%0 Journal Article
%A Piper, Sophie K
%A Grittner, Ulrike
%A Rex, Andre
%A Riedel, Nico
%A Fischer, Felix
%A Nadon, Robert
%A Siegerink, Bob
%A Dirnagl, Ulrich
%T Exact replication: Foundation of science or game of chance?
%J PLoS biology
%V 17
%N 4
%@ 1545-7885
%C Lawrence, KS
%I PLoS
%M DZNE-2020-06992
%P e3000188
%D 2019
%X The need for replication of initial results has been rediscovered only recently in many fields of research. In preclinical biomedical research, it is common practice to conduct exact replications with the same sample sizes as those used in the initial experiments. Such replication attempts, however, have lower probability of replication than is generally appreciated. Indeed, in the common scenario of an effect just reaching statistical significance, the statistical power of the replication experiment assuming the same effect size is approximately 50
%K Animals
%K Bayes Theorem
%K Biomedical Research: methods
%K Biomedical Research: statistics & numerical data
%K Data Interpretation, Statistical
%K Humans
%K Models, Statistical
%K Probability
%K Publications
%K Reproducibility of Results
%K Research Design: statistics & numerical data
%K Sample Size
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:30964856
%2 pmc:PMC6456162
%R 10.1371/journal.pbio.3000188
%U https://pub.dzne.de/record/140670