141558 20240321220957.0 10.1038/s41598-019-49920-5 doi pmid:31527656 pmid pmc:PMC6746949 pmc altmetric:66702492 altmetric DZNE-2020-07882 English 600 Schweyer, Kerstin P:(DE-2719)2811446 0 First author Neuronal precursor cells with dopaminergic commitment in the rostral migratory stream of the mouse. [London] 2019 Macmillan Publishers Limited, part of Springer Nature online Crossref Springer Science and Business Media LLC 2019-09-16 print Crossref Springer Science and Business Media LLC 2019-12-01 article DRIVER Output Types/Journal article DataCite Journal Article journal journal PUB:(DE-HGF)16 1604933536_8065 PUB:(DE-HGF) ARTICLE BibTeX JOURNAL_ARTICLE ORCID Journal Article 0 EndNote Neuroblasts born in the subventricular zone of adult mammals migrate via the rostral migratory stream into the granular cell layer or periglomerular layer of the olfactory bulb to differentiate into interneurons. To analyze if new neurons in the granular cell layer or periglomerular layer have different origins, we inserted a physical barrier into the rostral migratory stream, depleted cell proliferation with cytarabine infusions, labeled newborn cells with bromodeoxyuridine, and sacrificed mice after short-term (0, 2, or 14 days) or long-term (55 or 105 days) intervals. After short-term survival, the subventricular zone and rostral migratory stream rapidly repopulated with bromodeoxyuridine+ cells after cytarabine-induced depletion. Nestin, glial fibrillary acidic protein and the PAX6 were expressed in bromodeoxyuridine+ cells within the rostral migratory stream downstream of the physical barrier. After long-term survival after physical barrier implantation, bromodeoxyuridine+ neurons were significantly reduced in the granular cell layer, but bromodeoxyuridine+ and dopaminergic neurons in the periglomerular layer remained unaffected by the physical barrier. Thus, newborn neurons for the granular cell layer are mainly recruited from neural stem cells located in the subventricular zone, but new neurons for the periglomerular layer with dopaminergic predisposition can rise as well from neuronal stem or precursor cells in the rostral migratory stream. 344 - Clinical and Health Care Research (POF3-344) G:(DE-HGF)POF3-344 POF3-344 POF III 0 2019-09-16 Crossref https://creativecommons.org/licenses/by/4.0 Dataset connected to CrossRef, PubMed, Animals MeSH Bromodeoxyuridine: metabolism MeSH Cell Differentiation: physiology MeSH Cell Movement: physiology MeSH Cell Proliferation: physiology MeSH Dopamine: metabolism MeSH Dopaminergic Neurons: metabolism MeSH Interneurons: metabolism MeSH Lateral Ventricles: metabolism MeSH Male MeSH Mice MeSH Mice, Inbred C57BL MeSH Neural Stem Cells: metabolism MeSH Neural Stem Cells: physiology MeSH Olfactory Bulb: metabolism MeSH Rüschoff-Steiner, Corinna P:(DE-HGF)0 1 Arias-Carrión, Oscar P:(DE-HGF)0 2 Oertel, Wolfgang H P:(DE-HGF)0 3 Rösler, Thomas W P:(DE-2719)2810437 4 Höglinger, Günter P:(DE-2719)2811373 5 Last author 10.1038/s41598-019-49920-5 : Springer Science and Business Media LLC, 2019-09-16 1 13359 journal-article Crossref Scientific Reports 9 2019 2045-2322 10.1038/s41598-019-49920-5 Vol. 9, no. 1, p. 13359 PERI:(DE-600)2615211-3 1 9:1<13359 13359 Scientific reports 9 2019 2045-2322 OpenAccess http://pub.dzne.de/record/141558/files/s41598-019-49920-5.pdf OpenAccess icon http://pub.dzne.de/record/141558/files/s41598-019-49920-5.gif?subformat=icon OpenAccess icon-1440 http://pub.dzne.de/record/141558/files/s41598-019-49920-5.jpg?subformat=icon-1440 OpenAccess icon-180 http://pub.dzne.de/record/141558/files/s41598-019-49920-5.jpg?subformat=icon-180 OpenAccess icon-640 http://pub.dzne.de/record/141558/files/s41598-019-49920-5.jpg?subformat=icon-640 OpenAccess pdfa http://pub.dzne.de/record/141558/files/s41598-019-49920-5.pdf?subformat=pdfa Pubmed Central http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6746949 oai:pub.dzne.de:141558 openaire open_access VDB driver dnbdelivery Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 0 P:(DE-2719)2811446 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 4 P:(DE-2719)2810437 Deutsches Zentrum für