139887 20240321220713.0 10.1016/j.cub.2018.02.038 doi pmid:29551413 pmid pmc:PMC5887108 pmc 0960-9822 ISSN 1879-0445 ISSN altmetric:34374793 altmetric DZNE-2020-06209 English 570 Stangl, Matthias P:(DE-2719)2810620 0 First author dzne Compromised Grid-Cell-like Representations in Old Age as a Key Mechanism to Explain Age-Related Navigational Deficits. London 2018 Current Biology Ltd. print Crossref Elsevier BV 2018-04-01 article DRIVER Output Types/Journal article DataCite Journal Article journal journal PUB:(DE-HGF)16 1594197278_24853 PUB:(DE-HGF) ARTICLE BibTeX JOURNAL_ARTICLE ORCID Journal Article 0 EndNote A progressive loss of navigational abilities in old age has been observed in numerous studies, but we have only limited understanding of the neural mechanisms underlying this decline [1]. A central component of the brain's navigation circuit are grid cells in entorhinal cortex [2], largely thought to support intrinsic self-motion-related computations, such as path integration (i.e., keeping track of one's position by integrating self-motion cues) [3-6]. Given that entorhinal cortex is particularly vulnerable to neurodegenerative processes during aging and Alzheimer's disease [7-14], deficits in grid cell function could be a key mechanism to explain age-related navigational decline. To test this hypothesis, we conducted two experiments in healthy young and older adults. First, in an fMRI experiment, we found significantly reduced grid-cell-like representations in entorhinal cortex of older adults. Second, in a behavioral path integration experiment, older adults showed deficits in computations of self-position during path integration based on body-based or visual self-motion cues. Most strikingly, we found that these path integration deficits in older adults could be explained by their individual magnitudes of grid-cell-like representations, as reduced grid-cell-like representations were associated with larger path integration errors. Together, these results show that grid-cell-like representations in entorhinal cortex are compromised in healthy aging. Furthermore, the association between grid-cell-like representations and path integration performance in old age supports the notion that grid cells underlie path integration processes. We therefore conclude that impaired grid cell function may play a key role in age-related decline of specific higher-order cognitive functions, such as spatial navigation. 344 - Clinical and Health Care Research (POF3-344) G:(DE-HGF)POF3-344 POF3-344 POF III 0 2018-04-01 Crossref https://www.elsevier.com/tdm/userlicense/1.0/ 2018-02-20 Crossref http://creativecommons.org/licenses/by/4.0/ Dataset connected to CrossRef, PubMed, Adult MeSH Aged MeSH Aging: pathology MeSH Cognition: physiology MeSH Entorhinal Cortex: physiology MeSH Female MeSH Grid Cells: physiology MeSH Humans MeSH Male MeSH Spatial Memory: physiology MeSH Spatial Navigation: physiology MeSH Achtzehn, Johannes P:(DE-2719)2810753 1 dzne Huber, Karin P:(DE-2719)2811995 2 dzne Dietrich, Caroline P:(DE-2719)2811566 3 dzne Tempelmann, Claus P:(DE-HGF)0 4 Wolbers, Thomas P:(DE-2719)2810583 5 Last author dzne 10.1016/j.cub.2018.02.038 : Elsevier BV, 2018-04-01 7 1108-1115.e6 journal-article Crossref Current Biology 28 2018 0960-9822 10.1016/j.cub.2018.02.038 Vol. 28, no. 7, p. 1108 - 1115.e6 PERI:(DE-600)2019214-9 7 28:7<1108 - 1115.e6 1108-1115.e6 Current biology 28 2018 0960-9822 Pubmed Central http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5887108 oai:pub.dzne.de:139887 VDB Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 0 P:(DE-2719)2810620 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 1 P:(DE-2719)2810753 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 2 P:(DE-2719)2811995 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 3 P:(DE-2719)2811566 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 5 P:(DE-2719)2810583 DE-HGF Forschungsbereich Gesundheit Erkrankungen des Nervensystems G:(DE-HGF)POF3-340 G:(DE-HGF)POF3-344 G:(DE-HGF)POF3-300 Clinical and Health Care Research 0 2018 Nationallizenz StatID:(DE-HGF)0420 StatID 2022-11-22 ger JCR StatID:(DE-HGF)0100 StatID CURR BIOL : 2021 2022-11-22 DBCoverage StatID:(DE-HGF)0200 StatID SCOPUS 2022-11-22 DBCoverage StatID:(DE-HGF)0300 StatID Medline 2022-11-22 DBCoverage StatID:(DE-HGF)0600 StatID Ebsco Academic Search 2022-11-22 Peer Review StatID:(DE-HGF)0030 StatID ASC 2022-11-22 DBCoverage StatID:(DE-HGF)0199 StatID Clarivate Analytics Master Journal List 2022-11-22 DBCoverage StatID:(DE-HGF)0150 StatID Web of Science Core Collection 2022-11-22 DBCoverage StatID:(DE-HGF)1050 StatID BIOSIS Previews 2022-11-22 DBCoverage StatID:(DE-HGF)1030 StatID Current Contents - Life Sciences 2022-11-22 DBCoverage StatID:(DE-HGF)1040 StatID Zoological Record 2022-11-22 IF >= 10 StatID:(DE-HGF)9910 StatID CURR BIOL : 2021 2022-11-22 I:(DE-2719)1310002 AG Wolbers Aging & Cognition 0 journal VDB I:(DE-2719)1310002 UNRESTRICTED