141060 20240321220922.0 10.1016/j.dib.2017.10.024 doi pmid:29124088 pmid pmc:PMC5671473 pmc altmetric:27768745 altmetric DZNE-2020-07382 English 570 Baker, Suzanne L P:(DE-HGF)0 0 Corresponding author Considerations and code for partial volume correcting [18F]-AV-1451 tau PET data. Amsterdam [u.a.] 2017 Elsevier print Crossref Elsevier BV 2017-12-01 article DRIVER Output Types/Journal article DataCite Journal Article journal journal PUB:(DE-HGF)16 1709826311_6139 PUB:(DE-HGF) ARTICLE BibTeX JOURNAL_ARTICLE ORCID Journal Article 0 EndNote [18F]-AV-1451 is a leading tracer used with positron emission tomography (PET) to quantify tau pathology. However, [18F]-AV-1451 shows 'off target' or non-specific binding, which we define as binding of the tracer in unexpected areas unlikely to harbor aggregated tau based on autopsy literature [1]. Along with caudate, putamen, pallidum and thalamus non-specific binding [2], [3], we have found binding in the superior portion of the cerebellar gray matter, leading us to use inferior cerebellar gray as the reference region. We also addressed binding in the posterior portion of the choroid plexus. PET signal unlikely to be associated with tau also occurs in skull, meninges and soft tissue (see e.g. [4]). We refer to [18F]-AV-1451 binding in the skull and meninges as extra-cortical hotspots (ECH) and find them near lateral and medial orbitofrontal, lateral occipital, inferior and middle temporal, superior and inferior parietal, and inferior cerebellar gray matter. Lastly, the choroid plexus also shows non-specific binding that bleeds into hippocampus. We are providing the code (http://www.runmycode.org/companion/view/2798) used to create different regions of interest (ROIs) that we then used to perform Partial Volume Correction (PVC) using the Rousset geometric transfer matrix method (GTM, [5]). This method was used in the companion article, 'Comparison of multiple tau-PET measures as biomarkers in aging and Alzheimer's Disease' ([6], DOI 10.1016/j.neuroimage.2017.05.058). 344 - Clinical and Health Care Research (POF3-344) G:(DE-HGF)POF3-344 POF3-344 POF III 0 2017-12-01 Crossref https://www.elsevier.com/tdm/userlicense/1.0/ 2017-10-13 Crossref http://creativecommons.org/licenses/by/4.0/ Dataset connected to CrossRef, PubMed, Maaß, Anne P:(DE-2719)2811815 1 dzne Jagust, William J P:(DE-HGF)0 2 10.1016/j.dib.2017.10.024 : Elsevier BV, 2017-12-01 648-657 journal-article Crossref Data in Brief 15 2017 2352-3409 10.1016/j.dib.2017.10.024 Vol. 15, p. 648 - 657 PERI:(DE-600)2786545-9 15<648 - 657 648-657 Data in Brief 15 2017 2352-3409 Maaß, Anne et.al. Orlando, Fla. : Academic Press, 2017 RelatedTo DZNE-2020-05825 Comparison of multiple tau-PET measures as biomarkers in aging and Alzheimer's disease. OpenAccess http://pub.dzne.de/record/141060/files/DZNE-2020-07382.pdf OpenAccess pdfa http://pub.dzne.de/record/141060/files/DZNE-2020-07382.pdf?subformat=pdfa Pubmed Central http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5671473 oai:pub.dzne.de:141060 openaire open_access VDB driver dnbdelivery Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 1 P:(DE-2719)2811815 DE-HGF Gesundheit Erkrankungen des Nervensystems G:(DE-HGF)POF3-340 G:(DE-HGF)POF3-344 G:(DE-HGF)POF3 G:(DE-HGF)POF3-300 G:(DE-HGF)POF Clinical and Health Care Research 0 2017 DBCoverage StatID:(DE-HGF)0200 StatID SCOPUS 2022-11-30 DBCoverage StatID:(DE-HGF)1050 StatID BIOSIS Previews 2022-11-30 Creative Commons Attribution CC BY 4.0 LIC:(DE-HGF)CCBY4 HGFVOC WoS StatID:(DE-HGF)0112 StatID Emerging Sources Citation Index 2022-11-30 DBCoverage StatID:(DE-HGF)0501 StatID DOAJ Seal 2021-05-31T09:03:54Z DBCoverage StatID:(DE-HGF)0500 StatID DOAJ 2021-05-31T09:03:54Z DBCoverage StatID:(DE-HGF)0150 StatID Web of Science Core Collection 2022-11-30 OpenAccess StatID:(DE-HGF)0510 StatID Peer Review StatID:(DE-HGF)0030 StatID DOAJ : Blind peer review 2021-05-31T09:03:54Z DBCoverage StatID:(DE-HGF)0300 StatID Medline 2022-11-30 DBCoverage StatID:(DE-HGF)0199 StatID Clarivate Analytics Master Journal List 2022-11-30 I:(DE-2719)5000006 AG Düzel Clinical Neurophysiology and Memory 0 journal VDB UNRESTRICTED I:(DE-2719)5000006 FullTexts