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000141600 037__ $$aDZNE-2020-07924
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000141600 1001_ $$0P:(DE-HGF)0$$aHarrison, Theresa M$$b0$$eCorresponding author
000141600 245__ $$aTau deposition is associated with functional isolation of the hippocampus in aging.
000141600 260__ $$a[London]$$bNature Publishing Group UK$$c2019
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000141600 520__ $$aThe tau protein aggregates in aging and Alzheimer disease and may lead to memory loss through disruption of medial temporal lobe (MTL)-dependent memory systems. Here, we investigated tau-mediated mechanisms of hippocampal dysfunction that underlie the expression of episodic memory decline using fMRI measures of hippocampal local coherence (regional homogeneity; ReHo), distant functional connectivity and tau-PET. We show that age and tau pathology are related to higher hippocampal ReHo. Functional disconnection between the hippocampus and other components of the MTL memory system, particularly an anterior-temporal network specialized for object memory, is also associated with higher hippocampal ReHo and greater tau burden in anterior-temporal regions. These associations are not observed in the posteromedial network, specialized for context/spatial information. Higher hippocampal ReHo predicts worse memory performance. These findings suggest that tau pathology plays a role in disconnecting the hippocampus from specific MTL memory systems leading to increased local coherence and memory decline.
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000141600 542__ $$2Crossref$$i2019-10-25$$uhttps://creativecommons.org/licenses/by/4.0
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000141600 650_7 $$2NLM Chemicals$$a2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole
000141600 650_7 $$2NLM Chemicals$$aAmyloid beta-Peptides
000141600 650_7 $$2NLM Chemicals$$aAniline Compounds
000141600 650_7 $$2NLM Chemicals$$aCarbolines
000141600 650_7 $$2NLM Chemicals$$aContrast Media
000141600 650_7 $$2NLM Chemicals$$aMAPT protein, human
000141600 650_7 $$2NLM Chemicals$$aThiazoles
000141600 650_7 $$2NLM Chemicals$$atau Proteins
000141600 650_7 $$0J09QS3Z3WB$$2NLM Chemicals$$a7-(6-fluoropyridin-3-yl)-5H-pyrido(4,3-b)indole
000141600 650_2 $$2MeSH$$aAdult
000141600 650_2 $$2MeSH$$aAged
000141600 650_2 $$2MeSH$$aAged, 80 and over
000141600 650_2 $$2MeSH$$aAging: metabolism
000141600 650_2 $$2MeSH$$aAging: physiology
000141600 650_2 $$2MeSH$$aAging: psychology
000141600 650_2 $$2MeSH$$aAlzheimer Disease: diagnostic imaging
000141600 650_2 $$2MeSH$$aAlzheimer Disease: metabolism
000141600 650_2 $$2MeSH$$aAlzheimer Disease: physiopathology
000141600 650_2 $$2MeSH$$aAlzheimer Disease: psychology
000141600 650_2 $$2MeSH$$aAmyloid beta-Peptides: metabolism
000141600 650_2 $$2MeSH$$aAniline Compounds
000141600 650_2 $$2MeSH$$aBrain: diagnostic imaging
000141600 650_2 $$2MeSH$$aBrain: metabolism
000141600 650_2 $$2MeSH$$aBrain: physiopathology
000141600 650_2 $$2MeSH$$aCarbolines
000141600 650_2 $$2MeSH$$aCognitive Aging: physiology
000141600 650_2 $$2MeSH$$aCognitive Aging: psychology
000141600 650_2 $$2MeSH$$aContrast Media
000141600 650_2 $$2MeSH$$aEntorhinal Cortex: diagnostic imaging
000141600 650_2 $$2MeSH$$aEntorhinal Cortex: metabolism
000141600 650_2 $$2MeSH$$aEntorhinal Cortex: physiopathology
000141600 650_2 $$2MeSH$$aExecutive Function
000141600 650_2 $$2MeSH$$aFemale
000141600 650_2 $$2MeSH$$aFunctional Neuroimaging
000141600 650_2 $$2MeSH$$aHippocampus: diagnostic imaging
000141600 650_2 $$2MeSH$$aHippocampus: metabolism
000141600 650_2 $$2MeSH$$aHippocampus: physiopathology
000141600 650_2 $$2MeSH$$aHumans
000141600 650_2 $$2MeSH$$aMale
000141600 650_2 $$2MeSH$$aMemory, Episodic
000141600 650_2 $$2MeSH$$aMemory, Short-Term
000141600 650_2 $$2MeSH$$aMiddle Aged
000141600 650_2 $$2MeSH$$aNeural Pathways: diagnostic imaging
000141600 650_2 $$2MeSH$$aNeural Pathways: metabolism
000141600 650_2 $$2MeSH$$aNeural Pathways: physiopathology
000141600 650_2 $$2MeSH$$aNeurofibrillary Tangles: metabolism
000141600 650_2 $$2MeSH$$aPositron-Emission Tomography
000141600 650_2 $$2MeSH$$aTemporal Lobe: diagnostic imaging
000141600 650_2 $$2MeSH$$aTemporal Lobe: metabolism
000141600 650_2 $$2MeSH$$aTemporal Lobe: physiology
000141600 650_2 $$2MeSH$$aThiazoles
000141600 650_2 $$2MeSH$$aYoung Adult
000141600 650_2 $$2MeSH$$atau Proteins: metabolism
000141600 7001_ $$0P:(DE-2719)2811815$$aMaaß, Anne$$b1$$udzne
000141600 7001_ $$aAdams, Jenna N$$b2
000141600 7001_ $$aDu, Richard$$b3
000141600 7001_ $$aBaker, Suzanne L$$b4
000141600 7001_ $$aJagust, William J$$b5
000141600 77318 $$2Crossref$$3journal-article$$a10.1038/s41467-019-12921-z$$b : Springer Science and Business Media LLC, 2019-10-25$$n1$$p4900$$tNature Communications$$v10$$x2041-1723$$y2019
000141600 773__ $$0PERI:(DE-600)2553671-0$$a10.1038/s41467-019-12921-z$$gVol. 10, no. 1, p. 4900$$n1$$p4900$$q10:1<4900$$tNature Communications$$v10$$x2041-1723$$y2019
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