140637 20231218134222.0 10.1007/s00292-019-0580-9 doi pmid:30790012 pmid 0172-8113 ISSN 1432-1963 ISSN DZNE-2020-06959 ger 610 Pietsch, Torsten P:(DE-2719)2812617 0 First author dzne [Neuropathology of medulloblastomas and other CNS embryonal tumors : Precision diagnostics through the integration of genetic markers]. New York 2019 Springer online Crossref Springer Science and Business Media LLC 2019-02-21 print Crossref Springer Science and Business Media LLC 2019-03-01 article DRIVER Output Types/Journal article DataCite Journal Article journal journal PUB:(DE-HGF)16 1702903287_15630 PUB:(DE-HGF) ARTICLE BibTeX JOURNAL_ARTICLE ORCID Journal Article 0 EndNote The revised WHO classification of tumors of the central nervous system (CNS) in 2016 introduced the concept of the 'integrated diagnosis.' The definition of medulloblastoma entities now requires a combination of traditional histological information with additional molecular/genetic features. To define the histopathological component of the medulloblastoma diagnosis, tumors have to be assigned to one of the four histological entities: classic, desmoplastic/nodular (DNMB), extensive nodular (MBEN), or large cell/anaplastic (LC/A) medulloblastoma. The genetically defined component is one of the four entities: 'WNT activated', 'SHH activated and TP53 wildtype', 'SHH activated and TP53 mutant', or 'non-WNT/non-SHH medulloblastoma.' Robust and validated methods are available that allow a precise diagnosis of these medulloblastoma entities according to the updated WHO classification and for differential diagnostic purposes. An immunohistochemical analysis of protein markers including ß‑Catenin, Yap1, p75-NGFR, Otx2 and p53, in combination with targeted sequencing and chromosomal copy number assessment (such as FISH analysis for MYC genes), allows a precise stratification of patients for risk-adapted treatment. The group of other embryonic tumors of the central nervous system includes embryonic tumors with multilayered rosettes (ETMR), which frequently carry an amplification of the micro-RNA cluster C19MC and the (ganglio-)neuroblastomas of the CNS. These rare tumors can also be identified by characteristic genetic and immunophenotypic features. 345 - Population Studies and Genetics (POF3-345) G:(DE-HGF)POF3-345 POF3-345 POF III 0 2019-02-21 Crossref http://www.springer.com/tdm Dataset connected to CrossRef, PubMed, Genetic Markers NLM Chemicals Cerebellar Neoplasms MeSH Genetic Markers MeSH Humans MeSH Medulloblastoma MeSH Neoplasms, Germ Cell and Embryonal MeSH Neuropathology MeSH 10.1007/s00292-019-0580-9 : Springer Science and Business Media LLC, 2019-02-21 2 140-147 journal-article Crossref Der Pathologe 40 2019 0172-8113 10.1007/s00292-019-0580-9 Vol. 40, no. 2, p. 140 - 147 PERI:(DE-600)1462980-X 2 40:2<140 - 147 140-147 Der Pathologe 40 2019 0172-8113 http://pub.dzne.de/record/140637/files/DZNE-2020-06959_Restricted.pdf http://pub.dzne.de/record/140637/files/DZNE-2020-06959_Restricted.pdf?subformat=pdfa pdfa VDB oai:pub.dzne.de:140637 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 0 P:(DE-2719)2812617 DE-HGF Gesundheit Erkrankungen des Nervensystems G:(DE-HGF)POF3-340 G:(DE-HGF)POF3-345 G:(DE-HGF)POF3 G:(DE-HGF)POF3-300 G:(DE-HGF)POF Population Studies and Genetics 0 2019 Nationallizenz StatID:(DE-HGF)0420 StatID 2021-01-29 ger DBCoverage StatID:(DE-HGF)0200 StatID SCOPUS 2021-01-29 DBCoverage StatID:(DE-HGF)0300 StatID Medline 2021-01-29 DBCoverage StatID:(DE-HGF)0199 StatID Clarivate Analytics Master Journal List 2021-01-29 DBCoverage StatID:(DE-HGF)1030 StatID Current Contents - Life Sciences 2021-01-29 DBCoverage StatID:(DE-HGF)0150 StatID Web of Science Core Collection 2021-01-29 JCR StatID:(DE-HGF)0100 StatID PATHOLOGE : 2019 2021-01-29 IF < 5 StatID:(DE-HGF)9900 StatID 2021-01-29 I:(DE-2719)1011009 Brainbank Unit Bonn Brainbank Unit Bonn 0 journal VDB I:(DE-2719)1011009 UNRESTRICTED -- missing cx lookup -- 10.1038/nature26000 Crossref 10.1038/nature26000 -- missing cx lookup -- 10.1097/01.jnen.0000199576.70923.8a Crossref 10.1097/01.jnen.0000199576.70923.8a 2016 Crossref World Health Organization classification of tumors of the central nervous system CG Eberhart World Health Organization classification of tumors of the central nervous system 2016 2016 Crossref World Health Organization classification of tumours of the central nervous system DW Ellison World Health Organization classification of tumours of the central nervous system 2016 -- missing cx lookup -- 10.1200/JCO.2005.01.5479 Crossref 10.1200/JCO.2005.01.5479 -- missing cx lookup -- 10.1016/S1470-2045(18)30532-1 Crossref 10.1016/S1470-2045(18)30532-1 -- missing cx lookup -- 10.1111/nan.12161 Crossref 10.1111/nan.12161 -- missing cx lookup -- 10.1002/ijc.22675 Crossref 10.1002/ijc.22675 -- missing cx lookup -- 10.1002/ijc.1342 Crossref 10.1002/ijc.1342 -- missing cx lookup -- 10.1016/j.ccr.2014.02.004 Crossref 10.1016/j.ccr.2014.02.004 -- missing cx lookup -- 10.1007/s00401-013-1228-0 Crossref 10.1007/s00401-013-1228-0 -- missing cx lookup -- 10.1002/ijc.25508 Crossref 10.1002/ijc.25508 2016 Crossref WHO classification of tumours of the central nervous system DN Louis WHO classification of tumours of the central nervous system 2016 2016 Crossref World Health Organization classification of tumours of the central nervous system T Pietsch World Health Organization classification of tumours of the central nervous system 2016 -- missing cx lookup -- 10.5414/NP300999 Crossref 10.5414/NP300999 -- missing cx lookup -- 10.1007/s00401-014-1276-0 Crossref 10.1007/s00401-014-1276-0 1997 Crossref T Pietsch 1997 -- missing cx lookup -- 10.1200/JCO.2011.34.9373 Crossref 10.1200/JCO.2011.34.9373 -- missing cx lookup -- 10.1056/NEJMoa042176 Crossref 10.1056/NEJMoa042176 -- missing cx lookup -- 10.1215/15228517-2008-084 Crossref 10.1215/15228517-2008-084 -- missing cx lookup -- 10.1016/j.cell.2016.01.015 Crossref 10.1016/j.cell.2016.01.015 -- missing cx lookup -- 10.1200/JCO.2009.26.8169 Crossref 10.1200/JCO.2009.26.8169 -- missing cx lookup -- 10.1007/s00401-011-0922-z Crossref 10.1007/s00401-011-0922-z -- missing cx lookup -- 10.1186/gb-2007-8-11-r246 Crossref 10.1186/gb-2007-8-11-r246 -- missing cx lookup -- 10.1093/neuonc/now050 Crossref 10.1093/neuonc/now050 -- missing cx lookup -- 10.1200/JCO.2012.48.5052 Crossref 10.1200/JCO.2012.48.5052