%0 Journal Article
%A Harrison, Theresa M
%A Maaß, Anne
%A Adams, Jenna N
%A Du, Richard
%A Baker, Suzanne L
%A Jagust, William J
%T Tau deposition is associated with functional isolation of the hippocampus in aging.
%J Nature Communications
%V 10
%N 1
%@ 2041-1723
%C [London]
%I Nature Publishing Group UK
%M DZNE-2020-07924
%P 4900
%D 2019
%X The tau protein aggregates in aging and Alzheimer disease and may lead to memory loss through disruption of medial temporal lobe (MTL)-dependent memory systems. Here, we investigated tau-mediated mechanisms of hippocampal dysfunction that underlie the expression of episodic memory decline using fMRI measures of hippocampal local coherence (regional homogeneity; ReHo), distant functional connectivity and tau-PET. We show that age and tau pathology are related to higher hippocampal ReHo. Functional disconnection between the hippocampus and other components of the MTL memory system, particularly an anterior-temporal network specialized for object memory, is also associated with higher hippocampal ReHo and greater tau burden in anterior-temporal regions. These associations are not observed in the posteromedial network, specialized for context/spatial information. Higher hippocampal ReHo predicts worse memory performance. These findings suggest that tau pathology plays a role in disconnecting the hippocampus from specific MTL memory systems leading to increased local coherence and memory decline.
%K Adult
%K Aged
%K Aged, 80 and over
%K Aging: metabolism
%K Aging: physiology
%K Aging: psychology
%K Alzheimer Disease: diagnostic imaging
%K Alzheimer Disease: metabolism
%K Alzheimer Disease: physiopathology
%K Alzheimer Disease: psychology
%K Amyloid beta-Peptides: metabolism
%K Aniline Compounds
%K Brain: diagnostic imaging
%K Brain: metabolism
%K Brain: physiopathology
%K Carbolines
%K Cognitive Aging: physiology
%K Cognitive Aging: psychology
%K Contrast Media
%K Entorhinal Cortex: diagnostic imaging
%K Entorhinal Cortex: metabolism
%K Entorhinal Cortex: physiopathology
%K Executive Function
%K Female
%K Functional Neuroimaging
%K Hippocampus: diagnostic imaging
%K Hippocampus: metabolism
%K Hippocampus: physiopathology
%K Humans
%K Male
%K Memory, Episodic
%K Memory, Short-Term
%K Middle Aged
%K Neural Pathways: diagnostic imaging
%K Neural Pathways: metabolism
%K Neural Pathways: physiopathology
%K Neurofibrillary Tangles: metabolism
%K Positron-Emission Tomography
%K Temporal Lobe: diagnostic imaging
%K Temporal Lobe: metabolism
%K Temporal Lobe: physiology
%K Thiazoles
%K Young Adult
%K tau Proteins: metabolism
%K 2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole (NLM Chemicals)
%K Amyloid beta-Peptides (NLM Chemicals)
%K Aniline Compounds (NLM Chemicals)
%K Carbolines (NLM Chemicals)
%K Contrast Media (NLM Chemicals)
%K MAPT protein, human (NLM Chemicals)
%K Thiazoles (NLM Chemicals)
%K tau Proteins (NLM Chemicals)
%K 7-(6-fluoropyridin-3-yl)-5H-pyrido(4,3-b)indole (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:31653847
%2 pmc:PMC6814780
%R 10.1038/s41467-019-12921-z
%U https://pub.dzne.de/record/141600