140513 20240321220825.0 10.1016/j.neurobiolaging.2018.12.010 doi pmid:30703626 pmid 0197-4580 ISSN 1558-1497 ISSN altmetric:53570575 altmetric DZNE-2020-06835 English 610 Merhav, Maayan P:(DE-2719)2811087 0 First author dzne Spatial updating deficits in human aging are associated with traces of former memory representations. Amsterdam [u.a.] 2019 Elsevier Science print Crossref Elsevier BV 2019-04-01 article DRIVER Output Types/Journal article DataCite Journal Article journal journal PUB:(DE-HGF)16 1707493098_2405 PUB:(DE-HGF) ARTICLE BibTeX JOURNAL_ARTICLE ORCID Journal Article 0 EndNote The ability to update spatial memories is important for everyday situations, such as remembering where we left our keys or parked our car. Although rodent studies have suggested that old age might impair spatial updating, direct evidence for such a deficit in humans is missing. Here, we tested whether spatial updating deficits occur in human aging, whether the learning mode influences spatial updating, and what mnemonic mechanism underlies the presumed deficits. To address these questions, younger and older participants had to indicate the latest location of relocated items, following either incidental or intentional learning. Using eye tracking, we further quantified memory traces of the original and updated locations. We found that older participants were selectively impaired in recalling locations of relocated items. Furthermore, they depicted relatively stronger representations of the original locations, which were correlated with their spatial updating deficits. The findings demonstrate that stronger representations of former spatial contexts can impair spatial updating in aging, a mechanism that can help explain the commonly observed age-related decline in spatial memory. 344 - Clinical and Health Care Research (POF3-344) G:(DE-HGF)POF3-344 POF3-344 POF III 0 2019-04-01 Crossref https://www.elsevier.com/tdm/userlicense/1.0/ Dataset connected to CrossRef, PubMed, Adult MeSH Aged MeSH Aging: psychology MeSH Female MeSH Humans MeSH Learning: physiology MeSH Male MeSH Memory Disorders: psychology MeSH Mental Recall MeSH Proactive Inhibition MeSH Space Perception: physiology MeSH Spatial Memory: physiology MeSH Spatial Navigation: physiology MeSH Young Adult MeSH Riemer, Martin P:(DE-2719)2813753 1 dzne Wolbers, Thomas P:(DE-2719)2810583 2 Last author dzne 10.1016/j.neurobiolaging.2018.12.010 : Elsevier BV, 2019-04-01 53-61 journal-article Crossref Neurobiology of Aging 76 2019 0197-4580 10.1016/j.neurobiolaging.2018.12.010 Vol. 76, p. 53 - 61 PERI:(DE-600)1498414-3 76<53 - 61 53-61 Neurobiology of aging 76 2019 0197-4580 http://pub.dzne.de/record/140513/files/DZNE-2020-06835_Restricted.pdf http://pub.dzne.de/record/140513/files/DZNE-2020-06835_Restricted.pdf?subformat=pdfa pdfa VDB oai:pub.dzne.de:140513 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 0 P:(DE-2719)2811087 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 1 P:(DE-2719)2813753 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 2 P:(DE-2719)2810583 DE-HGF Gesundheit Erkrankungen des Nervensystems G:(DE-HGF)POF3-340 G:(DE-HGF)POF3-344 G:(DE-HGF)POF3 G:(DE-HGF)POF3-300 G:(DE-HGF)POF Clinical and Health Care Research 0 2019 Nationallizenz StatID:(DE-HGF)0420 StatID 2022-11-10 ger JCR StatID:(DE-HGF)0100 StatID NEUROBIOL AGING : 2021 2022-11-10 DBCoverage StatID:(DE-HGF)0200 StatID SCOPUS 2022-11-10 DBCoverage StatID:(DE-HGF)0300 StatID Medline 2022-11-10 DBCoverage StatID:(DE-HGF)0600 StatID Ebsco Academic Search 2022-11-10 Peer Review StatID:(DE-HGF)0030 StatID ASC 2022-11-10 DBCoverage StatID:(DE-HGF)0199 StatID Clarivate Analytics Master Journal List 2022-11-10 DBCoverage StatID:(DE-HGF)0150 StatID Web of Science Core Collection 2022-11-10 DBCoverage StatID:(DE-HGF)1050 StatID BIOSIS Previews 2022-11-10 DBCoverage StatID:(DE-HGF)1030 StatID Current Contents - Life Sciences 2022-11-10 IF >= 5 StatID:(DE-HGF)9905 StatID NEUROBIOL AGING : 2021 2022-11-10 I:(DE-2719)1310002 AG Wolbers Aging, Cognition and Technology 0 journal VDB I:(DE-2719)1310002 UNRESTRICTED