140669 20250606100745.0 10.1002/ana.25460 doi pmid:30843274 pmid pmc:PMC6593665 pmc 0364-5134 ISSN 1531-8249 ISSN altmetric:56715664 altmetric DZNE-2020-06991 English 610 Wenke, Nina Kerstin P:(DE-2719)2811131 0 First author dzne N-methyl-D-aspartate receptor dysfunction by unmutated human antibodies against the NR1 subunit. Hoboken, NJ 2019 Wiley-Blackwell online Crossref Wiley 2019-04-02 print Crossref Wiley 2019-05-01 article DRIVER Output Types/Journal article DataCite Journal Article journal journal PUB:(DE-HGF)16 1749124421_15769 PUB:(DE-HGF) ARTICLE BibTeX JOURNAL_ARTICLE ORCID Journal Article 0 EndNote Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is the most common autoimmune encephalitis related to autoantibody-mediated synaptic dysfunction. Cerebrospinal fluid-derived human monoclonal NR1 autoantibodies showed low numbers of somatic hypermutations or were unmutated. These unexpected germline-configured antibodies showed weaker binding to the NMDAR than matured antibodies from the same patient. In primary hippocampal neurons, germline NR1 autoantibodies strongly and specifically reduced total and synaptic NMDAR currents in a dose- and time-dependent manner. The findings suggest that functional NMDAR antibodies are part of the human naïve B cell repertoire. Given their effects on synaptic function, they might contribute to a broad spectrum of neuropsychiatric symptoms. Ann Neurol 2019;85:771-776. 342 - Disease Mechanisms and Model Systems (POF3-342) G:(DE-HGF)POF3-342 POF3-342 POF III 0 341 - Molecular Signaling (POF3-341) G:(DE-HGF)POF3-341 POF3-341 POF III 1 2019-04-02 Crossref http://creativecommons.org/licenses/by-nc/4.0/ 2019-04-02 Crossref http://doi.wiley.com/10.1002/tdm_license_1.1 Dataset connected to CrossRef, PubMed, Animals MeSH Anti-N-Methyl-D-Aspartate Receptor Encephalitis: blood MeSH Anti-N-Methyl-D-Aspartate Receptor Encephalitis: pathology MeSH Autoantibodies: blood MeSH HEK293 Cells MeSH Hippocampus: chemistry MeSH Hippocampus: metabolism MeSH Hippocampus: pathology MeSH Humans MeSH Mice MeSH Neurons: chemistry MeSH Neurons: metabolism MeSH Protein Binding: physiology MeSH Protein Structure, Secondary MeSH Receptors, N-Methyl-D-Aspartate: blood MeSH Receptors, N-Methyl-D-Aspartate: chemistry MeSH Kreye, Jakob P:(DE-2719)2811468 1 dzne Andrzejak, Ewa P:(DE-2719)2811708 2 dzne Casteren, Adriana P:(DE-2719)2814218 3 dzne Leubner, Jonas P:(DE-2719)2811472 4 dzne Murgueitio, Manuela S P:(DE-HGF)0 5 Reincke, S Momsen P:(DE-2719)2812526 6 dzne Secker, Christopher P:(DE-2719)9000380 7 dzne Schmidl, Lars P:(DE-HGF)0 8 Geis, Christian P:(DE-HGF)0 9 Ackermann, Frauke P:(DE-2719)2810967 10 dzne Nikolaus, Marc P:(DE-HGF)0 11 Garner, Craig C P:(DE-2719)2810922 12 dzne Wardemann, Hedda P:(DE-HGF)0 13 Wolber, Gerhard P:(DE-HGF)0 14 Prüss, Harald P:(DE-2719)2810931 15 Last author dzne 10.1002/ana.25460 : Wiley, 2019-04-02 5 771-776 journal-article Crossref Annals of Neurology 85 2019 0364-5134 10.1002/ana.25460 Vol. 85, no. 5, p. 771 - 776 PERI:(DE-600)2037912-2 5 85:5<771 - 776 771-776 Annals of neurology 85 2019 0364-5134 Pubmed Central http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6593665 http://pub.dzne.de/record/140669/files/DZNE-2020-06991.pdf OpenAccess http://pub.dzne.de/record/140669/files/DZNE-2020-06991.pdf?subformat=pdfa pdfa OpenAccess oai:pub.dzne.de:140669 openaire open_access VDB driver dnbdelivery Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 0 P:(DE-2719)2811131 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 1 P:(DE-2719)2811468 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 2 P:(DE-2719)2811708 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 3 P:(DE-2719)2814218 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 4 P:(DE-2719)2811472 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 6 P:(DE-2719)2812526 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 7 P:(DE-2719)9000380 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 