139865 20240321220711.0 10.1016/j.parkreldis.2017.12.023 doi pmid:29307560 pmid 1353-8020 ISSN 1873-5126 ISSN altmetric:31371415 altmetric DZNE-2020-06187 English 610 van Uem, Janet M T P:(DE-2719)9000322 0 First author dzne The association between objectively measured physical activity, depression, cognition, and health-related quality of life in Parkinson's disease. Amsterdam [u.a.] 2018 Elsevier Science print Crossref Elsevier BV 2018-03-01 article DRIVER Output Types/Journal article DataCite Journal Article journal journal PUB:(DE-HGF)16 1705935643_13660 PUB:(DE-HGF) ARTICLE BibTeX JOURNAL_ARTICLE ORCID Journal Article 0 EndNote Lower levels of physical activity are associated with lower Health-Related Quality of Life (HRQoL) in Parkinson's disease (PD). We evaluated the influence of quantitative physical activity parameters among other (disease-related) features representing other domains of the WHO International model for classification of Function, Disability, and Health (ICF) on HRQoL in PD.Home-based movement data (DynaPort MiniMod®) was collected in 47 PD patients. Nine stepwise regression models were calculated, with consecutive outcome variables: Parkinson's Disease Questionnaire (PDQ) Summary Index (SI), PDQ-Mobility, PDQ-Activities of Daily Living (ADL). Demographic variables, disease-specific features, and quantitative physical activity parameters, were included as predicting variables in all analyses. The following three physical activity parameters were alternately included for both sedentary and active episodes: 'percentage' of 24 h spent within these episodes, 'number of bouts', and 'mean bout lengths' (MBL).Depression and 'Total Energy Expenditure' were the main predictors of overall HRQoL (PDQ-SI), independent of the permutation of activity parameters. The same parameters predicted the PDQ-Mobility score. However, this result was altered when 'MBL' parameters were included into the model, 'MBL' of sedentary episodes additionally predicted HRQoL-Mobility. The PDQ-ADL score was associated with demographic, motor, and non-motor variables including cognitive status. After exclusion of demented PD patients, older age and cognitive impairment no longer constrained HRQoL-ADL.For the first time, we showed the influence of objective, home-based measured physical activity among depression and cognition on HRQoL in PD. This suggests that a multifactorial treatment approach would be most successful to increase HRQoL in PD. 344 - Clinical and Health Care Research (POF3-344) G:(DE-HGF)POF3-344 POF3-344 POF III 0 345 - Population Studies and Genetics (POF3-345) G:(DE-HGF)POF3-345 POF3-345 POF III 1 2018-03-01 Crossref https://www.elsevier.com/tdm/userlicense/1.0/ Dataset connected to CrossRef, PubMed, Accelerometry MeSH Adult MeSH Aged MeSH Aged, 80 and over MeSH Cognition Disorders: etiology MeSH Cross-Sectional Studies MeSH Depression: etiology MeSH Exercise MeSH Female MeSH Humans MeSH Male MeSH Middle Aged MeSH Neuropsychological Tests MeSH Parkinson Disease: complications MeSH Parkinson Disease: psychology MeSH Psychiatric Status Rating Scales MeSH Quality of Life: psychology MeSH Severity of Illness Index MeSH Surveys and Questionnaires MeSH Cerff, Bernhard P:(DE-2719)9000046 1 dzne Kampmeyer, Malte P:(DE-2719)9000147 2 dzne Prinzen, Jos P:(DE-HGF)0 3 Zuidema, Menno P:(DE-HGF)0 4 Hobert, Markus A P:(DE-2719)9000133 5 dzne Gräber, Susanne P:(DE-2719)2810662 6 dzne Berg, Daniela P:(DE-2719)2000059 7 dzne Maetzler, Walter P:(DE-2719)2810915 8 dzne Liepelt-Scarfone, Inga P:(DE-2719)2109499 9 Last author dzne 10.1016/j.parkreldis.2017.12.023 : Elsevier BV, 2018-03-01 74-81 journal-article Crossref Parkinsonism & Related Disorders 48 2018 1353-8020 10.1016/j.parkreldis.2017.12.023 Vol. 48, p. 74 - 81 PERI:(DE-600)2027635-7 48<74 - 81 74-81 Parkinsonism & related disorders 48 2018 1353-8020 http://pub.dzne.de/record/139865/files/DZNE-2020-06187_Restricted.pdf http://pub.dzne.de/record/139865/files/DZNE-2020-06187_Restricted.pdf?subformat=pdfa pdfa VDB oai:pub.dzne.de:139865 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 0 P:(DE-2719)9000322 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 1 P:(DE-2719)9000046 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 2 P:(DE-2719)9000147 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 5 P:(DE-2719)9000133 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 6 P:(DE-2719)2810662 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 7 P:(DE-2719)2000059 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 8 P:(DE-2719)2810915 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 9 P:(DE-2719)2109499 DE-HGF Gesundheit Erkrankungen des Nervensystems G:(DE-HGF)POF3-340 G:(DE-HGF)POF3-344 G:(DE-HGF)POF3 G:(DE-HGF)POF3-300 G:(DE-HGF)POF Clinical and Health Care Research 0 DE-HGF Gesundheit Erkrankungen des Nervensystems G:(DE-HGF)POF3-340 G:(DE-HGF)POF3-345 G:(DE-HGF)POF3 G:(DE-HGF)POF3-300 G:(DE-HGF)POF Population Studies and Genetics 1 2018 DBCoverage StatID:(DE-HGF)0300 StatID Medline 2022-11-12 DBCoverage StatID:(DE-HGF)0199 StatID Clarivate Analytics Master Journal List 2022-11-12 DBCoverage StatID:(DE-HGF)0150 StatID Web of Science Core Collection 2022-11-12 DBCoverage StatID:(DE-HGF)1110 StatID Current Contents - Clinical Medicine 2022-11-12 JCR StatID:(DE-HGF)0100 StatID PARKINSONISM RELAT D : 2021 2022-11-12 DBCoverage StatID:(DE-HGF)0200 StatID SCOPUS 2022-11-12 DBCoverage StatID:(DE-HGF)0600 StatID Ebsco Academic Search 2022-11-12 Peer Review StatID:(DE-HGF)0030 StatID ASC 2022-11-12 IF < 5 StatID:(DE-HGF)9900 StatID 2022-11-12 I:(DE-2719)999999 Pre 2020 DZNE before 2020 0 I:(DE-2719)5000024 AG Maetzler Functional Neurogeriatrics 1 I:(DE-2719)5000055 AG Berg ; AG Berg Parkinson's Disease Genetics 2 I:(DE-2719)5000058 Ext UKT Ext Universitätsklinikum Tübingen 3 I:(DE-2719)1240005 Core ICRU Core ICRU 4 I:(DE-2719)1210000 AG Gasser Parkinson Genetics 5 journal VDB I:(DE-2719)999999 I:(DE-2719)5000024 I:(DE-2719)5000055 I:(DE-2719)5000058 I:(DE-2719)1240005 I:(DE-2719)1210000 UNRESTRICTED