140772 20240321220854.0 10.1111/ene.13920 doi pmid:30706590 pmid 1351-5101 ISSN 1468-1331 ISSN 1471-0552 ISSN altmetric:54900454 altmetric DZNE-2020-07094 English 610 Erdur, H. P:(DE-HGF)0 0 Corresponding author Myocardial injury in transient global amnesia: a case-control study. Oxford 2019 Blackwell Science78889 online Crossref Wiley 2019-02-21 print Crossref Wiley 2019-07-01 article DRIVER Output Types/Journal article DataCite Journal Article journal journal PUB:(DE-HGF)16 1592492814_24922 PUB:(DE-HGF) ARTICLE BibTeX JOURNAL_ARTICLE ORCID Journal Article 0 EndNote Elevation of cardiac troponin (cTn), a sensitive biomarker of myocardial injury, is frequently observed in severe acute neurological disorders. Case reports suggest that cardiac dysfunction may also occur in patients with transient global amnesia (TGA). Until now, no study has systematically assessed this phenomenon.We performed a case-control study using data of consecutive patients presenting with TGA from 2010 to 2015. Multiple logistic regression analysis accounting for age, sex and cardiovascular risk factors was performed to compare the likelihood of myocardial injury [defined as elevation of cTn > 99th percentile (≥14 ng/L); highly sensitive cardiac troponin T assay] in TGA with three reference groups: migraine with aura, vestibular neuritis and transient ischaemic attack (TIA).Cardiac troponin elevation occurred in 28 (25%) of 113 patients with TGA. Patients with TGA with cTn elevation were significantly older, more likely to be female and had higher blood pressure on admission compared with those without. The likelihood of myocardial injury following TGA was at least more than twofold higher compared with all three reference groups [adjusted odds ratio, 5.5; 95% confidence interval (CI), 1.2-26.4, compared with migraine with aura; adjusted odds ratio, 2.2; 95% CI, 1.2-4.4, compared with vestibular neuritis; adjusted odds ratio, 2.3; 95% CI, 1.3-4.2, compared with TIA].One out of four patients with TGA had evidence of myocardial injury as assessed by highly sensitive cTn assays. The likelihood of myocardial injury associated with TGA was even higher than in TIA patients with a more pronounced cardiovascular risk profile. Our findings suggest the presence of a TGA-related disturbance of brain-heart interaction that deserves further investigation. 899H - Addenda (POF3-899H) G:(DE-HGF)POF3-899H POF3-899H POF III 0 2019-02-21 Crossref http://doi.wiley.com/10.1002/tdm_license_1.1 2019-02-21 Crossref http://onlinelibrary.wiley.com/termsAndConditions#vor Dataset connected to CrossRef, PubMed, Aged MeSH Aged, 80 and over MeSH Amnesia, Transient Global: blood MeSH Amnesia, Transient Global: complications MeSH Case-Control Studies MeSH Female MeSH Heart Diseases: blood MeSH Heart Diseases: complications MeSH Humans MeSH Ischemic Attack, Transient: blood MeSH Ischemic Attack, Transient: complications MeSH Male MeSH Middle Aged MeSH Migraine Disorders: blood MeSH Migraine Disorders: complications MeSH Risk Factors MeSH Troponin T: blood MeSH Siegerink, B. 1 Ganeshan, R. 2 Audebert, H. J. 3 Endres, M. P:(DE-2719)2811033 4 dzne Nolte, C. H. P:(DE-2719)9000234 5 dzne Scheitz, J. 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