Neurodegenerative Erkrankungen I:(DE-588)1065079516 DZNE 5 P:(DE-2719)2811373 DE-HGF Forschungsbereich Gesundheit Erkrankungen des Nervensystems G:(DE-HGF)POF3-340 G:(DE-HGF)POF3-344 G:(DE-HGF)POF3-300 Clinical and Health Care Research 0 2019 Creative Commons Attribution CC BY (No Version) LIC:(DE-HGF)CCBYNV V:(DE-HGF) DOAJ OpenAccess StatID:(DE-HGF)0510 StatID JCR StatID:(DE-HGF)0100 StatID SCI REP-UK : 2021 2023-03-30 DBCoverage StatID:(DE-HGF)0200 StatID SCOPUS 2023-03-30 DBCoverage StatID:(DE-HGF)0300 StatID Medline 2023-03-30 DBCoverage StatID:(DE-HGF)0501 StatID DOAJ Seal 2022-08-08T09:38:07Z DBCoverage StatID:(DE-HGF)0500 StatID DOAJ 2022-08-08T09:38:07Z Peer Review StatID:(DE-HGF)0030 StatID DOAJ : Blind peer review 2022-08-08T09:38:07Z DBCoverage StatID:(DE-HGF)0600 StatID Ebsco Academic Search 2023-03-30 Peer Review StatID:(DE-HGF)0030 StatID ASC 2023-03-30 DBCoverage StatID:(DE-HGF)0199 StatID Clarivate Analytics Master Journal List 2023-03-30 DBCoverage StatID:(DE-HGF)0150 StatID Web of Science Core Collection 2023-03-30 DBCoverage StatID:(DE-HGF)1050 StatID BIOSIS Previews 2023-03-30 DBCoverage StatID:(DE-HGF)1040 StatID Zoological Record 2023-03-30 DBCoverage StatID:(DE-HGF)1150 StatID Current Contents - Physical, Chemical and Earth Sciences 2023-03-30 IF < 5 StatID:(DE-HGF)9900 StatID 2023-03-30 I:(DE-2719)1110002 AG Höglinger 1 Translational Neurodegeneration 0 journal VDB UNRESTRICTED I:(DE-2719)1110002 FullTexts -- missing cx lookup -- 10.1016/j.neuron.2011.05.001 Crossref 10.1016/j.neuron.2011.05.001 -- missing cx lookup -- 10.1038/nrn1867 Crossref 10.1038/nrn1867 -- missing cx lookup -- 10.1073/pnas.92.25.11879 Crossref 10.1073/pnas.92.25.11879 -- missing cx lookup -- 10.1016/S0079-6123(02)38067-1 Crossref 10.1016/S0079-6123(02)38067-1 -- missing cx lookup -- 10.1038/nrn2147 Crossref 10.1038/nrn2147 -- missing cx lookup -- 10.1242/dev.085852 Crossref 10.1242/dev.085852 -- missing cx lookup -- 10.1016/S0092-8674(00)80783-7 Crossref 10.1016/S0092-8674(00)80783-7 -- missing cx lookup -- 10.1523/JNEUROSCI.17-13-05046.1997 Crossref 10.1523/JNEUROSCI.17-13-05046.1997 -- missing cx lookup -- 10.1046/j.1460-9568.2002.02238.x Crossref 10.1046/j.1460-9568.2002.02238.x -- missing cx lookup -- 10.1523/JNEUROSCI.22-03-00629.2002 Crossref 10.1523/JNEUROSCI.22-03-00629.2002 -- missing cx lookup -- 10.1016/0168-0102(95)90017-9 Crossref 10.1016/0168-0102(95)90017-9 -- missing cx lookup -- 10.1523/JNEUROSCI.22-02-00437.2002 Crossref 10.1523/JNEUROSCI.22-02-00437.2002 -- missing cx lookup -- 10.1523/JNEUROSCI.3713-08.2008 Crossref 10.1523/JNEUROSCI.3713-08.2008 -- missing cx lookup -- 10.1101/sqb.2008.73.019 Crossref 10.1101/sqb.2008.73.019 -- missing cx lookup -- 10.1016/j.neures.2007.11.013 Crossref 10.1016/j.neures.2007.11.013 -- missing cx lookup -- 10.3389/fnins.2016.00189 Crossref 10.3389/fnins.2016.00189 -- missing cx lookup -- 10.1126/science.1144914 Crossref 10.1126/science.1144914 -- missing cx lookup -- 10.1111/j.1460-9568.2009.06798.x Crossref 10.1111/j.1460-9568.2009.06798.x -- missing cx lookup -- 10.1038/nn1479 Crossref 10.1038/nn1479 -- missing cx lookup -- 10.1523/JNEUROSCI.1435-05.2005 Crossref 10.1523/JNEUROSCI.1435-05.2005 -- missing cx lookup -- 10.1016/j.neuron.2010.09.030 Crossref 10.1016/j.neuron.2010.09.030 -- missing cx lookup -- 10.1002/(SICI)1096-9861(19990322)405:4<508::AID-CNE5>3.0.CO;2-5 Crossref 10.1002/(SICI)1096-9861(19990322)405:4<508::AID-CNE5>3.0.CO;2-5 -- missing cx lookup -- 10.1046/j.1460-9568.1998.00397.x Crossref 10.1046/j.1460-9568.1998.00397.x -- missing cx lookup -- 10.1016/0306-4522(94)90397-2 Crossref 10.1016/0306-4522(94)90397-2 -- missing cx lookup -- 10.1016/j.neuroscience.2009.12.026 Crossref 10.1016/j.neuroscience.2009.12.026 -- missing cx lookup -- 10.1073/pnas.96.20.11619 Crossref 10.1073/pnas.96.20.11619 -- missing cx lookup -- 10.1523/JNEUROSCI.4608-03.2004 Crossref 10.1523/JNEUROSCI.4608-03.2004 -- missing cx lookup -- 10.1038/nn1265 Crossref 10.1038/nn1265 -- missing cx lookup -- 10.1038/srep32203 Crossref 10.1038/srep32203 Crossref -- missing cx lookup -- 10.1073/pnas.93.25.14895 Crossref 10.1073/pnas.93.25.14895