TY  - JOUR
AU  - Lessard, Isabelle
AU  - Brais, Bernard
AU  - Côté, Isabelle
AU  - Lavoie, Caroline
AU  - Synofzik, Matthis
AU  - Mathieu, Jean
AU  - Gagnon, Cynthia
TI  - Assessing mobility and balance in Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay population: Validity and reliability of four outcome measures.
JO  - Journal of the neurological sciences
VL  - 390
SN  - 0022-510X
CY  - Amsterdam [u.a.]
PB  - Elsevier Science
M1  - DZNE-2020-06506
SP  - 4-9
PY  - 2018
AB  - To assess the construct validity of the 10-Meter Walk Test (10mWT), Six-Minute Walk Test (6MWT), Berg Balance Scale (BERG), and Timed Up and Go (TUG) in adults with Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay (ARSACS), in addition to the interrater reliability of the 10mWT and 6MWT.Reliability was determined using the intraclass correlation coefficient (ICC). Validity was determined first by correlating the 10mWT, 6MWT, BERG, and TUG with participant's age, lower limb coordination, and disease severity, and then by assessing their capacity to distinguish between participants based on sex and disease stages.Interrater reliability of the 10mWT at both comfortable and maximum speed as well as the 6MWT is excellent (ICC = 0.97-0.99). Construct validity of the four tests was confirmed, as showed by the high correlations with age, lower limb coordination, and overall disease severity (ρ = 0.64-0.97).The four tests assessed for their metrological properties in this study showed to be valid instruments to use in the ARSACS population. The 10mWT and 6MWT are also highly reliable. BERG and TUG reliability will need to be assess in a future study.
KW  - Adolescent
KW  - Adult
KW  - Biomechanical Phenomena
KW  - Disease Progression
KW  - Female
KW  - Humans
KW  - Male
KW  - Middle Aged
KW  - Movement
KW  - Muscle Spasticity: diagnosis
KW  - Muscle Spasticity: physiopathology
KW  - Muscle Spasticity: rehabilitation
KW  - Postural Balance
KW  - Reproducibility of Results
KW  - Severity of Illness Index
KW  - Sex Characteristics
KW  - Spinocerebellar Ataxias: congenital
KW  - Spinocerebellar Ataxias: diagnosis
KW  - Spinocerebellar Ataxias: physiopathology
KW  - Spinocerebellar Ataxias: rehabilitation
KW  - Walk Test: methods
KW  - Wheelchairs
KW  - Young Adult
LB  - PUB:(DE-HGF)16
C6  - pmid:29801904
DO  - DOI:10.1016/j.jns.2018.03.033
UR  - https://pub.dzne.de/record/140184
ER  -