140376 20240826135844.0 10.1212/WNL.0000000000006318 doi pmid:30209235 pmid 0028-3878 ISSN 1526-632X ISSN altmetric:48498238 altmetric DZNE-2020-06698 English 610 Steinacker, Petra 0 Serum neurofilament light chain in behavioral variant frontotemporal dementia. [S.l.] 2018 Ovid online Crossref Ovid Technologies (Wolters Kluwer Health) 2018-09-12 print Crossref Ovid Technologies (Wolters Kluwer Health) 2018-10-09 article DRIVER Output Types/Journal article DataCite Journal Article journal journal PUB:(DE-HGF)16 1724673498_30327 PUB:(DE-HGF) ARTICLE BibTeX JOURNAL_ARTICLE ORCID Journal Article 0 EndNote Objective: To determine the association of serum neurofilament light chain (NfL) with functional deterioration and brain atrophy during follow-up of patients with behavioral variant frontotemporal dementia (bvFTD).Methods: Blood NfL levels from 74 patients with bvFTD, 26 with Alzheimer disease (AD), 17 with mild cognitive impairment (MCI), and 15 healthy controls (Con) at baseline and follow-up were determined and analyzed for the diagnostic potential in relation to functional assessment (Clinical Dementia Rating Scale Sum of Boxes [CDR-SOB], frontotemporal lobar degeneration–related CDR-SOB, Mini-Mental State Examination [MMSE]) and brain volumetry.Results: At baseline, serum NfL level correlated with CSF NfL (bvFTD r = 0.706, p < 0.0001; AD/MCI r = 0.666, p = 0.0003). Highest serum levels were observed in bvFTD (p <0 0.0001 vs Con and MCI, p = 0.0078 vs AD, respectively). Discrimination of bvFTD from Con/MCI/AD was possible with 91%/74%/74% sensitivity and 79%/74%/58% specificity. At follow-up, serum NfL increased in bvFTD and AD (p = 0.0039 and p = 0.0006, respectively). At baseline and follow-up, NfL correlated with functional scores of patients with bvFTD (e.g., CDR-SOB [baseline] r = 0.4157, p = 0.0006; [follow-up] r = 0.5629, p < 0.0001) and with atrophy in the gray and white matter of many brain regions including frontal and subcortical areas (e.g., frontal lobe: r = −0.5857, p < 0.0001; 95% confidence interval −0.7415 to −0.3701). For patients with AD/MCI, NfL correlated with the functional performance as well (e.g., CDR-SOB [baseline] r = 0.6624, p < 0.0001; [follow-up] r = 0.5659, p = 0.0003) but not with regional brain volumes.Conclusions: As serum NfL correlates with functional impairment and brain atrophy in bvFTD at different disease stages, we propose it as marker of disease severity, paving the way for its future use as outcome measure for clinical trials.Classification of evidence: This study provides Class III evidence that for patients with cognitive problems, serum NfL concentration discriminates bvFTD from other forms of dementia. 344 - Clinical and Health Care Research (POF3-344) G:(DE-HGF)POF3-344 POF3-344 POF III 0 342 - Disease Mechanisms and Model Systems (POF3-342) G:(DE-HGF)POF3-342 POF3-342 POF III 1 Dataset connected to CrossRef, PubMed, Biomarkers NLM Chemicals Neurofilament Proteins NLM Chemicals neurofilament protein L NLM Chemicals Aged MeSH Alzheimer Disease: blood MeSH Alzheimer Disease: cerebrospinal fluid MeSH Alzheimer Disease: diagnostic imaging MeSH Alzheimer Disease: genetics MeSH Atrophy MeSH Biomarkers: blood MeSH Biomarkers: cerebrospinal fluid MeSH Brain: pathology MeSH Cognitive Dysfunction: blood MeSH Cognitive Dysfunction: cerebrospinal fluid MeSH Cognitive Dysfunction: diagnostic imaging MeSH Cognitive Dysfunction: genetics MeSH