140673 20240321220843.0 10.1016/j.jmb.2019.01.019 doi pmid:30664869 pmid 0022-2836 ISSN 1089-8638 ISSN altmetric:70432503 altmetric DZNE-2020-06995 English 610 Krauss, Sybille P:(DE-2719)2421562 0 First author dzne The Role of MicroRNAs in Spinocerebellar Ataxia Type 3. Amsterdam [u.a.] 2019 Elsevier print Crossref Elsevier BV 2019-04-01 article DRIVER Output Types/Journal article DataCite Journal Article journal journal PUB:(DE-HGF)16 1685012194_32156 PUB:(DE-HGF) Review Article ARTICLE BibTeX JOURNAL_ARTICLE ORCID Journal Article 0 EndNote More than 90% of the human genome are transcribed as non-coding RNAs. While it is still under debate if all these non-coding transcripts are functional, there is emerging evidence that RNA has several important functions in addition to coding for proteins. For example, microRNAs (miRNAs) are important regulatory RNAs that control gene expression in various biological processes and human diseases. In spinocerebellar ataxia type 3 (SCA3), a devastating neurodegenerative disease, miRNAs are involved in the disease process at different levels, including the deregulation of components of the general miRNA biogenesis machinery, as well as in the cell type-specific control of the expression of the SCA3 disease protein and other SCA3 disease-relevant proteins. However, it remains difficult to predict whether these changes are a cause or a consequence of the neurodegenerative process in SCA3. Further studies using standardized procedures for the analysis of miRNA expression and larger sample numbers are required to enhance our understanding of the miRNA-mediated processes involved in SCA3 disease and may enable the development of miRNA-based therapeutics. In this review, we summarize the findings of independent studies highlighting both the disease-related and cytoprotective roles of miRNAs that have been implicated so far in the disease process of SCA3. 342 - Disease Mechanisms and Model Systems (POF3-342) G:(DE-HGF)POF3-342 POF3-342 POF III 0 2019-04-01 Crossref https://www.elsevier.com/tdm/userlicense/1.0/ 2019-01-30 Crossref http://creativecommons.org/licenses/by-nc-nd/4.0/ Dataset connected to CrossRef, PubMed, Animals MeSH Ataxin-3: genetics MeSH Ataxin-3: metabolism MeSH Biomarkers: metabolism MeSH Brain: metabolism MeSH Brain: pathology MeSH Cell Line MeSH Disease Models, Animal MeSH Drosophila melanogaster: genetics MeSH Drosophila melanogaster: metabolism MeSH Gene Expression Regulation MeSH Humans MeSH Lymphocytes: metabolism MeSH Lymphocytes: pathology MeSH Machado-Joseph Disease: genetics MeSH Machado-Joseph Disease: metabolism MeSH Machado-Joseph Disease: pathology MeSH Machado-Joseph Disease: therapy MeSH Mice MeSH MicroRNAs: genetics MeSH MicroRNAs: metabolism MeSH Molecular Targeted Therapy: methods MeSH Neurons: metabolism MeSH Neurons: pathology MeSH Repressor Proteins: genetics MeSH Repressor Proteins: metabolism MeSH Signal Transduction MeSH Evert, Bernd O P:(DE-HGF)0 1 Corresponding author 10.1016/j.jmb.2019.01.019 : Elsevier BV, 2019-04-01 9 1729-1742 journal-article Crossref Journal of Molecular Biology 431 2019 0022-2836 10.1016/j.jmb.2019.01.019 Vol. 431, no. 9, p. 1729 - 1742 PERI:(DE-600)1355192-9 9 431:9<1729 - 1742 1729-1742 Journal of molecular biology 431 2019 0022-2836 OpenAccess http://pub.dzne.de/record/140673/files/DZNE-2020-06995.pdf OpenAccess pdfa http://pub.dzne.de/record/140673/files/DZNE-2020-06995.pdf?subformat=pdfa oai:pub.dzne.de:140673 openaire open_access VDB driver dnbdelivery Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 0 P:(DE-2719)2421562 DE-HGF Gesundheit Erkrankungen des Nervensystems G:(DE-HGF)POF3-340 G:(DE-HGF)POF3-342 G:(DE-HGF)POF3 G:(DE-HGF)POF3-300 G:(DE-HGF)POF Disease Mechanisms and Model Systems 0 2019 Creative Commons Attribution-NonCommercial-NoDerivs CC BY-NC-ND 4.0 LIC:(DE-HGF)CCBYNCND4 HGFVOC OpenAccess StatID:(DE-HGF)0510 StatID Nationallizenz StatID:(DE-HGF)0420 StatID 2022-11-08 ger JCR StatID:(DE-HGF)0100 StatID J MOL BIOL : 2021 2022-11-08 DBCoverage StatID:(DE-HGF)0200 StatID SCOPUS 2022-11-08 DBCoverage StatID:(DE-HGF)0300 StatID Medline 2022-11-08 DBCoverage StatID:(DE-HGF)0600 StatID Ebsco Academic Search 2022-11-08 Peer Review StatID:(DE-HGF)0030 StatID ASC 2022-11-08 DBCoverage StatID:(DE-HGF)0199 StatID Clarivate Analytics Master Journal List 2022-11-08 DBCoverage StatID:(DE-HGF)0150 StatID Web of Science Core Collection 2022-11-08 DBCoverage StatID:(DE-HGF)1050 StatID BIOSIS Previews 2022-11-08 DBCoverage StatID:(DE-HGF)1030 StatID Current Contents - Life Sciences 2022-11-08 IF >= 5 StatID:(DE-HGF)9905 StatID J MOL BIOL : 2021 2022-11-08 I:(DE-2719)1011006 AG Krauß ; AG Krauß Regulatory RNA-protein interaction in neurodegenerative diseases 0 journal VDB UNRESTRICTED I:(DE-2719)1011006 FullTexts