140498 20240321220823.0 10.1080/00952990.2018.1557675 doi pmid:30632802 pmid 0095-2990 ISSN 1097-9891 ISSN DZNE-2020-06820 English 610 Schüller, Canan Beate 0 Neuronal correlates of delay discounting in healthy subjects and its implication for addiction: an ALE meta-analysis study. Abingdon 2019 Taylor & Francis Group online Crossref Informa UK Limited 2019-01-11 print Crossref Informa UK Limited 2019-01-02 article DRIVER Output Types/Journal article DataCite Journal Article journal journal PUB:(DE-HGF)16 1591102077_4415 PUB:(DE-HGF) Review Article ARTICLE BibTeX JOURNAL_ARTICLE ORCID Journal Article 0 EndNote Delay discounting (DD) describes the phenomenon of devaluing future rewards in favor of immediate rewards. Increased DD is a key behavioral marker of addiction, and has been suggested as a target for interventions to alleviate addiction symptoms (e.g., preference for immediate drug use over larger-and-later rewards, and relapses) in patients with substance use disorders (SUD).Performed a meta-analysis on neuroimaging results of DD regarding specific contrasts in healthy participants. Reviewed the results of existing patient studies in light of the meta-analyses results.We conducted activation likelihood estimation meta-analyses on DD neuroimaging studies (25 studies, n = 583; 354 males and 229 females) regarding six analytic strategies.The meta-analyses revealed various subdivisions of the cortical-basal ganglia circuits that are associated with different aspects of DD in healthy subjects. By comparing the meta-analyses results and patients' studies regarding each contrast, we highlighted three brain regions that may underlie excessive DD in patients. Decreased left inferior frontal gyrus (IFG) activity was related to less preference for delayed choices; reduced ventral striatum (VS) activity was associated with impaired valuation processes; and declined anterior cingulate cortex (ACC)/medial prefrontal cortex (mPFC) activity was associated with alterations in processing difficult choices.We propose that neuromodulation (e.g. deep brain simulation) or behavioral interventions (e.g. episodic future imagination) targeting these key brain regions (IFG, VS, ACC/mPFC) may be effective for improving DD function in patients with SUD, enhancing valuations of future rewards and helping to resist the temptation of immediate drug use. 344 - Clinical and Health Care Research (POF3-344) G:(DE-HGF)POF3-344 POF3-344 POF III 0 Dataset connected to CrossRef, PubMed, Brain: diagnostic imaging MeSH Choice Behavior: physiology MeSH Delay Discounting: physiology MeSH Female MeSH Healthy Volunteers MeSH Humans MeSH Male MeSH Neuroimaging: methods MeSH Reward MeSH Substance-Related Disorders: diagnostic imaging MeSH Kuhn, Jens 1 Jessen, Frank P:(DE-2719)2000032 2 dzne Hu, Xiaochen P:(DE-HGF)0 3 Corresponding author 10.1080/00952990.2018.1557675 : Informa UK Limited, 2019-01-02 1 51-66 journal-article Crossref The American Journal of Drug and Alcohol Abuse 45 2019 0095-2990 10.1080/00952990.2018.1557675 Vol. 45, no. 1, p. 51 - 66 PERI:(DE-600)2021266-5 1 45:1<51 - 66 51-66 The American journal of drug and alcohol abuse 45 2019 0095-2990 oai:pub.dzne.de:140498 VDB Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 2 P:(DE-2719)2000032 DE-HGF Forschungsbereich Gesundheit Erkrankungen des Nervensystems G:(DE-HGF)POF3-340 G:(DE-HGF)POF3-344 G:(DE-HGF)POF3-300 Clinical and Health Care Research 0 2019 Nationallizenz StatID:(DE-HGF)0420 StatID 2022-11-25 ger JCR StatID:(DE-HGF)0100 StatID AM J DRUG ALCOHOL AB : 2021 2022-11-25 DBCoverage StatID:(DE-HGF)0200 StatID SCOPUS 2022-11-25 DBCoverage StatID:(DE-HGF)0300 StatID Medline 2022-11-25 DBCoverage StatID:(DE-HGF)0600 StatID Ebsco Academic Search 2022-11-25 Peer Review StatID:(DE-HGF)0030 StatID ASC 2022-11-25 DBCoverage StatID:(DE-HGF)0199 StatID Clarivate Analytics Master Journal List 2022-11-25 DBCoverage StatID:(DE-HGF)1180 StatID Current Contents - Social and Behavioral Sciences 2022-11-25 DBCoverage StatID:(DE-HGF)0150 StatID Web of Science Core Collection 2022-11-25 DBCoverage StatID:(DE-HGF)1050 StatID BIOSIS Previews 2022-11-25 DBCoverage StatID:(DE-HGF)0130 StatID Social Sciences Citation Index 2022-11-25 IF < 5 StatID:(DE-HGF)9900 StatID 2022-11-25 I:(DE-2719)1011102 AG Jessen Patient studies cologne 0 journal VDB I:(DE-2719)1011102 UNRESTRICTED 10.1037/h0076860 -- missing cx lookup -- Crossref 10.1037/h0076860 10.1037/0022-3514.54.4.687 -- missing cx lookup -- Crossref 10.1037/0022-3514.54.4.687 10.1080/09652140020016978 -- missing cx lookup -- Crossref 10.1080/09652140020016978 10.1111/j.1467-9280.2005.01641.x -- missing cx lookup 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