Diagnosis, Differential MeSH Disease Progression MeSH Female MeSH Follow-Up Studies MeSH Frontotemporal Dementia: blood MeSH Frontotemporal Dementia: diagnostic imaging MeSH Frontotemporal Dementia: genetics MeSH Frontotemporal Dementia: pathology MeSH Humans MeSH Male MeSH Middle Aged MeSH Mutation MeSH Neurofilament Proteins: blood MeSH Organ Size MeSH Prospective Studies MeSH Anderl-Straub, Sarah 1 Diehl-Schmid, Janine P:(DE-HGF)0 2 Semler, Elisa 3 Uttner, Ingo 4 von Arnim, Christine A F 5 Barthel, Henryk 6 Danek, Adrian P:(DE-HGF)0 7 Fassbender, Klaus 8 Fliessbach, Klaus P:(DE-HGF)0 9 Foerstl, Hans 10 Grimmer, Timo 11 Huppertz, Hans-Jürgen 12 Jahn, Holger 13 Kassubek, Jan 14 Kornhuber, Johannes 15 Landwehrmeyer, Bernhard 16 Lauer, Martin 17 Maler, Juan Manuel 18 Mayer, Benjamin 19 Oeckl, Patrick 20 Prudlo, Johannes P:(DE-2719)2380559 21 Schneider, Anja P:(DE-2719)2812035 22 dzne Volk, Alexander E 23 Wiltfang, Jens P:(DE-2719)2811317 24 Schroeter, Matthias L 25 Ludolph, Albert C P:(DE-HGF)0 26 Otto, Markus P:(DE-HGF)0 27 Corresponding author group, FTLDc study 28 Albrecht, Franziska 29 Bisenius, Sandrine 30 Feneberg, Emily 31 Haefner, Sibylle 32 Kasper, Elisabeth P:(DE-HGF)0 33 Kurzwelly, Delia P:(DE-HGF)0 34 Lampe, Leonie 35 Levin, Johannes P:(DE-HGF)0 36 Lornsen, Finn 37 Luley, Maxine 38 Oberstein, Timo 39 Pellkofer, Hannah 40 Prix, Catharina 41 Richter-Schmidinger, Tanja 42 Roth, Nina 43 Sabri, Osama 44 Schachner, Lisa 45 Schomburg, Robert 46 Schönecker, Sonja 47 Schuemberg, Katharina 48 Spottke, Annika P:(DE-HGF)0 49 Teipel, Stefan P:(DE-HGF)0 50 Wilken, Petra P:(DE-HGF)0 51 Zech, Heike 52 10.1212/wnl.0000000000006318 : Ovid Technologies (Wolters Kluwer Health), 2018-09-12 15 e1390-e1401 journal-article Crossref Neurology 91 2018 0028-3878 10.1212/WNL.0000000000006318 Vol. 91, no. 15, p. e1390 - e1401 PERI:(DE-600)1491874-2 15 91:15<e1390 - e1401 e1390-e1401 Neurology 91 2018 0028-3878 VDB oai:pub.dzne.de:140376 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 21 P:(DE-2719)2380559 External Institute I:(DE-HGF)0 Extern 22 P:(DE-2719)2812035 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 24 P:(DE-2719)2811317 DE-HGF Gesundheit Erkrankungen des Nervensystems G:(DE-HGF)POF3-340 G:(DE-HGF)POF3-344 G:(DE-HGF)POF3 G:(DE-HGF)POF3-300 G:(DE-HGF)POF Clinical and Health Care Research 0 DE-HGF Gesundheit Erkrankungen des Nervensystems G:(DE-HGF)POF3-340 G:(DE-HGF)POF3-342 G:(DE-HGF)POF3 G:(DE-HGF)POF3-300 G:(DE-HGF)POF Disease Mechanisms and Model Systems 1 2018 Allianz-Lizenz StatID:(DE-HGF)0410 StatID 2022-11-12 ger DBCoverage StatID:(DE-HGF)0300 StatID Medline 2022-11-12 DBCoverage StatID:(DE-HGF)0199 StatID Clarivate Analytics Master Journal List 2022-11-12 DBCoverage StatID:(DE-HGF)0150 StatID Web of Science Core Collection 2022-11-12 DBCoverage StatID:(DE-HGF)1050 StatID BIOSIS Previews 2022-11-12 DBCoverage StatID:(DE-HGF)1110 StatID Current Contents - Clinical Medicine 2022-11-12 DBCoverage StatID:(DE-HGF)1030 StatID Current Contents - Life Sciences 2022-11-12 JCR StatID:(DE-HGF)0100 StatID NEUROLOGY : 2021 2022-11-12 DBCoverage StatID:(DE-HGF)0200 StatID SCOPUS 2022-11-12 IF >= 10 StatID:(DE-HGF)9910 StatID NEUROLOGY : 2021 2022-11-12 I:(DE-2719)1510100 AG Teipel Clinical Dementia Research (Rostock /Greifswald) 0 I:(DE-2719)1410006 AG Wiltfang Molecular biomarkers for predictive diagnostics of neurodegenerative diseases 1 journal VDB I:(DE-2719)1510100 I:(DE-2719)1410006 UNRESTRICTED