ratnesh 24 Griesinger, Christian 25 Eichele, Gregor 26 Fischer, Andre P:(DE-2719)2000047 27 Last author dzne 10.15252/emmm.201707825 : EMBO, 2017-12-05 1 32-47 journal-article Crossref EMBO Molecular Medicine 10 2017 1757-4676 10.15252/emmm.201707825 Vol. 10, no. 1, p. 32 - 47 PERI:(DE-600)2485479-7 1 10:1<32 - 47 32-47 EMBO molecular medicine 10 2018 1757-4676 Pubmed Central http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760857 http://pub.dzne.de/record/139722/files/DZNE-2020-06044.pdf OpenAccess http://pub.dzne.de/record/139722/files/DZNE-2020-06044.pdf?subformat=pdfa pdfa OpenAccess oai:pub.dzne.de:139722 openaire open_access VDB driver dnbdelivery Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 0 P:(DE-2719)2810770 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 1 P:(DE-2719)2811034 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 6 P:(DE-2719)2810482 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 7 P:(DE-2719)2811223 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 11 P:(DE-2719)9000418 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 12 P:(DE-2719)2814028 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 14 P:(DE-2719)2662292 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 15 P:(DE-2719)2679991 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 19 P:(DE-2719)2810591 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 22 P:(DE-2719)2812035 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 27 P:(DE-2719)2000047 DE-HGF Gesundheit Erkrankungen des Nervensystems G:(DE-HGF)POF3-340 G:(DE-HGF)POF3-342 G:(DE-HGF)POF3 G:(DE-HGF)POF3-300 G:(DE-HGF)POF Disease Mechanisms and Model Systems 0 DE-HGF Gesundheit Erkrankungen des Nervensystems G:(DE-HGF)POF3-340 G:(DE-HGF)POF3-344 G:(DE-HGF)POF3 G:(DE-HGF)POF3-300 G:(DE-HGF)POF Clinical and Health Care Research 1 2018 DBCoverage StatID:(DE-HGF)0200 StatID SCOPUS 2022-11-29 DBCoverage StatID:(DE-HGF)1050 StatID BIOSIS Previews 2022-11-29 Creative Commons Attribution CC BY 4.0 LIC:(DE-HGF)CCBY4 HGFVOC JCR StatID:(DE-HGF)0100 StatID EMBO MOL MED : 2021 2022-11-29 DBCoverage StatID:(DE-HGF)0501 StatID DOAJ Seal 2021-07-19T13:19:31Z DBCoverage StatID:(DE-HGF)0500 StatID DOAJ 2021-07-19T13:19:31Z IF >= 10 StatID:(DE-HGF)9910 StatID EMBO MOL MED : 2021 2022-11-29 DBCoverage StatID:(DE-HGF)0150 StatID Web of Science Core Collection 2022-11-29 OpenAccess StatID:(DE-HGF)0510 StatID Peer Review StatID:(DE-HGF)0030 StatID DOAJ : Blind peer review, Double blind peer review 2021-07-19T13:19:31Z DBCoverage StatID:(DE-HGF)0300 StatID Medline 2022-11-29 DBCoverage StatID:(DE-HGF)0199 StatID Clarivate Analytics Master Journal List 2022-11-29 I:(DE-2719)1410002 AG Fischer ; 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