TY  - JOUR
AU  - Piper, Sophie K
AU  - Grittner, Ulrike
AU  - Rex, Andre
AU  - Riedel, Nico
AU  - Fischer, Felix
AU  - Nadon, Robert
AU  - Siegerink, Bob
AU  - Dirnagl, Ulrich
TI  - Exact replication: Foundation of science or game of chance?
JO  - PLoS biology
VL  - 17
IS  - 4
SN  - 1545-7885
CY  - Lawrence, KS
PB  - PLoS
M1  - DZNE-2020-06992
SP  - e3000188
PY  - 2019
AB  - The need for replication of initial results has been rediscovered only recently in many fields of research. In preclinical biomedical research, it is common practice to conduct exact replications with the same sample sizes as those used in the initial experiments. Such replication attempts, however, have lower probability of replication than is generally appreciated. Indeed, in the common scenario of an effect just reaching statistical significance, the statistical power of the replication experiment assuming the same effect size is approximately 50
KW  - Animals
KW  - Bayes Theorem
KW  - Biomedical Research: methods
KW  - Biomedical Research: statistics & numerical data
KW  - Data Interpretation, Statistical
KW  - Humans
KW  - Models, Statistical
KW  - Probability
KW  - Publications
KW  - Reproducibility of Results
KW  - Research Design: statistics & numerical data
KW  - Sample Size
LB  - PUB:(DE-HGF)16
C6  - pmid:30964856
C2  - pmc:PMC6456162
DO  - DOI:10.1371/journal.pbio.3000188
UR  - https://pub.dzne.de/record/140670
ER  -