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@ARTICLE{Harrison:141600,
      author       = {Harrison, Theresa M and Maaß, Anne and Adams, Jenna N and
                      Du, Richard and Baker, Suzanne L and Jagust, William J},
      title        = {{T}au deposition is associated with functional isolation of
                      the hippocampus in aging.},
      journal      = {Nature Communications},
      volume       = {10},
      number       = {1},
      issn         = {2041-1723},
      address      = {[London]},
      publisher    = {Nature Publishing Group UK},
      reportid     = {DZNE-2020-07924},
      pages        = {4900},
      year         = {2019},
      abstract     = {The tau protein aggregates in aging and Alzheimer disease
                      and may lead to memory loss through disruption of medial
                      temporal lobe (MTL)-dependent memory systems. Here, we
                      investigated tau-mediated mechanisms of hippocampal
                      dysfunction that underlie the expression of episodic memory
                      decline using fMRI measures of hippocampal local coherence
                      (regional homogeneity; ReHo), distant functional
                      connectivity and tau-PET. We show that age and tau pathology
                      are related to higher hippocampal ReHo. Functional
                      disconnection between the hippocampus and other components
                      of the MTL memory system, particularly an anterior-temporal
                      network specialized for object memory, is also associated
                      with higher hippocampal ReHo and greater tau burden in
                      anterior-temporal regions. These associations are not
                      observed in the posteromedial network, specialized for
                      context/spatial information. Higher hippocampal ReHo
                      predicts worse memory performance. These findings suggest
                      that tau pathology plays a role in disconnecting the
                      hippocampus from specific MTL memory systems leading to
                      increased local coherence and memory decline.},
      keywords     = {Adult / Aged / Aged, 80 and over / Aging: metabolism /
                      Aging: physiology / Aging: psychology / Alzheimer Disease:
                      diagnostic imaging / Alzheimer Disease: metabolism /
                      Alzheimer Disease: physiopathology / Alzheimer Disease:
                      psychology / Amyloid beta-Peptides: metabolism / Aniline
                      Compounds / Brain: diagnostic imaging / Brain: metabolism /
                      Brain: physiopathology / Carbolines / Cognitive Aging:
                      physiology / Cognitive Aging: psychology / Contrast Media /
                      Entorhinal Cortex: diagnostic imaging / Entorhinal Cortex:
                      metabolism / Entorhinal Cortex: physiopathology / Executive
                      Function / Female / Functional Neuroimaging / Hippocampus:
                      diagnostic imaging / Hippocampus: metabolism / Hippocampus:
                      physiopathology / Humans / Male / Memory, Episodic / Memory,
                      Short-Term / Middle Aged / Neural Pathways: diagnostic
                      imaging / Neural Pathways: metabolism / Neural Pathways:
                      physiopathology / Neurofibrillary Tangles: metabolism /
                      Positron-Emission Tomography / Temporal Lobe: diagnostic
                      imaging / Temporal Lobe: metabolism / Temporal Lobe:
                      physiology / Thiazoles / Young Adult / tau Proteins:
                      metabolism /
                      2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole (NLM
                      Chemicals) / Amyloid beta-Peptides (NLM Chemicals) / Aniline
                      Compounds (NLM Chemicals) / Carbolines (NLM Chemicals) /
                      Contrast Media (NLM Chemicals) / MAPT protein, human (NLM
                      Chemicals) / Thiazoles (NLM Chemicals) / tau Proteins (NLM
                      Chemicals) / 7-(6-fluoropyridin-3-yl)-5H-pyrido(4,3-b)indole
                      (NLM Chemicals)},
      cin          = {AG Düzel},
      ddc          = {500},
      cid          = {I:(DE-2719)5000006},
      pnm          = {344 - Clinical and Health Care Research (POF3-344)},
      pid          = {G:(DE-HGF)POF3-344},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31653847},
      pmc          = {pmc:PMC6814780},
      doi          = {10.1038/s41467-019-12921-z},
      url          = {https://pub.dzne.de/record/141600},
}