engHöglinger, G. U.Respondek, G.Kovacs, G. G.New classification of tauopathies.info:eu-repo/classification/ddc/610HumansNeurodegenerative Diseases: classificationNeurodegenerative Diseases: geneticsSupranuclear Palsy, Progressive: classificationSupranuclear Palsy, Progressive: geneticsSupranuclear Palsy, Progressive: physiopathologyTauopathies: classificationTauopathies: geneticsTauopathies: physiopathologyTauopathies are a group of neurodegenerative diseases characterized by pathological intracellular deposits of the protein tau. Isoform composition, morphology and anatomical distribution of cellular tau-immunoreactivities are defining distinct tauopathies as molecular pathological disease entities. The clinical spectrum of tauopathies includes syndromes with primary motor symptoms and with primary cognitive dysfunction. The traditional syndrome-based classification is currently being complemented by a molecular-pathological classification. While the syndrome-based classification is helpful to select symptomatic therapies, and to generate clinical working hypotheses about underlying etiologies, the molecular-pathological classification is most important for the development and application of molecularly tailored disease-modifying therapies.Revue neurologique 174(9), 664-668 (2018). doi:10.1016/j.neurol.2018.07.001info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionElsevier Masson2018info:eu-repo/semantics/closedAccessDEhttps://pub.dzne.de/record/140284https://pub.dzne.de/search?p=id:%22DZNE-2020-06606%22Researchersinfo:eu-repo/semantics/altIdentifier/issn/0035-3787info:eu-repo/semantics/altIdentifier/doi/10.1016/j.neurol.2018.07.001info:eu-repo/semantics/altIdentifier/pmid/pmid:30098799info:eu-repo/semantics/altIdentifier/issn/2213-0004