10 P:(DE-2719)2810967 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 12 P:(DE-2719)2810922 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 15 P:(DE-2719)2810931 DE-HGF Gesundheit Erkrankungen des Nervensystems G:(DE-HGF)POF3-340 G:(DE-HGF)POF3-342 G:(DE-HGF)POF3 G:(DE-HGF)POF3-300 G:(DE-HGF)POF Disease Mechanisms and Model Systems 0 DE-HGF Gesundheit Erkrankungen des Nervensystems G:(DE-HGF)POF3-340 G:(DE-HGF)POF3-341 G:(DE-HGF)POF3 G:(DE-HGF)POF3-300 G:(DE-HGF)POF Molecular Signaling 1 2019 DBCoverage StatID:(DE-HGF)0200 StatID SCOPUS 2022-11-30 Creative Commons Attribution-NonCommercial CC BY-NC 4.0 LIC:(DE-HGF)CCBYNC4 HGFVOC DBCoverage StatID:(DE-HGF)1050 StatID BIOSIS Previews 2022-11-30 DBCoverage StatID:(DE-HGF)0600 StatID Ebsco Academic Search 2022-11-30 JCR StatID:(DE-HGF)0100 StatID ANN NEUROL : 2021 2022-11-30 IF >= 10 StatID:(DE-HGF)9910 StatID ANN NEUROL : 2021 2022-11-30 DBCoverage StatID:(DE-HGF)0150 StatID Web of Science Core Collection 2022-11-30 DBCoverage StatID:(DE-HGF)1030 StatID Current Contents - Life Sciences 2022-11-30 OpenAccess StatID:(DE-HGF)0510 StatID Peer Review StatID:(DE-HGF)0030 StatID ASC 2022-11-30 DBCoverage StatID:(DE-HGF)0300 StatID Medline 2022-11-30 DBCoverage StatID:(DE-HGF)1110 StatID Current Contents - Clinical Medicine 2022-11-30 Nationallizenz StatID:(DE-HGF)0420 StatID 2022-11-30 ger DBCoverage StatID:(DE-HGF)0199 StatID Clarivate Analytics Master Journal List 2022-11-30 I:(DE-2719)1810003 AG Prüß Autoimmune Encephalopathies 0 I:(DE-2719)1810001 AG Garner Synaptopathy 1 I:(DE-2719)1813004 AG Ackermann Astrocyte - Synapse Interactions 2 journal VDB I:(DE-2719)1810003 I:(DE-2719)1810001 I:(DE-2719)1813004 UNRESTRICTED FullTexts -- missing cx lookup -- 10.1016/S1474-4422(08)70224-2 Crossref 10.1016/S1474-4422(08)70224-2 -- missing cx lookup -- 10.1016/S1474-4422(12)70310-1 Crossref 10.1016/S1474-4422(12)70310-1 -- missing cx lookup -- 10.1002/ana.24083 Crossref 10.1002/ana.24083 -- missing cx lookup -- 10.1002/ana.23689 Crossref 10.1002/ana.23689 -- missing cx lookup -- 10.1002/acn3.444 Crossref 10.1002/acn3.444 -- missing cx lookup -- 10.1093/brain/awu310 Crossref 10.1093/brain/awu310 -- missing cx lookup -- 10.1093/brain/aww208 Crossref 10.1093/brain/aww208 -- missing cx lookup -- 10.1016/j.jim.2007.09.017 Crossref 10.1016/j.jim.2007.09.017 -- missing cx lookup -- 10.1126/science.1086907 Crossref 10.1126/science.1086907 -- missing cx lookup -- 10.1126/sciimmunol.aap8029 Crossref 10.1126/sciimmunol.aap8029 -- missing cx lookup -- 10.1007/s00415-018-9042-1 Crossref 10.1007/s00415-018-9042-1 -- missing cx lookup -- 10.1093/brain/awv324 Crossref 10.1093/brain/awv324 -- missing cx lookup -- 10.3389/fnsyn.2015.00016 Crossref 10.3389/fnsyn.2015.00016 2012 Crossref AMBER 12 Case DA AMBER 12 2012 1961 Crossref Helmreich E 1961 -- missing cx lookup -- 10.1002/eji.1830160206 Crossref 10.1002/eji.1830160206 -- missing cx lookup -- 10.1002/ana.24189 Crossref 10.1002/ana.24189 -- missing cx lookup -- 10.1172/JCI78083 Crossref 10.1172/JCI78083 -- missing cx lookup -- 10.1016/j.coi.2008.09.001 Crossref 10.1016/j.coi.2008.09.001 -- missing cx lookup -- 10.1002/ana.25173 Crossref 10.1002/ana.25173 -- missing cx lookup -- 10.1093/brain/awy010 Crossref 10.1093/brain/awy010 -- missing cx lookup -- 10.1001/jamaneurol.2014.488 Crossref 10.1001/jamaneurol.2014.488 -- missing cx lookup -- 10.1097/PGP.0b013e31824a1de2 Crossref 10.1097/PGP.0b013e31824a1de2 -- missing cx lookup -- 10.1242/dmm.020727 Crossref 10.1242/dmm.020727 -- missing cx lookup -- 10.1001/jamaneurol.2015.2188 Crossref 10.1001/jamaneurol.2015.2188 -- missing cx lookup -- 10.1097/00005072-198701000-00008 Crossref 10.1097/00005072-198701000-00008 -- missing cx lookup -- 10.1161/STROKEAHA.114.008323 Crossref 10.1161/STROKEAHA.114.008323 -- missing cx lookup -- 10.1084/jem.20160201 Crossref 10.1084/jem.20160201 -- missing cx lookup -- 10.1523/JNEUROSCI.0064-12.2012 Crossref 10.1523/JNEUROSCI.0064-12.2012