17 van Uem, Janet M T Cerff, Bernhard Kampmeyer, Malte Prinzen, Jos Zuidema, Menno Hobert, Markus A Gräber, Susanne Berg, Daniela Maetzler, Walter Liepelt-Scarfone, Inga Pre 2020 AG Maetzler AG Berg ; AG Berg Ext UKT Core ICRU AG Gasser Parkinsonism & related disorders Parkinsonism & related disorders Elsevier Science Amsterdam [u.a.] 1353-8020 10.1016/j.parkreldis.2017.12.023 English 74-81 48 Lower levels of physical activity are associated with lower Health-Related Quality of Life (HRQoL) in Parkinson's disease (PD). We evaluated the influence of quantitative physical activity parameters among other (disease-related) features representing other domains of the WHO International model for classification of Function, Disability, and Health (ICF) on HRQoL in PD.Home-based movement data (DynaPort MiniMod®) was collected in 47 PD patients. Nine stepwise regression models were calculated, with consecutive outcome variables: Parkinson's Disease Questionnaire (PDQ) Summary Index (SI), PDQ-Mobility, PDQ-Activities of Daily Living (ADL). Demographic variables, disease-specific features, and quantitative physical activity parameters, were included as predicting variables in all analyses. The following three physical activity parameters were alternately included for both sedentary and active episodes: 'percentage' of 24 h spent within these episodes, 'number of bouts', and 'mean bout lengths' (MBL).Depression and 'Total Energy Expenditure' were the main predictors of overall HRQoL (PDQ-SI), independent of the permutation of activity parameters. The same parameters predicted the PDQ-Mobility score. However, this result was altered when 'MBL' parameters were included into the model, 'MBL' of sedentary episodes additionally predicted HRQoL-Mobility. The PDQ-ADL score was associated with demographic, motor, and non-motor variables including cognitive status. After exclusion of demented PD patients, older age and cognitive impairment no longer constrained HRQoL-ADL.For the first time, we showed the influence of objective, home-based measured physical activity among depression and cognition on HRQoL in PD. This suggests that a multifactorial treatment approach would be most successful to increase HRQoL in PD. PUB:(DE-HGF)16, ; 0, ; Accelerometry Adult Aged Aged, 80 and over Cognition Disorders: etiology Cross-Sectional Studies Depression: etiology Exercise Female Humans Male Middle Aged Neuropsychological Tests Parkinson Disease: complications Parkinson Disease: psychology Psychiatric Status Rating Scales Quality of Life: psychology Severity of Illness Index Surveys and Questionnaires Journal Article 2018 DZNE-2020-06187 2018 pmid:29307560 https://pub.dzne.de/record/139865 https://doi.org/10.1016/j.parkreldis.2017.12.023