Home > Publications Database > Tau deposition is associated with functional isolation of the hippocampus in aging. > print

001     141600
005     20240426115938.0
024 7 _ |a 10.1038/s41467-019-12921-z
|2 doi
024 7 _ |a pmid:31653847
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024 7 _ |a pmc:PMC6814780
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037 _ _ |a DZNE-2020-07924
041 _ _ |a English
082 _ _ |a 500
100 1 _ |a Harrison, Theresa M
|0 P:(DE-HGF)0
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|e Corresponding author
245 _ _ |a Tau deposition is associated with functional isolation of the hippocampus in aging.
260 _ _ |a [London]
|c 2019
|b Nature Publishing Group UK
264 _ 1 |3 online
|2 Crossref
|b Springer Science and Business Media LLC
|c 2019-10-25
264 _ 1 |3 print
|2 Crossref
|b Springer Science and Business Media LLC
|c 2019-12-01
336 7 _ |a article
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336 7 _ |a Output Types/Journal article
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336 7 _ |a Journal Article
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336 7 _ |a ARTICLE
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336 7 _ |a JOURNAL_ARTICLE
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336 7 _ |a Journal Article
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520 _ _ |a The tau protein aggregates in aging and Alzheimer disease and may lead to memory loss through disruption of medial temporal lobe (MTL)-dependent memory systems. Here, we investigated tau-mediated mechanisms of hippocampal dysfunction that underlie the expression of episodic memory decline using fMRI measures of hippocampal local coherence (regional homogeneity; ReHo), distant functional connectivity and tau-PET. We show that age and tau pathology are related to higher hippocampal ReHo. Functional disconnection between the hippocampus and other components of the MTL memory system, particularly an anterior-temporal network specialized for object memory, is also associated with higher hippocampal ReHo and greater tau burden in anterior-temporal regions. These associations are not observed in the posteromedial network, specialized for context/spatial information. Higher hippocampal ReHo predicts worse memory performance. These findings suggest that tau pathology plays a role in disconnecting the hippocampus from specific MTL memory systems leading to increased local coherence and memory decline.
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542 _ _ |i 2019-10-25
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|u https://creativecommons.org/licenses/by/4.0
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650 _ 7 |a 2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole
|2 NLM Chemicals
650 _ 7 |a Amyloid beta-Peptides
|2 NLM Chemicals
650 _ 7 |a Aniline Compounds
|2 NLM Chemicals
650 _ 7 |a Carbolines
|2 NLM Chemicals
650 _ 7 |a Contrast Media
|2 NLM Chemicals
650 _ 7 |a MAPT protein, human
|2 NLM Chemicals
650 _ 7 |a Thiazoles
|2 NLM Chemicals
650 _ 7 |a tau Proteins
|2 NLM Chemicals
650 _ 7 |a 7-(6-fluoropyridin-3-yl)-5H-pyrido(4,3-b)indole
|0 J09QS3Z3WB
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650 _ 2 |a Adult
|2 MeSH
650 _ 2 |a Aged
|2 MeSH
650 _ 2 |a Aged, 80 and over
|2 MeSH
650 _ 2 |a Aging: metabolism
|2 MeSH
650 _ 2 |a Aging: physiology
|2 MeSH
650 _ 2 |a Aging: psychology
|2 MeSH
650 _ 2 |a Alzheimer Disease: diagnostic imaging
|2 MeSH
650 _ 2 |a Alzheimer Disease: metabolism
|2 MeSH
650 _ 2 |a Alzheimer Disease: physiopathology
|2 MeSH
650 _ 2 |a Alzheimer Disease: psychology
|2 MeSH
650 _ 2 |a Amyloid beta-Peptides: metabolism
|2 MeSH
650 _ 2 |a Aniline Compounds
|2 MeSH
650 _ 2 |a Brain: diagnostic imaging
|2 MeSH
650 _ 2 |a Brain: metabolism
|2 MeSH
650 _ 2 |a Brain: physiopathology
|2 MeSH
650 _ 2 |a Carbolines
|2 MeSH
650 _ 2 |a Cognitive Aging: physiology
|2 MeSH
650 _ 2 |a Cognitive Aging: psychology
|2 MeSH
650 _ 2 |a Contrast Media
|2 MeSH
650 _ 2 |a Entorhinal Cortex: diagnostic imaging
|2 MeSH
650 _ 2 |a Entorhinal Cortex: metabolism
|2 MeSH
650 _ 2 |a Entorhinal Cortex: physiopathology
|2 MeSH
650 _ 2 |a Executive Function
|2 MeSH
650 _ 2 |a Female
|2 MeSH
650 _ 2 |a Functional Neuroimaging
|2 MeSH
650 _ 2 |a Hippocampus: diagnostic imaging
|2 MeSH
650 _ 2 |a Hippocampus: metabolism
|2 MeSH
650 _ 2 |a Hippocampus: physiopathology
|2 MeSH
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Male
|2 MeSH
650 _ 2 |a Memory, Episodic
|2 MeSH
650 _ 2 |a Memory, Short-Term
|2 MeSH
650 _ 2 |a Middle Aged
|2 MeSH
650 _ 2 |a Neural Pathways: diagnostic imaging
|2 MeSH
650 _ 2 |a Neural Pathways: metabolism
|2 MeSH
650 _ 2 |a Neural Pathways: physiopathology
|2 MeSH
650 _ 2 |a Neurofibrillary Tangles: metabolism
|2 MeSH
650 _ 2 |a Positron-Emission Tomography
|2 MeSH
650 _ 2 |a Temporal Lobe: diagnostic imaging
|2 MeSH
650 _ 2 |a Temporal Lobe: metabolism
|2 MeSH
650 _ 2 |a Temporal Lobe: physiology
|2 MeSH
650 _ 2 |a Thiazoles
|2 MeSH
650 _ 2 |a Young Adult
|2 MeSH
650 _ 2 |a tau Proteins: metabolism
|2 MeSH
700 1 _ |a Maaß, Anne
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700 1 _ |a Adams, Jenna N
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700 1 _ |a Du, Richard
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700 1 _ |a Baker, Suzanne L
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700 1 _ |a Jagust, William J
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773 1 8 |a 10.1038/s41467-019-12921-z
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|v 10
|y 2019
|x 2041-1723
773 _ _ |a 10.1038/s41467-019-12921-z
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