17 Höglinger, G. U. Respondek, G. Kovacs, G. G. AG Höglinger 1 Revue neurologique Revue neurologique Elsevier Masson Issy-les-Moulineaux 0035-3787 10.1016/j.neurol.2018.07.001 English 664-668 9 174 Tauopathies are a group of neurodegenerative diseases characterized by pathological intracellular deposits of the protein tau. Isoform composition, morphology and anatomical distribution of cellular tau-immunoreactivities are defining distinct tauopathies as molecular pathological disease entities. The clinical spectrum of tauopathies includes syndromes with primary motor symptoms and with primary cognitive dysfunction. The traditional syndrome-based classification is currently being complemented by a molecular-pathological classification. While the syndrome-based classification is helpful to select symptomatic therapies, and to generate clinical working hypotheses about underlying etiologies, the molecular-pathological classification is most important for the development and application of molecularly tailored disease-modifying therapies. PUB:(DE-HGF)16, Review Article; 0, ; Humans Neurodegenerative Diseases: classification Neurodegenerative Diseases: genetics Supranuclear Palsy, Progressive: classification Supranuclear Palsy, Progressive: genetics Supranuclear Palsy, Progressive: physiopathology Tauopathies: classification Tauopathies: genetics Tauopathies: physiopathology Journal Article (Review Article) 2018 DZNE-2020-06606 2018 pmid:30098799 https://pub.dzne.de/record/140284 https://doi.org/10.1016/j.neurol.2018.07.001